Free radicals and environmental toxins

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

How super is superoxide?

1981 • 1,294 citations

Iron Transport and Storage Proteins

1980 • 1,183 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

Carbon Tetrachloride Hepatotoxicity: An Example of Lethal Cleavage

1973 • 729 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

1977 • 545 citations

Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity

1974 • 540 citations

Ferritin and superoxide-dependent lipid peroxidation.

1985 • 532 citations

Chemicals, Drugs, and Lipid Peroxidation

1976 • 520 citations

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

1979 • 492 citations

Ethane Evolution: A New Index of Lipid Peroxidation

1974 • 449 citations

Low molecular weight intracellular iron transport compounds

1977 • 389 citations

Cardiotoxicity of adriamycin and related anthracyclines

1976 • 377 citations

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

1975 • 306 citations

The Toxicity of Paraquat

1966 • 263 citations

The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron

1983 • 234 citations

Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein

1969 • 223 citations

Mechanism and kinetics of iron release from ferritin by dihydroflavins and dihydroflavin analogs

1978 • 194 citations

Structure, Synthesis and Function of Glutathione Peroxidase

2009 • 178 citations

Free radicals in pharmacology and toxicology--selected topics.

1981 • 167 citations

Reduction of paraquat toxicity by superoxide dismutase

1974 • 165 citations

THE MECHANISM OF IRON RELEASE FROM FERRITIN AS RELATED TO ITS BIOLOGICAL PROPERTIES

1955 • 151 citations

Nuclear catalyzed antibiotic free radical formation.

1982 • 149 citations

Chemical Mechanisms in Carbon Tetrachloride Toxicity

1977 • 136 citations

Ferritin iron uptake and release. Structure–function relationships

1974 • 133 citations

Pulse radiolysis studies of antitumor quinones: Radical lifetimes, reactivity with oxygen, and one-electron reduction potentials

1981 • 124 citations

Ferritin: an iron-storage molecule.

1977 • 118 citations

Liver parenchymal cell injury. IV. Pattern of incorporation of carbon and chlorine from carbon tetrachloride into chemical constituents of liver in vivo.

1967 • 115 citations

Effect of ferritin-containing fractions with different iron loading on lipid peroxidation

1983 • 114 citations

The catalytic activity of horse spleen apoferritin. Preliminary kinetic studies and the effect of chemical modification

1973 • 113 citations

Iron chelation prevents tissue injury following ischemia

1985 • 109 citations

On the formation of the superoxide anion radical during the reaction of reduced iron-sulfur proteins with oxygen

1969 • 105 citations

Iron mobilization from ferritin by chelating agents

1980 • 89 citations

Paraquat toxicity is enhanced by iron and reduced by desferrioxamine in laboratory mice

1985 • 85 citations

Reductive oxygenation of carbon tetrachloride: Trichloromethylperoxyl radical as a possible intermediate in the conversion of carbon tetrachloride to electrophilic chlorine

1983 • 82 citations

Self-catalysed, O2-independent inactivation of nadph- or dithionite-reduced microsomal cytochrome P-450 by carbon tetrachloride

1981 • 70 citations

Paraquat and ferritin-dependent lipid peroxidation

1985 • 59 citations

Alterations of specific forms of cytochrome P-450 in rat liver during acute carbon tetrachloride intoxication

1981 • 57 citations

Biochemical basis for the in vitro pro-oxidant action of carbon tetrachloride

1969 • 56 citations

Regulation of ferritin mRNA: a possible gene-sparing phenomenon. Induction of ferritin synthesis by iron in liver as well as red cells combines high translational efficiency with increased utilization of preformed ferritin mRNA.

1983 • 47 citations

Effects of Induction of Cytochrome P-450 Enzymes on the Concentration of Foreign Compounds and Their Metabolites and on the Toxicological Effects of These Compounds

1979 • 47 citations

Phase II and pharmacokinetic study of aziridinylbenzoquinone [2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone, diaziquone, NSC 182986] in high-grade gliomas.

1983 • 40 citations

Phosphate compounds in rat erythrocytes and reticulocytes

1976 • 33 citations

The effect of superoxide dismutase on paraquat mortality in mice and rats

1982 • 31 citations

Release of ferrous iron from ferritin by liver microsomes: a possible role in the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1984 • 30 citations

Differences in the nature of induction of mixed-function oxidase systems of the rat liver among phenobarbital, DDT, 3-methylcholanthrene, and TCDD

1981 • 25 citations

Free radicals in NADPH-microsomes-triphenyltetrazolium chloride system as evidenced by initiation of sulfite oxidation

1967 • 17 citations