Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy

Denaturant m values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding

1995 • 1,706 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

1991 • 882 citations

Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR

1988 • 823 citations

NMR evidence for an early framework intermediate on the folding pathway of ribonuclease A

1988 • 583 citations

[3] The preparation of guanidine hydrochloride

1972 • 540 citations

Protein Folding Studied Using Hydrogen-Exchange Labeling and Two-Dimensional NMR

1992 • 389 citations

The concept of a random coil: Residual structure in peptides and denatured proteins

1996 • 322 citations

Extremely rapid protein folding in the absence of intermediates

1995 • 282 citations

Thermodynamic and Kinetic Analysis of the SH3 Domain of Spectrin Shows a Two-State Folding Transition

1994 • 252 citations

Structure and dynamics of the acid-denatured molten globule state of .alpha.-lactalbumin: a two-dimensional NMR study

1993 • 248 citations

Pulsed H/D-exchange studies of folding intermediates

1993 • 245 citations

Folding and stability of a tryptophan-containing mutant of ubiquitin

1993 • 232 citations

Negative activation enthalpies in the kinetics of protein folding.

1995 • 224 citations

Following protein folding in real time using NMR spectroscopy

1995 • 223 citations

Submillisecond folding of monomeric lambda repressor.

1995 • 218 citations

Folding of chymotrypsin inhibitor 2. 2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding

1991 • 204 citations

Structural analysis of non-native states of proteins by NMR methods

1996 • 204 citations

Unfolded proteins, compact states and molten globules

1992 • 199 citations

Solution structure and ligand-binding site of the SH3 domain of the p85α subunit of phosphatidylinositol 3-kinase

1993 • 185 citations

Protein Folding Monitored at Individual Residues During a Two-Dimensional NMR Experiment

1996 • 172 citations

Structure and function of the SH3 domain

1994 • 168 citations

Structural Characterization of Folded and Unfolded States of an SH3 Domain in Equilibrium in Aqueous Buffer

1995 • 167 citations

Kinetics of interaction of partially folded proteins with a hydrophobic dye: Evidence that molten globule character is maximal in early folding intermediates

1995 • 160 citations

Kinetic analysis of folding and unfolding the 56 amino acid IgG-binding domain of streptococcal protein G

1992 • 158 citations

Kinetics of Folding of the IgG Binding Domain of Peptostreptoccocal Protein L

1997 • 155 citations

Direct NMR evidence for an intermediate preceding the rate-limiting step in the unfolding of ribonuclease A

1995 • 152 citations

Mechanism of Enzymatic and Nonenzymatic Prolyl Cis-Trans Isomerization

1993 • 148 citations

INSIGHTS INTO PROTEIN FOLDING FROM NMR

1996 • 145 citations

Folding of a four-helix bundle: studies of acyl-coenzyme A binding protein

1995 • 144 citations

The Folding Kinetics and Thermodynamics of the Fyn-SH3 Domain

1998 • 143 citations

A magnetization-transfer nuclear magnetic resonance study of the folding of staphylococcal nuclease

1989 • 133 citations

Folding and stability of a fibronectin type III domain of human tenascin

1997 • 109 citations

[22] Structural characterization of protein folding intermediates by proton magnetic resonance and hydrogen exchange

1989 • 105 citations

The effects of guanidine hydrochloride on the 'random coil' conformations and NMR chemical shifts of the peptide series GGXGG.

1997 • 100 citations

Stopped-flow NMR spectroscopy: real-time unfolding studies of 6-19F-tryptophan-labeled Escherichia coli dihydrofolate reductase.

1995 • 100 citations

Unfolded proteins, compact states and molten globules

1992 • 94 citations

NMR assignments as a basis for structural characterization of denatured states of globular proteins

1994 • 91 citations

Insights into protein folding using physical techniques: studies of lysozyme and α -lactalbumin

1995 • 91 citations

SH3 Domains: Molecular ‘Velcro’

1994 • 90 citations

Characterization of a folding intermediate of apoplastocyanin trapped by proline isomerization

1993 • 88 citations

Evidence for a Two-State Transition in the Folding Process of the Activation Domain of Human Procarboxypeptidase A2

1995 • 82 citations

Structure and Stability of Monomeric .lambda. Repressor: NMR Evidence for Two-State Folding

1995 • 80 citations

Stopped-Flow Photo-CIDNP Observation of Protein Folding

1997 • 78 citations

NMR and protein folding: Equilibrium and stopped‐flow studies

1993 • 73 citations

The rate of interconversion between the two unfolded forms of ribonuclease A does not depend on guanidinium chloride concentration

1979 • 71 citations

Protein folding kinetics from magnetization transfer nuclear magnetic resonance

1984 • 65 citations

A possible initial folding intermediate: the C-terminal proteolytic domain of tryptophan synthase .beta. chains folds in less than 4 milliseconds into a condensed state with non-native-like secondary structure

1992 • 61 citations

Folding of the disulfide-bonded β-sheet protein tendamistat: rapid two-state folding without hydrophobic collapse 1 1Edited by A. R. Fersht

1997 • 61 citations

Nuclear magnetic resonance evidence for a structural intermediate at an early stage in the refolding of ribonuclease A

1978 • 58 citations

Real-Time Refolding Studies of 6-¹⁹F-Tryptophan Labeled Escherichia coli Dihydrofolate Reductase Using Stopped-Flow NMR Spectroscopy

1996 • 48 citations

Protein folding intermediates with rapidly exchangeable amide protons contain authentic hydrogen-bonded secondary structures

1995 • 46 citations

Direct NMR Measurement of the Folding Kinetics of a Trimeric Peptide

1996 • 46 citations

Solvent isotope effects on the refolding kinetics of hen egg‐white lysozyme

1996 • 39 citations

Structural studies of a folding intermediate of bovine pancreatic ribonuclease A by continuous recycled flow

1988 • 34 citations

Temperature-jump NMR study of protein folding: Ribonuclease A at low pH

1991 • 30 citations

NMR analysis of staphylococcal nuclease thermal quench refolding kinetics

1993 • 23 citations