Characterization and regulation of insulin binding by embryonic chick heart cells

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

An Improved Diphenylamine Method for the Estimation of Deoxyribonucleic Acid

1965 • 1,968 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction

1978 • 784 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Hormonal regulation of peptide receptors and target cell responses

1979 • 531 citations

Membrane Receptors and Hormone Action

1976 • 484 citations

Regulation of spontaneous activity and growth of embryonic chick heart cells in tissue culture

1967 • 280 citations

Isolation and Characterization of Chicken Insulin

1968 • 278 citations

Insulin Receptors in Human Circulating Cells and Fibroblasts

1972 • 228 citations

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

1978 • 220 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Receptors for Insulin, NSILA-s, and Growth Hormone: Applications to Disease States in Man

1975 • 174 citations

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: Evidence for generation of insulin's second messenger in a subcellular system

1980 • 172 citations

BINDING OF HORMONE TO TISSUE: THE FIRST STEP IN POLYPEPTIDE HORMONE ACTION

1966 • 168 citations

Characterization of the binding of multiplication-stimulating activity to a receptor for growth polypeptides in chick embryo fibroblasts.

1977 • 153 citations

Binding of insulin to isolated nuclei.

1976 • 146 citations

Uptake of insulin by plasmalemma and Golgi subcellular fractions of rat liver.

1980 • 116 citations

Membrane Receptors for Polypeptide Hormones

1975 • 114 citations

The potassium-sensitivity of isolated embryonic heart cells increases with development

1970 • 107 citations

On the development of amino acid transport systems.

1973 • 100 citations

Decreased Binding of Insulin to Its Receptor in Patients with Congenital Generalized Lipodystrophy

1977 • 93 citations

Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes.

1978 • 93 citations

Stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels.

1979 • 93 citations

Differentiation of 3T3-L1 fibroblasts to adipocytes. Effect of insulin and indomethacin on the levels of insulin receptors

1978 • 92 citations

Insulin-dependent regulation of the insulin-sensitivity of adipocytes

1978 • 86 citations

Amino acid transport by aggregates of cultured chicken heart cells. Effect of insulin.

1975 • 64 citations

Insulin Binding to Adipocytes: Evidence for Functionally Distinct Receptors

1978 • 63 citations

The Insulin Receptor: Properties and Regulation

1977 • 54 citations

Amino acid uptake in isolated chick embryo heart cells. Effect of insulin

1969 • 46 citations

Insulin-induced reduction of membrane receptor concentrations in isolated fat cells and lymphocytes. Independence from receptor occupation and possible relation to proteolytic activity of insulin.

1975 • 45 citations

Proinsulin Binds to a Growth Peptide Receptor and Stimulates DNA Synthesis in Chick Embryo Fibroblasts¹

1977 • 44 citations

Development of an insulin-sensitive glucose transport system in chick embryo hearts

1961 • 44 citations

Measurement of DNA in isolated granulocytes by the ethidium technique

1973 • 36 citations

Evidence Supporting a Two-Receptor Model for Insulin Binding by Cultured Embryonic Heart Cells*

1980 • 33 citations

Ouabain-resistant hyperpolarization induced by insulin in aggregates of embryonic heart cells.

1980 • 31 citations

Insulin-induced insulin resistance of alpha-aminoisobutyric acid transport in cultured human skin fibroblasts.

1979 • 28 citations

Mechanisms of the Fasting-Induced Increase in Insulin Binding to Rat Adipocytes

1978 • 28 citations

Relationship of Insulin Binding to Amino Acid Transport by Cultured 14-Day Embryonic Chick Heart Cells*

1979 • 28 citations

Insulin receptors in human circulating cells and fibroblasts

1972 • 24 citations

Further Evidence for Functional Heterogeneity of Adipocyte Insulin Receptors*

1979 • 22 citations

Glucose uptake by chicken embryo hearts at various stages of development

1977 • 21 citations

Developmental control of 2-aminoisobutyric acid transport by 7- and 14-day chick heart cell aggregates

1978 • 14 citations