Insulin-induced reduction of membrane receptor concentrations in isolated fat cells and lymphocytes. Independence from receptor occupation and possible relation to proteolytic activity of insulin.

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

Protein Purification by Affinity Chromatography

1970 • 2,809 citations

A simplified method for cyanogen bromide activation of agarose for affinity chromatography

1974 • 1,951 citations

Microfilaments in Cellular and Developmental Processes

1971 • 1,563 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Colchicine-binding protein of mammalian brain and its relation to microtubules

1968 • 1,140 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Membrane Receptors

1974 • 636 citations

Proteolytic Enzymes Initiating Cell Division and Escape from Contact Inhibition of Growth

1970 • 513 citations

The Relationship between the Insulin-binding Capacity of Fat Cells and the Cellular Response to Insulin

1971 • 464 citations

Insulin-Receptor Interactions in Adipose Tissue Cells: Direct Measurement and Properties

1971 • 443 citations

“Pleiotypic Response”

1971 • 415 citations

INTERACTION OF INSULIN WITH THE CELL MEMBRANE: THE PRIMARY ACTION OF INSULIN

1969 • 381 citations

Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake.

1975 • 367 citations

A procedure for measurement of distribution spaces in isolated fat cells

1972 • 366 citations

Studies on the Metabolism of Adipose Tissue. XII. The Effects of Insulin and Epinephrine on Free Fatty Acid and Glycerol Production in the Presence and Absence of Glucose^*

1963 • 356 citations

Release from Density Dependent Growth Inhibition by Proteolytic Enzymes

1970 • 338 citations

Epidermal Growth Factor: Receptors in Human Fibroblasts and Modulation of Action by Cholera Toxin

1973 • 328 citations

Peptide hormone binding to receptors: A review of direct studies in vitro

1973 • 286 citations

Density and cell cycle dependence of cell surface proteins in hamster fibroblasts

1974 • 262 citations

Epidermal growth factor

1974 • 236 citations

Interaction of wheat germ agglutinin and concanavalin A with isolated fat cells

1973 • 235 citations

Insulin Receptors in Human Circulating Cells and Fibroblasts

1972 • 228 citations

The partial purification from calf serum of a fraction with multiplication‐stimulating activity for chicken fibroblasts in cell culture and with non‐suppressible insulin‐like activity

1972 • 209 citations

Role of surface alterations in cell transformation: the importance of proteases and surface proteins

1974 • 192 citations

Unmasking of Insulin Receptors in Fat Cells and Fat Cell Membranes

1971 • 184 citations

Control of the Initiation of DNA Synthesis in 3T3 Cells: Serum Factors

1974 • 184 citations

Perturbation of the Insulin Receptor of Isolated Fat Cells with Proteolytic Enzymes

1971 • 171 citations

Destruction and Restoration of the Insulin Effector System of Isolated Fat Cells

1969 • 161 citations

Emergence of Insulin Receptors on Human Lymphocytes During In Vitro Transformation

1972 • 153 citations

Effects of Insulin on the Levels of Adenosine 3′:5′-Monophosphate and Lipolysis in Isolated Rat Epididymal Fat Cells

1973 • 144 citations

Insulin-like Effects of Trypsin on Fat Cells

1971 • 138 citations

Adenosine Triphosphate-dependent Inhibition of Insulin-stimulated Glucose Transport in Fat Cells

1974 • 135 citations

Membrane receptors as general markers for plasma membrane isolation procedures. The use of 125-I-labeled wheat germ agglutinin, insulin, and cholera toxin

1975 • 124 citations

Inhibitors of glucagon inactivationEffect on glucagon-receptor interactions and glucagon-stimulated adenylate cyclase activity in liver cell membranes

1974 • 118 citations

Removal and Metabolism of Triglycerides by Perfused Liver

1964 • 109 citations

Thymic Lymphocytes in Obese (ob/ob) Mice

1974 • 104 citations

Destruction of Insulin Effector System of Adipose Tissue Cells by Proteolytic Enzymes

1969 • 102 citations

Stimulation of density‐inhibited cell cultures by insulin

1973 • 90 citations

Insulin stimulates myogenesis in a rat myoblast line

1974 • 86 citations

Anabolic Responses of Diaphragm Muscle to Insulin and to Other Pancreatic Proteins.

1964 • 80 citations

Antilipolytic Action of Insulin on Fat Cells

1972 • 79 citations

Direct measurements of sugar uptake in small and large adipocytes from young and adult rats

1974 • 78 citations

Response of Trypsin-treated Brown and White Fat Cells to Hormones

1969 • 73 citations

Glucose Transport in Fat Cell Membranes

1971 • 73 citations

The Involvement of Cyclic AMP in the Hormonal Regulation of Protein Synthesis in Rat Adipocytes1

1972 • 64 citations

Trypsin treatment of adipocytes: Effect on sensitivity to insulin

1972 • 62 citations

Regulation of Cell Membrane Permeability in Skeletal Muscle

1969 • 61 citations

Effect of Insulin on Sterol and Fatty Acid Synthesis and Hydroxymethylglutaryl CoA Reductase Activity in Mammalian Cells Grown in Culture

1974 • 60 citations

Insulin-like Effect of Clostridial Phospholipase C, Neuraminidase, and Other Bacterial Factors on Brown Fat Cells

1971 • 54 citations

The effect of proteolytic enzymes on isolated adipose cells

1966 • 52 citations

Comparisons of the Effects of Bacillus subtilis Protease, Type VIII (Subtilopeptidase A), and Insulin on Isolated Adipose Cells

1967 • 46 citations

Changes in the binding of concanavalin A and wheat germ agglutinin to human lymphocytes during in vitro transformation

1973 • 39 citations

STIMULATION BY INSULIN OF RNA SYNTHESIS IN CHICK FIBROBLASTS

1974 • 31 citations

Antilipolytic activity of insulin and proinsulin on ACTH and cyclic nucleotide-induced lipolysis in the isolated adipose cell of rat

1970 • 29 citations

The Effects of Insulin on Lipolysis Evoked by Cyclic AMP and Its Dibutyryl Analog

1969 • 23 citations

Insulin-catalyzed proteolysis

1964 • 22 citations

Lipolytic Effects of High Concentrations of Insulin on Isolated Fat Cells: Enhancement of the Response to Lipolytic Hormones

1973 • 21 citations

Effects of Insulin and Proinsulin on Isolated Fat Cells and Hemidiaphragms from Rats1¹

1970 • 19 citations