Thrombin receptor activation results in calcium signaling and protein kinase C-dependent stimulation of DNA synthesis in HEp-2g laryngeal carcinoma cells

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Fluorescent Probes of Cell Signaling

1989 • 649 citations

Platelets in Biology and Pathology

1981 • 644 citations

Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells

1980 • 424 citations

The mechanism of protein kinase C activation

1989 • 423 citations

Monocyte Chemotaxis: Stimulation by Specific Exosite Region in Thrombin

1983 • 333 citations

A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells

1994 • 205 citations

Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo.

1992 • 201 citations

A randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung cancer by the Cancer and Leukemia Group B.

1989 • 187 citations

Thrombin active site regions required for fibroblast receptor binding and initiation of cell division.

1980 • 186 citations

Influence of inositol 1,4,5-trisphosphate and guanine nucleotides on intracellular calcium release within the N1E-115 neuronal cell line.

1986 • 146 citations

The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets.

1986 • 129 citations

Mechanisms of Thrombin Receptor Agonist Specificity

1995 • 118 citations

Kinases and phosphatases in T-cell activation

1989 • 118 citations

Thrombin increases the metastatic potential of tumor cells

1993 • 111 citations

Solid tumor cells express functional "tethered ligand" thrombin receptor.

1995 • 79 citations

Immunologic analysis of the cloned platelet thrombin receptor activation mechanism: evidence supporting receptor cleavage, release of the N-terminal peptide, and insertion of the tethered ligand into a protected environment

1993 • 52 citations

Transcription of genes encoding granulocyte-macrophage colony-stimulating factor, interleukin 3, and interleukin 6 receptors and lack of proliferative response to exogenous cytokines in nonhematopoietic human malignant cell lines.

1993 • 31 citations

Protein kinase C inhibition by calmodulin and its fragments

1990 • 26 citations

Tenascin‐C induction by the diffusible factor epidermal growth factor in stromal‐epithelial interactions

1995 • 21 citations

Small Cell Carcinoma of the Lung: Interaction with the Blood Coagulation Mechanism and Treatment with Anticoagulants

1987 • 16 citations

The Anion-Binding Exosite is Critical for the High Affinity Binding of Thrombin to the Human Thrombin Receptor

1994 • 10 citations