Pathogenesis of diencephalic lesions in an experimental model of Wernicke's encephalopathy

Excitotoxic cell death

1992 • 2,307 citations

Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain

1992 • 988 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

1992 • 814 citations

Trace Elements in Human Health and Disease

1977 • 753 citations

Histamine-immunoreactive nerve fibers in the rat brain

1989 • 631 citations

Neuropsychology of Memory

1992 • 625 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

The Relationships between Substrates and Enzymes of Glycolysis in Brain

1964 • 551 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

Cellular localization of a metabotropic glutamate receptor in rat brain

1992 • 539 citations

Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.

1992 • 507 citations

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

1971 • 409 citations

Handbook of clinical neurology

1970 • 388 citations

Organization of histaminergic fibers in the rat brain

1988 • 370 citations

The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations.

1971 • 350 citations

Excitatory amino acids and neuropsychiatrie disorders

1989 • 327 citations

Assessment of magnesium status.

1987 • 300 citations

Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma.

1988 • 252 citations

Glutamate-Induced Brain Damage in Infant Primates

1972 • 243 citations

Biochemical Characterization and Localization of a Non‐N‐Methyl‐D‐Aspartate Glutamate Receptor in Rat Brain

1992 • 242 citations

Alcoholic korsakoff's syndrome: Some unresolved issues concerning etiology, neuropathology, and cognitive deficits

1985 • 241 citations

Inciting Excitotoxic Cytocide Among Central Neurons

1986 • 231 citations

Ca2+-dependent and Ca2+- independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: Possible relevance to hyoglycaemia and anoxia

1988 • 228 citations

The Wernicke-Korsakoff Syndrome: A Clinical and Pathological Study of 245 Patients, 82 With Post-Mortem Examinations

1972 • 185 citations

Histamine potentiates N-methyl-d-aspartate responses in acutely isolated hippocampal neurons

1993 • 179 citations

Focal Cortical Seizures Cause Distant Thalamic Lesions

1982 • 172 citations

Encephalopathy of thiamine deficiency: studies of intracerebral mechanisms

1968 • 171 citations

Enhancement by histamine of NMDA-mediated synaptic transmission in the hippocampus

1993 • 169 citations

Neurotransmitter Actions in the Thalamus and Cerebral Cortex

1992 • 158 citations

Neurotoxicity at the N‐Methyl‐D‐Aspartate Receptor in Energy‐Compromised Neurons An Hypothesis for Cell Death in Aging and Disease

1989 • 157 citations

Protective effects of the glutamate antagonist MK-801 on pyrithiamine- induced lesions and amino acid changes in rat brain

1990 • 154 citations

Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain

1989 • 149 citations

Model of Wernicke's Encephalopathy

1981 • 148 citations

Thiamine deficiency in rats produces cognitive and memory deficits on spatial tasks that correlate with tissue loss in diencephalon, cortex and white matter

1995 • 147 citations

Effects of Thiamine Deficiency on the Central Nervous System

1961 • 146 citations

Correlation of enzymatic, metabolic, and behavioral deficits in thiamin deficiency and its reversal

1984 • 141 citations

Magnesium Deficiency in Alcoholism

1986 • 129 citations

Studies on the Physiological Functions of Thiamine

1961 • 123 citations

EFFECTS OF THIAMINE DEFICIENCY ON BRAIN METABOLISM: IMPLICATIONS FOR THE PATHOGENESIS OF THE WERNICKE-KORSAKOFF SYNDROME

1989 • 119 citations

Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency

1983 • 114 citations

Cerebral Vulnerability Is Associated with Selective Increase in Extracellular Glutamate Concentration in Experimental Thiamine Deficiency

1993 • 112 citations

Low Energy Levels in Thiamine-Deficient Encephalopathy

1984 • 110 citations

Extracellular Glutamate Is Increased in Thalamus During Thiamine Deficiency‐Induced Lesions and Is Blocked by MK‐801

1993 • 105 citations

Glial cell changes in the brain stem of thiamine-deficient rats.

1967 • 102 citations

Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms.

1992 • 102 citations

Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy 2. ?-ketoglutarate dehydrogenase

1986 • 100 citations

The induction and reversibility of cerebral acidosis in thiamine deficiency

1984 • 99 citations

Thiamine deficiency and wernicke's encephalopathy in AIDS

1991 • 97 citations

Ultrastructural features of early brain stem lesions of thiamine-deficient rats.

1968 • 96 citations

Comparative neuropsychology and Korsakoff's syndrome. III—Delayed response, delayed alternation and DRL performance

1982 • 95 citations

Excitotoxic Cytopathology, Progression, and Reversibility of Thiamine Deficiency-induced Diencephalic Lesions

1995 • 88 citations

Towards an understanding of the role of glutamate in neurodegenerative disorders: energy metabolism and neuropathology

1993 • 88 citations

SUBACUTE NECROTIZING ENCEPHALOMYELOPATHY

1975 • 86 citations

Alcoholic Korsakoff's Syndrome

1980 • 84 citations

Magnesium deficiency: a possible cause of thiamine refractoriness in Wernicke-Korsakoff encephalopathy

1974 • 82 citations

NEUROANATOMICAL CONSEQUENCES OF THIAMINE DEFICIENCY: A COMPARATIVE ANALYSIS

1985 • 74 citations

Early Edematous Lesion of Pyrithiamine Induced Acute Thiamine Deficient Encephalopathy in the Mouse

1978 • 69 citations

Edematous Necrosis in Thiamine-Deficient Encephalopathy of the Mouse

1981 • 64 citations

MK-801 prevents brain lesions and delayed-nonmatching-to-sample deficits produced by pyrithiamine-induced encephalopathy in rats.

1992 • 64 citations

Analysis of aversively conditioned learning and memory in rats recovered from pyrithiamine-induced thiamine deficiency.

1991 • 60 citations

Diencephalic lesions, learning impairments, and intact retrograde memory following acute thiamine deficiency in the rat

1992 • 58 citations

Fine structure of the early changes in the vestibular nuclei of the thiamine-deficient rat.

1968 • 56 citations

Impairment of olfactory, auditory, and spatial serial reversal learning in rats recovered from pyrithiamine-induced thiamine deficiency.

1991 • 54 citations

Disorders of pyruvate metabolism

1979 • 54 citations

Uptake of pyrithiamine by tissue of rats

1961 • 51 citations

MK-801 prevents brain lesions and delayed-nonmatching-to-sample deficits produced by pyrithiamine-induced encephalopathy in rats.

1992 • 50 citations

Aggravation of Thiamine Deficiency by Magnesium Depletion: A Case Report

1985 • 46 citations

Distribution of the α‐ketoglutarate dehydrogenase complex in rat brain

1994 • 46 citations

Thiamine deficiency in the cat leads to severe learning deficits and to widespread neuroanatomical damage

1982 • 44 citations

The effect of thiamine deficiency on the structure and physiology of the rat forebrain

1988 • 44 citations

Analysis of aversively conditioned learning and memory in rats recovered from pyrithiamine-induced thiamine deficiency.

1991 • 43 citations

Excitatory Actions of the Metabotropic Excitatory Amino Acid Receptor Agonist, trans‐(±)‐1‐amino‐cyclopentane‐1,3‐dicarboxylate (t‐ACPD), on Rat Thalamic Neurons In Vivo

1991 • 39 citations

Histamine‐mediated neuronal death in a rat model of Wernicke's encephalopathy

1994 • 36 citations

Subacute Necrotizing Encephalomyelopathy (LEIGH)

1970 • 33 citations

Cerebellar degeneration in thiamine-deficient rats.

1970 • 30 citations

Response latency and accuracy on a pretrained nonmatching-to-sample task in rats recovered from pyrithiamine-induced thiamine deficiency.

1991 • 29 citations

Multiple states of rat brain (RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors as revealed by quantitative autoradiography.

1992 • 29 citations

THE EFFECTS OF THIAMINE DEFICIENCY ON THE METABOLISM OF THE BRAIN–I. OXIDATION OF VARIOUS SUBSTRATES IN VITRO BY THE LIVER AND BRAIN OF NORMAL AND PYRITHIAMINE‐FED RATS*

1966 • 27 citations

Application of high field localised in vivo¹H MRS to study biochemical changes in the thiamin deficient rat brain under glucose load

1993 • 21 citations

Effect of Nimodipine on the Regional Cerebral Acidosis Accompanying Thiamine Deficiency in the Rat

1988 • 20 citations

Inhibitory effects of NMDA receptor antagonists on hypoxia-induced seizures in dietary Mg2+-deficient mice

1991 • 13 citations

Magnesium Deficiency and Magnesium Toxicity in Man

1976 • 12 citations

Symmetric Central Thalamic Necrosis in Experimental Thiamine Deficient Encephalopathy

1981 • 11 citations

Increased neuronal histamine in thiamine-deficient rats

1992 • 9 citations

Role of cofactors in the treatment of malnutrition as examplified by magnesium.

1975 • 9 citations

Thiamine-deficient encephalopathy in rats: Effects of deficiencies of thiamine and magnesium

1986 • 9 citations

The increase of histamine levels in the amygdala caused by histidine administration and the suppression of muricide in thiamine deficient rats

1989 • 4 citations