Neuropathology of thiamine deficiency: an update on the comparative analysis of human disorders and experimental models

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Brain stem reticular formation and activation of the EEG

1949 • 4,188 citations

A rapid radiochemical method for the determination of choline acetyltransferase

1975 • 2,406 citations

The Neuropsychology of Memory

1984 • 2,129 citations

Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease

1983 • 811 citations

Neuropsychology of Memory

1992 • 625 citations

The origins of cholinergic and other subcortical afferents to the thalamus in the rat

1987 • 587 citations

Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

1987 • 532 citations

Brain Lesions in Alcoholics

1993 • 530 citations

Alcohol and the liver: 1994 update

1994 • 511 citations

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

1988 • 406 citations

The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders Due to Alcoholism and Malnutrition

1990 • 393 citations

Muscimol binding in rat brain: Association with synaptic GABA receptors

1978 • 377 citations

The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease.

1988 • 364 citations

Reduced Cerebral Grey Matter Observed in Alcoholics Using Magnetic Resonance Imaging

1991 • 355 citations

The Korsakoff Syndrome

1995 • 349 citations

Ascending projections from the pedunculopontine tegmental nucleus and the adjacent mesopontine tegmentum in the rat

1988 • 343 citations

The incidence of Wernicke's encephalopathy in Australia--a neuropathological study of 131 cases.

1983 • 343 citations

The genetic epidemiology of alcoholism

1990 • 305 citations

GABAA receptor channels: from subunits to functional entities

1992 • 255 citations

Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria‐fornix transection

1989 • 255 citations

Neuropathology of alcoholism

2014 • 237 citations

Location of Lesions in Korsakoff's Syndrome: Neuropsychological and Neuropathological Data on Two Patients

1988 • 185 citations

Reduced lumbar CSF somatostatin in levels in Alzheimer's disease

1982 • 184 citations

Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

1990 • 160 citations

Protective effects of the glutamate antagonist MK-801 on pyrithiamine- induced lesions and amino acid changes in rat brain

1990 • 154 citations

Brain stem reticular formation and activation of the EEG. Electroencephalogr., clin.

1949 • 153 citations

Model of Wernicke's Encephalopathy

1981 • 148 citations

Thiamine deficiency in rats produces cognitive and memory deficits on spatial tasks that correlate with tissue loss in diencephalon, cortex and white matter

1995 • 147 citations

The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats

1991 • 142 citations

Choline acetyltransferase immunoreactivity in the rat thalamus

1987 • 134 citations

Thiamin and the Brain

1988 • 116 citations

Extracellular Glutamate Is Increased in Thalamus During Thiamine Deficiency‐Induced Lesions and Is Blocked by MK‐801

1993 • 105 citations

Relationship Between the Wernicke and the Korsakoff Syndrome

1956 • 105 citations

Glial cell changes in the brain stem of thiamine-deficient rats.

1967 • 102 citations

Thiamine deficiency and wernicke's encephalopathy in AIDS

1991 • 97 citations

Ultrastructural features of early brain stem lesions of thiamine-deficient rats.

1968 • 96 citations

Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain

1986 • 90 citations

Learning disturbances following excitotoxic lesion of cholinergic pedunculo-pontine nucleus in the rat

1991 • 88 citations

Excitotoxic Cytopathology, Progression, and Reversibility of Thiamine Deficiency-induced Diencephalic Lesions

1995 • 88 citations

A Comparison of Methodologies for the Study of Functional Transmitter Neurochemistry in Human Brain

1988 • 83 citations

Impairment of behavior and acetylcholine metabolism in thiamine deficiency.

1981 • 82 citations

Activation of brain serotonin metabolism by heat: Role of midbrain raphe neurons

1971 • 81 citations

Glutamate and γ‐Aminobutyric Acid Neurotransmitter Systems in the Acute Phase of Maple Syrup Urine Disease and Citrullinemia Encephalopathies in Newborn Calves

1992 • 77 citations

Thiamine deficiency depletes cortical norepinephrine and impairs learning processes in the rat

1985 • 77 citations

Brainstem Serotonergic Neurons in Chronic Alcoholics With and Without the Memory Impairment of Korsakoffʼs Psychosis

1993 • 76 citations

NEUROANATOMICAL CONSEQUENCES OF THIAMINE DEFICIENCY: A COMPARATIVE ANALYSIS

1985 • 74 citations

Effective Pharmacotherapy of Alcoholic Amnestic Disorder With Fluvoxamine

1989 • 71 citations

Radioligand—receptor binding studies: what's wrong with the scatchard analysis?

1984 • 71 citations

Aetiology of alcoholic brain damage: alcoholic neurotoxicity or thiamine malnutrition?

1994 • 68 citations

Intermittent thiamine deficiency in the rhesus monkey. I. Progression of neurological signs and neuroanatomical lesions

1983 • 67 citations

Evidence for early blood-brain barrier breakdown in experimental thiamine deficiency in the mouse

1995 • 67 citations

Neurochemical pathology in Korsakoff's psychosis: Implications for other cognitive disorders

1984 • 66 citations

Decrease of benzodiazepine receptors in frontal cortex of alcoholics

1988 • 66 citations

Thiamine Deficiency in Hospitalized Elderly Patients

1994 • 62 citations

Nutrition and alcoholic encephalopathies

1987 • 60 citations

Analysis of aversively conditioned learning and memory in rats recovered from pyrithiamine-induced thiamine deficiency.

1991 • 60 citations

Possible involvement of thiamine in acetylcholine release

1976 • 58 citations

Diencephalic lesions, learning impairments, and intact retrograde memory following acute thiamine deficiency in the rat

1992 • 58 citations

Metabolism of Thiamine Triphosphate in Rat Brain: Correlation with Chloride Permeability

1993 • 58 citations

Effect of experimental thiamine deficiency on the nervous system of the rhesus monkey.

1949 • 56 citations

Fine structure of the early changes in the vestibular nuclei of the thiamine-deficient rat.

1968 • 56 citations

Basal forebrain efferents to the medial dorsal thalamic nucleus in the rhesus monkey

1988 • 56 citations

Impairment of olfactory, auditory, and spatial serial reversal learning in rats recovered from pyrithiamine-induced thiamine deficiency.

1991 • 54 citations

The Pathology of Chastek Paralysis in Foxes: A Counterpart of Wernicke's Hemorrhagic Pollioencephalitis of Man.

1942 • 54 citations

Uptake of pyrithiamine by tissue of rats

1961 • 51 citations

Fewer pigmented neurons in the locus coeruleus of uncomplicated alcoholics

1994 • 50 citations

Thiamine Status of Healthy and Institutionalized Elderly Subjects: Analysis of Dietary Intake and Biochemical Indices

1990 • 48 citations

Thiamin status of the elderly: dietary intake and thiamin pyrophosphate response.

1994 • 47 citations

Difference in susceptibility to teratogenic effects of alcohol in discordant twins exposed to alcohol during the second half of gestation

1994 • 46 citations

Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy

1995 • 45 citations

Implications of nutritional status on human biochemistry, physiology, and health

1984 • 44 citations

Memory related role of the posterior cholinergic system

1986 • 44 citations

The effect of thiamine deficiency on the structure and physiology of the rat forebrain

1988 • 44 citations

Analysis of aversively conditioned learning and memory in rats recovered from pyrithiamine-induced thiamine deficiency.

1991 • 43 citations

Increased Densities of Binding Sites for the “Peripheral-Type” Benzodiazepine Receptor Ligand [³H]PK11195 in Vulnerable Regions of the Rat Brain in Thiamine Deficiency Encephalopathy

1994 • 42 citations

Differential outcomes attenuate memory impairments on matching-to-position following pyrithiamine-induced thiamine deficiency in rats

1995 • 42 citations

Topographic distribution and severity of brain lesions in Wernicke's encephalopathy.

1987 • 41 citations

Monoamines and metabolites in cortex and subcortical structures: normal regional distribution and the effects of thiamine deficiency in the rat

1987 • 40 citations

Effects of Thiamin Deficiency on Acetylcholine Levels and Utilization in vivo in Rat Brain

1977 • 40 citations

Pathophysiologic mechanisms responsible for the reversible (thiamine‐responsive) and irreversible (thiamine non‐responsive) neurological symptoms of Wernicke's encephalopathy

1993 • 39 citations

Progression of neurological disease in thiamin-deficient rats is enhanced by ethanol

1990 • 39 citations

The locus coeruleus and memory: a study of chronic alcoholics with and without the memory impairment of Korsakoff's psychosis

1992 • 38 citations

Effects of pyrithiamin and oxythiamin on acetylcholine levels and utilization in rat brain

1978 • 38 citations

Central nervous system catecholamine metabolism in Korsakoff's psychosis

1984 • 37 citations

Serotonin and alcohol-related brain damage

1995 • 37 citations

Pathogenesis of diencephalic lesions in an experimental model of Wernicke's encephalopathy

1995 • 35 citations

Long-lasting changes in regional brain amino acids and monoamines in recovered pyrithiamine treated rats

1988 • 33 citations

Mechanisms of cell death in cholinergic basal forebrain neurons in chronic alcoholics

1995 • 32 citations

Neuronal Changes in the Cerebral Cortex of the Rat Following Alcohol Treatment and Thiamin Deficiency

1993 • 31 citations

Neuropathological correlates of memory dysfunction in the Wernicke-Korsakoff syndrome.

1994 • 31 citations

Polioencephalomalacia in goats.

1979 • 30 citations

Monoamine activity correlates with psychometric deficits in Korsakoff's disease

1985 • 29 citations

Thiamin Status in Australia1

2015 • 28 citations

Regional distribution of ethanol in rat brain

1976 • 27 citations

GABA-transaminase and glutamic acid decarboxylase changes in the brain of rats treated with pyrithiamine

1985 • 26 citations

Pyrithiamine-induced thiamine deficiency results in decreased Ca2+-dependent release of glutamate from rat hippocampal slices

1991 • 24 citations

Wernicke's encephalopathy in acquired immune deficiency syndrome (AIDS): a case report.

1989 • 23 citations

Necropsy study of GABA/benzodiazepine receptor binding sites in brain tissue from chronic alcoholic patients.

1988 • 23 citations

Alcohol-Related Thiamine Deficiency: Impact on Cognitive and Memory Functioning.

1995 • 22 citations

Cholinergic Therapy of Abnormal Open-Field Behavior in Thiamin-Deficient Rats

1982 • 22 citations

Reduced concentrations of arginine vasopressin and MHPG in lumbar CSF of patients with Korsakoff's psychosis

1986 • 18 citations

THE PATHOLOGY OF CHASTEK PARALYSIS IN FOXES, A COUNTERPART OF WERNICKEʼS HEMORRHAGIC POLIOENCEPHALITIS OF MAN

1944 • 17 citations

Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation

1995 • 16 citations

Commentary

1949 • 16 citations

Selective enrichment of cholinergic neurons with the α-ketoglutarate dehydrogenase complex in rat brain

1994 • 14 citations

Thiamin and Alzheimer's Disease

1992 • 14 citations

Persistence of habituation deficits after neurological recovery from severe thiamine deprivation

1987 • 13 citations

Thiamine deficiency neuropathy

1989 • 13 citations

Memory effect of dl-threo-3,4-dihydroxyphenylserine (DOPS) in human Korsakoff's disease

1988 • 13 citations

Reappraisal of regional thiamine content in the central nervous system of the normal and thiamine-deficient mice

1993 • 11 citations

Neuro-toxic interaction in alcohol-treated, thiamine-deficient mice

1987 • 11 citations

Metabolic studies of the edematous cerebral cortex of the pyrithiamine-treated thiamine-deficient rat

1988 • 10 citations

Transmitter amino acid neurochemistry in chronic alcoholism with and without cirrhosis of the liver

1993 • 10 citations

GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics.

1994 • 9 citations

Perseverative effects of parabrachial lesions: A mechanism of reduced activation?

1983 • 5 citations

[Experimental thiamine deficiency].

1983 • 3 citations