Schizophrenia as a neurodevelopmental disorder

The neuropathology of schizophrenia

1999 • 1,664 citations

Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

2000 • 1,565 citations

Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

1982 • 1,352 citations

The reduced neuropil hypothesis: a circuit based model of schizophrenia

1999 • 918 citations

Growth patterns in the developing brain detected by using continuum mechanical tensor maps

2000 • 860 citations

Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity

2000 • 647 citations

Behavioral and Intellectual Markers for Schizophrenia in Apparently Healthy Male Adolescents

1999 • 576 citations

Compromised White Matter Tract Integrity in Schizophrenia Inferred From Diffusion Tensor Imaging

1999 • 461 citations

The Initial Prodrome in Schizophrenia: Searching for Naturalistic Core Dimensions of Experience and Behavior

2000 • 456 citations

Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia

1999 • 383 citations

The Inheritance of Neuropsychological Dysfunction in Twins Discordant for Schizophrenia

2000 • 375 citations

Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging

1999 • 370 citations

Magnetic resonance imaging of brain in people at high risk of developing schizophrenia

1999 • 362 citations

Mathematical/computational challenges in creating deformable and probabilistic atlases of the human brain

2000 • 338 citations

Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “Two hit hypothesis”

1999 • 329 citations

Hypothesis: Is low prenatal vitamin D a risk-modifying factor for schizophrenia?

1999 • 327 citations

Cognitive and behavioral precursors of schizophrenia

1999 • 317 citations

Alterations in Chandelier Neuron Axon Terminals in the Prefrontal Cortex of Schizophrenic Subjects

1999 • 293 citations

Maternal Exposure to Respiratory Infections and Adult Schizophrenia Spectrum Disorders: A Prospective Birth Cohort Study

2000 • 266 citations

Development, disease and degeneration in schizophrenia: a unitary pathophysiological model

1999 • 263 citations

Childhood Cognitive Functioning in Schizophrenia Patients and Their Unaffected Siblings: A Prospective Cohort Study

2000 • 250 citations

Thalamic and amygdala–hippocampal volume reductions in first-degree relatives of patients with schizophrenia: an MRI-based morphometric analysis

1999 • 248 citations

School Performance in Finnish Children and Later Development of Schizophrenia

1999 • 246 citations

Childhood-onset schizophrenia: progressive brain changes during adolescence

1999 • 221 citations

Hypoxic-Ischemia-Related Fetal/Neonatal Complications and Risk of Schizophrenia and Other Nonaffective Psychoses: A 19-Year Longitudinal Study

2000 • 210 citations

A Prospective Cohort Study of Genetic and Perinatal Influences in the Etiology of Schizophrenia

2000 • 209 citations

Sensory Gating Deficits Assessed by the P50 Event-Related Potential in Subjects With Schizotypal Personality Disorder

2000 • 200 citations

Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk

2000 • 194 citations

How hallucinations may arise from brain mechanisms of learning, attention, and volition

2000 • 185 citations

Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure

1999 • 169 citations

Obstetric Risk Factors for Early-Onset Schizophrenia in a Finnish Birth Cohort

2000 • 160 citations

Childhood Neuromotor Dysfunction in Schizophrenia Patients and Their Unaffected Siblings: A Prospective Cohort Study

2000 • 153 citations

Premorbid Speech and Language Impairments in Childhood-Onset Schizophrenia: Association With Risk Factors

2000 • 152 citations

The imbalanced brain: from normal behavior to schizophrenia

2000 • 150 citations

Duration of untreated psychosis and 12‐month outcome in first‐episode psychosis: the impact of treatment approach

1999 • 145 citations

Wisconsin Card Sorting Test deficits in schizotypic individuals

1999 • 145 citations

Velocardiofacial Syndrome in Childhood-Onset Schizophrenia

1999 • 144 citations

A Prospective Cohort Study of Childhood Behavioral Deviance and Language Abnormalities as Predictors of Adult Schizophrenia

2000 • 142 citations

Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter

1999 • 136 citations

Obstetric complications and congenital malformation in schizophrenia

2000 • 132 citations

Hippocampal volume reduction in schizophrenia: effects of genetic risk and pregnancy and birth complications

1999 • 129 citations

Neurodevelopmental abnormalities in schizophrenia: Insights from neuropathology

1999 • 125 citations

Mapping Morphology of the Corpus Callosum in Schizophrenia

2000 • 115 citations

Investigation of frontal lobe subregions in first-episode schizophrenia1This study was presented in part at the 1996 Meeting of the Society for Research in Psychopathology in Atlanta, GA, and the 1997 Meeting of the International Congress on Schizophrenia Research in Colorado Springs, CO.1

1999 • 106 citations

P300 subcomponent abnormalities in schizophrenia: III. Deficits in unaffected siblings of schizophrenic probands

2000 • 104 citations

Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia

2000 • 100 citations

Attentional deficits in patients with schizophrenia and in their non-psychotic first-degree relatives

1999 • 88 citations

Cumulative effect of anatomical risk factors for schizophrenia: an MRI study

1999 • 86 citations

Early cerebro-craniofacial dysmorphogenesis in schizophrenia: a lifetime trajectory model from neurodevelopmental basis to ‘neuroprogressive’ process

1999 • 83 citations

A prospective cohort study of neurodevelopmental processes in the genesis and epigenesis of schizophrenia

1999 • 83 citations

The effect of family status and schizotypy on electrophysiologic measures of attention and semantic processing

2000 • 82 citations

Auditory working memory and verbal recall memory in schizotypy

2000 • 81 citations

Visuospatial working memory in schizotypal personality disorder patients

2000 • 75 citations

Can we improve the diagnostic efficiency and predictive power of prodromal symptoms for schizophrenia?

2000 • 73 citations

Neuropsychological function in subjects with psychotic and affective disorders. Relationship to diagnostic category and duration of illness

2000 • 73 citations

Visual Perception and Working Memory in Schizotypal Personality Disorder

2000 • 72 citations

Premorbid IQ in patients with functional psychosis and their first-degree relatives

2000 • 68 citations

The genetics of mental illness: implications for practice.

2000 • 64 citations

The developmental ‘risk factor’ model of schizophrenia

1999 • 62 citations

Clinical and Neurobiological Correlates of Cytogenetic Abnormalities in Childhood-Onset Schizophrenia

1999 • 62 citations

Seasonality and infectious disease in schizophrenia: the birth hypothesis revisited

1999 • 61 citations

Neurobiological findings in early phase schizophrenia

2000 • 60 citations

Two-point discrimination thresholds and schizotypy: illuminating a somatosensory dysfunction

2000 • 57 citations

Large CSF Volume Not Attributable to Ventricular Volume in Schizotypal Personality Disorder

2000 • 55 citations

Developmental neuropathology and the precursors of schizophrenia

1999 • 52 citations

Communication Disturbances in Relatives Beyond the Age of Risk for Schizophrenia and Their Associations With Symptoms in Patients

1999 • 51 citations

Dual Cytoarchitectonic Trends: An Evolutionary Model of Frontal Lobe Functioning and Its Application to Psychopathology

2000 • 50 citations

Early detection and treatment delay: implications for outcome in early psychosis

2000 • 47 citations

A Twin Study of Communication Disturbances in Schizophrenia

2000 • 45 citations

Changes in adult brain and behavior caused by neonatal limbic damage: implications for the etiology of schizophrenia

2000 • 44 citations

Neuropsychological functioning among non-psychotic siblings and parents of schizophrenic patients

1999 • 42 citations

Eye-tracking dysfunction (ETD) in families with sporadic and familial schizophrenia

2000 • 35 citations

Moving beyond findings: concepts and model-building in schizophrenia

1999 • 29 citations

Type of feeding during infancy and later development of schizophrenia

2000 • 28 citations

Cognition and neuropathology in schizophrenia

1999 • 28 citations

Obstetric complications in schizophrenia, schizoaffective disorder and normal comparison subjects

1999 • 22 citations

Early diagnosis of schizophrenia - the first step towards secondary prevention

2000 • 21 citations

Schizophrenia: syndromes and diseases

1999 • 18 citations

Neurobiological abnormalities in the relatives of schizophrenics

1999 • 4 citations