The Consequences of the Intracellular Retention of Pathogen-Derived T-Cell-Independent Antigens on Protein Presentation to T Cells

Biological roles of oligosaccharides: all of the theories are correct

1993 • 5,121 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

T Cell-Independent Antigens Type 2

1995 • 798 citations

CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens

1995 • 751 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling

1980 • 574 citations

Immunological modulation and evasion by helminth parasites in human populations

1993 • 534 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Characterization and Classification of Dextrans from Ninety-six Strains of Bacteria^1b

1954 • 450 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM LEUKOCYTES EXPOSED TO IMMUNE COMPLEXES AND OTHER PARTICLES

1971 • 439 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Biology of Carbohydrates

1981 • 426 citations

The endocytic activity of dendritic cells.

1995 • 308 citations

Targeting of membrane proteins to endosomes and lysosomes

1994 • 304 citations

Thymus-Independent B-Cell Induction and Paralysis

1975 • 304 citations

Prevention of phagosome-lysosome fusion in cultured macrophages by sulfatides of Mycobacterium tuberculosis.

1976 • 301 citations

The chemical structure of the cord factor of Mycobacterium tuberculosis

1956 • 294 citations

6. Polysaccharides of baker's yeast. Part IV. Mannan

1961 • 274 citations

Structural Features of Polysaccharides That Induce Intra-Abdominal Abscesses

1993 • 266 citations

Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity

1994 • 256 citations

Biogenesis of phagolysosomes: the 'kiss and run' hypothesis

1995 • 252 citations

Mechanism of C. trachomatis attachment to eukaryotic host cells

1992 • 244 citations

Different macrophage populations distinguished by means of fluorescent polysaccharides. Recognition and properties of marginal‐zone macrophages

1981 • 238 citations

NONOPSONIC PHAGOCYTOSIS OF MICROORGANISMS

1995 • 235 citations

MICROBIOLOGY OF LUNG INFECTIONS IN CYSTIC FIBROSIS PATIENTS

1982 • 234 citations

Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid

1984 • 228 citations

Thymus-independent antigens: complexity of B-lymphocyte activation revealed

1982 • 227 citations

CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family.

1996 • 212 citations

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

1994 • 212 citations

Subversion of the immune system by pathogens

1994 • 206 citations

Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes.

1994 • 184 citations

Haworth Memorial Lecture. Human blood groups and carbohydrate chemistry

1978 • 183 citations

Interaction between Protein-Derived Immunogenic Peptides and Ia

1986 • 180 citations

THE DEFECT IN HURLER AND HUNTER SYNDROMES, II. DEFICIENCY OF SPECIFIC FACTORS INVOLVED IN MUCOPOLYSACCHARIDE DEGRADATION

1969 • 174 citations

Surface Immunoglobulin D as a Functional Receptor for a Subclass of B Lymphocytes

1977 • 173 citations

MHC interaction and T cell recognition of carbohydrates and glycopeptides.

1992 • 171 citations

Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action

1991 • 159 citations

Pathophysiology of hemolysis in glucose-6-phosphate dehydrogenase deficiency.

1990 • 157 citations

Phagocytosed Live Listeria monocytogenes Influences Rab5-regulated in Vitro Phagosome-Endosome Fusion

1996 • 149 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

The inhibitory effects of mycobacterial lipoarabinomannan and polysaccharides upon polyclonal and monoclonal human T cell proliferation.

1988 • 145 citations

Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules.

1991 • 144 citations

Antigenic Competition: Cellular or Humoral

1967 • 135 citations

T‐Cell Recognition of Lysozyme: The Biochemical Basis of Presentation

1987 • 133 citations

Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation.

1983 • 132 citations

Molecular size-fractionation during endocytosis in macrophages.

1995 • 130 citations

Membrane trafficking along the phagocytic pathway

1995 • 130 citations

Cord factor (alpha,alpha-trehalose 6,6'-dimycolate) inhibits fusion between phospholipid vesicles.

1991 • 127 citations

Leishmania major interferes with antigen presentation by infected macrophages.

1993 • 124 citations

Chemically related antigens compete for presentation by accessory cells to T cells.

1982 • 121 citations

Macrophage-Pathogen Interactions

1993 • 121 citations

A Mannose-containing Trisaccharide Isolated from Urines of Three Patients with Mannosidosis

1973 • 114 citations

Follicular dendritic cells in suspension: identification, enrichment, and initial characterization indicating immune complex trapping and lack of adherence and phagocytic activity.

1985 • 110 citations

Inhibition of phagosome-lysosome fusion in macrophages by certain mycobacteria can be explained by inhibition of lysosomal movements observed after phagocytosis.

1987 • 109 citations

Marginal zone macrophages and their role in the immune response against T‐independent type 2 antigens: modulation of the cells with specific antibody

1989 • 108 citations

A randomized comparison of three bivalent Streptococcus pneumoniae glycoprotein conjugate vaccines in young children

1994 • 104 citations

Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes.

1993 • 102 citations

Comparative immunogenicities of Vi polysaccharide-protein conjugates composed of cholera toxin or its B subunit as a carrier bound to high- or lower-molecular-weight Vi

1989 • 101 citations

Processing and Presentation of Endocytically Acquired Protein Antigens by MHC Class II and Class I Molecules

1996 • 99 citations

Glycopeptides bind MHC molecules and elicit specific T cell responses.

1993 • 98 citations

Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth.

1992 • 89 citations

Surface structures of microorganisms and their interactions with the mammalian host

1990 • 84 citations

Bacterial cell wall-induced hepatic granulomas. An in vivo model of T cell-dependent fibrosis.

1986 • 82 citations

Immunochemical studies on dextrans. V. Specificity and cross-reactivity with dextrans of the antibodies formed in rabbits to isomaltonic and isomaltotrionic acids coupled to bovine serum albumin.

1966 • 80 citations

Tolerogenic or immunogenic activity of hapten‐conjugated polysaccharides correlated with cellular localization

1981 • 79 citations

Antigen‐presenting cell function of dendritic cells and macrophages in proliferative T cell responses to soluble and particulate antigens

1986 • 78 citations

Rheumatic-like Cardiac Lesions in Mice

1966 • 76 citations

Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice

1974 • 74 citations

Cellular control of abscess formation: role of T cells in the regulation of abscesses formed in response to Bacteroides fragilis.

1986 • 73 citations

The binding of fucose-containing glycoproteins by hepatic lectins. Purification of a fucose-binding lectin from rat liver.

1986 • 73 citations

Intralysosomal accumulation of polyanions. I. Fusion of pinocytic and phagocytic vacuoles with secondary lysosomes.

1982 • 72 citations

Macrophage activation in murine African trypanosomiasis

1983 • 71 citations

Macrophages as primary target cells and mediators of immune dysfunction in African trypanosomiasis

1981 • 70 citations

Mechanisms of Antigen Processing

1988 • 66 citations

Human adult immunogenicity of protein-coupled pneumococcal capsular antigens of serotypes prevalent in otitis media

1989 • 62 citations

Immunochemical Studies on Dextrans

1966 • 62 citations

Macrophage-pathogen interactions

1995 • 61 citations

A comparative study of the immunogenicity of pneumococcal type 4 polysaccharide and oligosaccharide tetanus toxoid conjugates in adult mice.

1991 • 61 citations

COMPETITION OF HASTENS

1966 • 60 citations

The (alpha2-->8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages

1996 • 58 citations

Specificity of glycopeptide-specific T cells.

1995 • 56 citations

ANTIGENIC COMPETITION BETWEEN POLYPEPTIDYL DETERMINANTS IN NORMAL AND TOLERANT RABBITS

1968 • 56 citations

Intracellular interference with antigen presentation.

1988 • 54 citations

Antigen Competition: A Paradox

1970 • 53 citations

Structure of the gene for a carbohydrate-binding receptor unique to rat kupffer cells

1991 • 52 citations

Attachment of oligosaccharides to peptide antigen profoundly affects binding to major histocompatibility complex class II molecules and peptide immunogenicity

1994 • 52 citations

Synthetic antigens composed exclusively of L- or D- amino acids. II. Effect of optical configuration on the metabolism and fate of synthetic polypeptide antigens in mice.

1968 • 51 citations

Polysaccharides of micro-organisms

1960 • 50 citations

Acute infection of mice with lactic dehydrogenase virus (LDV) impairs the antigen-presenting capacity of their macrophages

1982 • 49 citations

T cell recognition of bovine ribonuclease. Self/non-self discrimination at the level of binding to the I-Ak molecule.

1988 • 47 citations

Competition of Antigens

1964 • 47 citations

Antibody Formation After Injection of Heterologous Immune Globulin

1957 • 45 citations

Immunogenic Properties of α(1 → 6) Dextran, Its Protein Conjugates, and Conjugates of Its Breakdown Products in Mice

1984 • 44 citations

THE EFFECT OF ANTIGENIC COMPETITION ON VARIOUS MANIFESTATIONS OF HUMORAL ANTIBODY FORMATION AND CELLULAR IMMUNITY

1968 • 44 citations

Uveitis and arthritis induced by systemic injection of streptococcal cell walls.

1986 • 43 citations

Modulation of Immune Responses by Surface Polysaccharides of Candida albicans

1988 • 43 citations

Processing and presentation of intact hen egg‐white lysozyme by dendritic cells

1992 • 42 citations

The carbohydrates of glycoproteins

1994 • 39 citations

Wortmannin, an inhibitor of phospholipase D activation, selectively blocks major histocompatibility complex class II‐restricted antigen presentation

1994 • 36 citations

Chronic Self-Perpetuating Arthritis Induced in Rabbits by a Cell-Free Extract of Group A Streptococci

1973 • 29 citations

Antibody formation after injection of heterologous immune globulin. II. Competition of antigens.

1957 • 28 citations

Galactose receptors and presentation of HIV envelope glycoprotein to specific human T cells.

1992 • 28 citations

Experimentelle Vakuolenbildung in Fibrozyten der Gewebekultur und deren F�rbung durch Neutralrot

1936 • 28 citations

Weitere Untersuchungen über Eiweißpräzipitine

1904 • 27 citations

Phagolysosomal escape by intracellular pathogens

1991 • 26 citations

Lack of effect of Candida albicans mannan on development of protective immune responses in experimental murine candidiasis

1994 • 26 citations

Depression by Pseudomonas aeruginosa of Two T-Cell-Mediated Responses, Anti- Listeria Immunity and Delayed- Type Hypersensitivity to Sheep Erythrocytes

1982 • 25 citations

Untersuchungen über Eiweisspräzipitine

1902 • 24 citations

Lysosomes and Vacuolation of the Liver Cell

1963 • 23 citations

A mechanism for inhibition of luminol-dependent neutrophil chemiluminescence by polyanions.

1983 • 22 citations

Immunochemical studies on dextrans. 8. Specificity and cross-reactivity with dextrans of the antibodies formed in rabbits to isomaltohexaonic acid coupled to bovine serum albumin.

1974 • 21 citations

Phenotypic characterization and functional activity of human milk macrophages

1984 • 21 citations

IFN-gamma-induced MHC class II gene expression is suppressed in endothelial cells by dextran sulfate.

1996 • 19 citations

Inhibitory Effects of Thymus-Independent Type 2 Antigens on MHC Class II-Restricted Antigen Presentation: Comparative Analysis of Carbohydrate Structures and the Antigen Presenting Cell

1997 • 19 citations

Analysis of thymus‐independent type 2 antigen uptake by marginal zone macrophages in thin slices of viable lymphoid tissue in vitro

1990 • 19 citations

Surface structures of microorganisms and their interactions with the mammalian host

1990 • 17 citations

Precipitin production in chickens. XIII. A quantitative study of the effect of simultaneous injection of two antigens.

1956 • 16 citations

Abrogation of suppression of delayed hypersensitivity induced by Candida albicans-derived mannan by treatment with monophosphoryl lipid A

1993 • 16 citations

Phosphatidylinositol 3-kinase inhibitors and their effects on cell signaling pathways

1995 • 15 citations

Reciprocal Competition of a Variety of Antigens in the Suppression of Immunologic Reactivity

1964 • 15 citations

Iron Salts and Iron-Containing Porphyrins Block Presentation of Protein Antigens by Macrophages to MHC Class II-Restricted T Cells

1996 • 14 citations

Localized gut-associated lymphoid tissue hemorrhage induced by intravenous peptidoglycan-polysaccharide polymers

1986 • 13 citations

On the Rôle of the Reticulo Endothelial System in the Tuberculin Hypersensitiveness

1926 • 12 citations

Immunochemical Studies on Dextrans

1974 • 11 citations

The prevention of autoimmunity to the thyroid and allergic thyroiditis bantigenic competition.

1970 • 11 citations

The Prevention of Autoimmunity to the Thyroid and Allergic Thyroiditis by Antigenic Competition

1970 • 10 citations

Precipitin Production in Chickens

1956 • 10 citations

Intracellular Immunoglobulins in Human Milk Macrophages

1986 • 10 citations

Suppression of the delayed-type hypersensitivity and cell-mediated immune responses to Listeria monocytogenes induced by Pseudomonas aeruginosa

1987 • 10 citations

The mode of interaction with macrophages of two ordered synthetic polypeptides which differ in their thymus dependency.

1978 • 8 citations

Participation of intracellular oxidative pathways in antigen processing by dendritic cells, B cells and macrophages

1994 • 8 citations

Chapter VII

1963 • 7 citations

Antigenic Competition between Mouse Thyroglobulin and Bovine Serum Albumin Demonstrated by Adoptive Transfer

1971 • 5 citations

Chapter VII

1963 • 2 citations

Modulation of the Immune System by Neisseria meningitidis

1987 • 2 citations

The Oligosaccharides* *Prepared with support from the National Institute of Arthritis and Metabolic Diseases (USPHS A-3555) and the U.S. Army, Medical Research and Development: Board (ASG MD-773).

1963 • 1 citations