Lung Cell Oxidant Injury

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

The Respiratory Chain and Oxidative Phosphorylation

1956 • 2,073 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.

1981 • 757 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

1975 • 705 citations

Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen.

1980 • 678 citations

H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.

1975 • 653 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

H2O2 Release from Human Granulocytes during Phagocytosis

1977 • 586 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

METABOLIC PATTERNS IN THREE TYPES OF PHAGOCYTIZING CELLS

1963 • 500 citations

Superoxide dismutase and pulmonary oxygen toxicity

1974 • 462 citations

The Biology and Pathology of Oxygen Radicals

1978 • 437 citations

Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity

1976 • 430 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

DEVELOPMENT OF FINE STRUCTURAL DAMAGE TO ALVEOLAR AND CAPILLARY LINING CELLS IN OXYGEN-POISONED RAT LUNGS

1967 • 393 citations

Oxygen toxicity in neonatal and adult animals of various species

1978 • 386 citations

Normobaric Oxygen Toxicity of the Lung

1980 • 375 citations

Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes

1976 • 357 citations

Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system.

1975 • 317 citations

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

1981 • 280 citations

Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro

1979 • 280 citations

Isolation and Culture of Pulmonary Artery Endothelial Cells

1978 • 265 citations

Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.

1981 • 260 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Chemiluminescence and peroxidation

1975 • 249 citations

Oxygen toxicity

1980 • 238 citations

Role of oxygen metabolites in immune complex injury of lung.

1981 • 224 citations

Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis

1981 • 220 citations

Oxygen toxicity: augmentation of antioxidant defense mechanisms in rat lung

1976 • 216 citations

Pathologic changes in the lungs of oxygen-adapted rats: a morphometric analysis.

1978 • 213 citations

Pulmonary inflammation due to oxygen toxicity: involvement of chemotactic factors and polymorphonuclear leukocytes.

1981 • 211 citations

Stimulation of human neutrophils by soluble and insoluble immunoglobulin aggregates. Secretion of granule constituents and increased oxidation of glucose.

1975 • 206 citations

Human granulocyte generation of hydroxyl radical.

1978 • 191 citations

The alteration of superoxide dismutase, catalase, glutathione peroxidase, and NAD(P)H cytochrome c reductase in guinea pig polymorphonuclear leukocytes and alveolar macrophages during hyperoxia.

1976 • 189 citations

Hydroxyl radical generation by polymorphonuclear leukocytes measured by electron spin resonance spectroscopy.

1979 • 156 citations

The role of superoxide in the destruction of erythrocyte targets by human neutrophils.

1980 • 156 citations

The effect of oxygen tension on the growth and metabolism of WI‐38 cells

1976 • 151 citations

Clonal isolation of differentiated rat lung cells

1974 • 142 citations

Effects of Phorbol Myristate Acetate on the Metabolism and Ultrastructure of Neutrophils in Chronic Granulomatous Disease

1974 • 127 citations

The myeloperoxidase-hydrogen peroxide-halide system as effector of neutrophil-mediated tumor cell cytotoxicity.

1981 • 116 citations

Suppression by superoxide dismutase of immune-complex--induced pulmonary alveolitis and dermal inflammation.

1981 • 100 citations

Comparative aspects of oxidative metabolism of neutrophils from human blood and guinea pig peritonea: Magnitude of the respiratory burst, dependence upon stimulating agents, and localization of the oxidases

1980 • 79 citations

EPR studies on reduction of oxygen to superoxide by some biochemical systems

1969 • 63 citations

Endothelial regeneration as a marker of the differential vascular responses in oxygen-induced pulmonary edema.

1974 • 62 citations

Oxygen Effect on Lung Cells

1971 • 56 citations

Mechanisms of pulmonary injury

1974 • 55 citations

INTERNATIONAL CONFERENCE ON SINGLET OXYGEN AND RELATED SPECIES IN CHEMISTRY AND BIOLOGY REVIEW AND GENERAL DISCUSSION†,‡

1978 • 39 citations

Depression of serotonin uptake by cultured endothelial cells exposed to high O2 tension

1981 • 39 citations

Bioenergetic Pattern of Isolated Type II Pneumocytes in Air and during Hypoxia

1978 • 38 citations

Evidence for the role of superoxide radicals in neutrophil-mediated cytotoxicity.

1979 • 37 citations

Impairment of phagocytosis by moderate hyperoxia (40 to 60 per cent oxygen) in lung macrophages.

1980 • 35 citations

Differences in oxygen‐dependent regulation of enzymes between tumor and normal cell systems in culture

1981 • 33 citations

Isolation and culture of endothelial cells from the lungs of small animals.

1979 • 32 citations

Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes

1976 • 23 citations

An ultrastructural study of alveolar permeability to cytochrome C in the rabbit lung: effect of exposure to 100% oxygen at one atmosphere.

1981 • 21 citations

Effects of high oxygen exposure on bioenergetics in isolated type II pneumocytes

1979 • 19 citations

The effect of hyperoxia on phagocytosis and pinocytosis in isolated pulmonary macrophages.

1978 • 19 citations

Effect of hyperoxia, hypoxia, and maturation on superoxide dismutase activity in isolated alveolar macrophages.

1977 • 16 citations

Oxygen effect on lung cells

1971 • 14 citations

Basic Aspects of Pulmonary Dysfunction as Related to Hemotherapy

2015 • 5 citations

Mechanisms of pulmonary injury

1974 • 1 citations