When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

The chemistry and antioxidant properties of tocopherols and tocotrienols

1996 • 1,783 citations

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

1997 • 1,642 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

1994 • 1,274 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Towards the physiological function of uric acid

1993 • 824 citations

Antioxidants in relation to lipid peroxidation

1987 • 684 citations

Measurement of Plasma Hydroperoxide Concentrations by the Ferrous Oxidation-Xylenol Orange Assay in Conjunction with Triphenylphosphine

1994 • 657 citations

Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant

1992 • 513 citations

The Simultaneous Generation of Superoxide and Nitric Oxide Can Initiate Lipid Peroxidation in Human Low Density Lipoprotein

1992 • 460 citations

Presence of a modified low density lipoprotein in humans.

1988 • 373 citations

Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages

1993 • 311 citations

Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products

1990 • 245 citations

[23] Measurement of antioxidants in human blood plasma

1994 • 239 citations

Free radical metabolite of uric acid.

1988 • 226 citations

Low density lipoprotein is saturable by pro‐oxidant copper

1994 • 206 citations

Reduction of Copper, but Not Iron, by Human Low Density Lipoprotein (LDL)

1995 • 152 citations

Ascorbate and urate are the strongest determinants of plasma antioxidative capacity and serum lipid resistance to oxidation in Finnish men

1997 • 138 citations

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

1994 • 132 citations

Vitamin C prevents metal ion-dependent initiation and propagation of lipid peroxidation in human low-density lipoprotein

1995 • 126 citations

α-Tocopherol as a Reductant for Cu(II) in Human Lipoproteins

1996 • 117 citations

Green tea catechins such as (−)‐epicatechin and (−)‐epigallocatechin accelerate Cu²⁺‐induced low density lipoprotein oxidation in propagation phase

1997 • 116 citations

Exchange of oxidized cholesteryl linoleate between LDL and HDL mediated by cholesteryl ester transfer protein.

1995 • 109 citations

Copper Can Promote Oxidation of LDL by Markedly Different Mechanisms

1998 • 108 citations

Autoxidation in micelles. Synergism of vitamin C with lipid-soluble vitamin E and water-soluble Trolox

1985 • 107 citations

Prooxidant activity of caffeic acid, dietary non‐flavonoid phenolic acid, on Cu²⁺‐induced low density lipoprotein oxidation

1997 • 106 citations

Prooxidant role of vitamin E in copper induced lipid peroxidation

1993 • 93 citations

Inverse deuterium kinetic isotope effect for peroxidation in human low‐density lipoprotein (LDL): a simple test for tocopherol‐mediated peroxidation of LDL lipids

1995 • 70 citations

Simulation of the Induction of Oxidation of Low-Density Lipoprotein by High Copper Concentrations: Evidence for a Nonconstant Rate of Initiation

1997 • 50 citations

Ascorbic acid can either increase or decrease low density lipoprotein modification

1994 • 44 citations

The dynamic reduction of Cu(II) to Cu(I) and not Cu(I) availability is a sufficient trigger for low density lipoprotein oxidation

1997 • 26 citations

Unexpected Dose Response of Copper Concentration on Lipoprotein Oxidation in Serum: Discovery of A Unique Peroxidase-Like Activity of Urate/Albumin in the Presence of High Copper Concentrations

1997 • 25 citations

Cu(I) Availability Paradoxically Antagonizes Antioxidant Consumption and Lipid Peroxidation during the Initiation Phase of Copper-Induced LDL Oxidation

1998 • 24 citations

Different mechanisms are progressively recruited to promote Cu(II) reduction by isolated human low-density lipoprotein undergoing oxidation

1998 • 24 citations

Suitability of chemical in vitro models to investigate LDL oxidation: study with different initiating conditions in native and α-tocopherol-supplemented LDL

1997 • 14 citations

DNA breakage by uric acid and Cu(II): Binding of uric acid to DNA and biological activity of the reaction

1996 • 13 citations