A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

1998 • 852 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module

1999 • 645 citations

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

2000 • 641 citations

Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

1999 • 537 citations

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 • 503 citations

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation

2001 • 459 citations

Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital

2002 • 455 citations

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

2000 • 384 citations

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

2001 • 355 citations

Induction of CYP2C genes in human hepatocytes in primary culture.

2001 • 316 citations

Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles.

1999 • 306 citations

Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450.

1999 • 272 citations

Transcriptional Regulation of CYP2C9 Gene

2002 • 260 citations

Dexamethasone Enhances Constitutive Androstane Receptor Expression in Human Hepatocytes: Consequences on Cytochrome P450 Gene Regulation

2000 • 246 citations

Human CYP2B6: expression, inducibility and catalytic activities.

1999 • 245 citations

Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.

1997 • 245 citations

Transcriptional Regulation of the HumanCYP3A4Gene by the Constitutive Androstane Receptor

2002 • 244 citations

Orphan Nuclear Receptors: The Exotics of Xenobiotics

2001 • 216 citations

Human CYP2B6

1999 • 203 citations

Cytochrome P-450 2B6 Is Responsible for Interindividual Variability of Propofol Hydroxylation by Human Liver Microsomes

2001 • 202 citations

Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

2001 • 184 citations

Further characterization of the expression in liver and catalytic activity of CYP2B6.

1998 • 173 citations

The use of adult human hepatocytes in primary culture and other in vitro systems to investigate drug metabolism in man

1996 • 157 citations

Regulation of HumanCYP2C9by the Constitutive Androstane Receptor: Discovery of a New Distal Binding Site

2002 • 156 citations

The Peptide Near the C Terminus Regulates Receptor CAR Nuclear Translocation Induced by Xenochemicals in Mouse Liver

2001 • 146 citations

Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction

1997 • 146 citations

Combination of Protease Inhibitors for the Treatment of HIV-1-Infected Patients: A Review of Pharmacokinetics and Clinical Experience

2002 • 129 citations

Expression of Human Cytochrome P450 2B6 in Escherichia coli: Characterization of Catalytic Activity and Expression Levels in Human Liver

2000 • 111 citations

Involvement of human liver cytochrome P4502B6in the metabolism of propofol

2001 • 96 citations

Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

2000 • 95 citations

CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes.

2001 • 88 citations

Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

1998 • 69 citations

Effect of Tamoxifen on the Enzymatic Activity of Human Cytochrome CYP2B6

2002 • 66 citations

Role of human CYP2B6 in S-mephobarbital N-demethylation.

1999 • 33 citations