Potent Immunosuppressive Activities of Cytomegalovirus- Encoded Interleukin-10

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Analysis of the Protein-Coding Content of the Sequence of Human Cytomegalovirus Strain AD169

1990 • 1,280 citations

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

1993 • 771 citations

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

1997 • 691 citations

Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease

1991 • 686 citations

Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40

2000 • 641 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

Properties and Functions of Interleukin-10

1994 • 516 citations

Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)

2000 • 504 citations

Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens

1988 • 470 citations

IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes

1999 • 409 citations

The Interleukin-10 Signal Transduction Pathway and Regulation of Gene Expression in Mononuclear Phagocytes

1999 • 403 citations

Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.

1996 • 379 citations

Cytomegalovirus encodes a potent α chemokine

1999 • 339 citations

Human Cytomegalovirus Inhibits Major Histocompatibility Complex Class II Expression By Disruption of the Jak/Stat Pathway

1998 • 337 citations

The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association

1995 • 320 citations

Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules

1997 • 239 citations

Immune evasion by cytomegalovirus—survival strategies of a highly adapted opportunist

1998 • 214 citations

A homolog of interleukin-10 is encoded by the poxvirus orf virus

1997 • 210 citations

Downregulation of TAP1 in B Lymphocytes by Cellular and Epstein-Barr Virus–Encoded Interleukin-10

1997 • 186 citations

The T-cell-independent role of gamma interferon and tumor necrosis factor alpha in macrophage activation during murine cytomegalovirus and herpes simplex virus infections

1995 • 172 citations

Primate Cytomegaloviruses Encode and Express an IL-10-like Protein

2000 • 162 citations

Murine Cytomegalovirus Infection Down-Regulates MHC Class II Expression on Macrophages by Induction of IL-10

1999 • 160 citations

Viruses Perturb Lymphocyte Functions: Selected Principles Characterizing Virus-Induced Immunosuppression

1987 • 152 citations

Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers

1992 • 124 citations

Interleukin-10 gene knock-out mice: a model of chronic inflammation

1995 • 118 citations

T cell therapy of human CMV and EBV infection in immunocompromised hosts

1997 • 102 citations

The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-like gene

1993 • 93 citations

Identification of functional domains on human interleukin 10

1997 • 75 citations

Interleukin‐10‐induced CD8 cell proliferation

1999 • 72 citations

The Role of the Tumor Necrosis Factor System and Interleukin‐10 during Cytomegalovirus Infection in Renal Transplant Recipients

2000 • 72 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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