Conserved Binding Mode of Human β₂ Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

High-Resolution Crystal Structure of an Engineered Human β ₂ -Adrenergic G Protein–Coupled Receptor

2007 • 3,186 citations

Structure of a β1-adrenergic G-protein-coupled receptor

2008 • 1,310 citations

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

2008 • 910 citations

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

2010 • 454 citations

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

2008 • 447 citations

Structure-based discovery of β ₂ -adrenergic receptor ligands

2009 • 278 citations

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

2009 • 240 citations

Analysis of full and partial agonists binding to β₂‐adrenergic receptor suggests a role of transmembrane helix V in agonist‐specific conformational changes

2009 • 119 citations

Dynamics of the β₂-Adrenergic G-Protein Coupled Receptor Revealed by Hydrogen−Deuterium Exchange

2010 • 117 citations

Insights into signaling from the β2-adrenergic receptor structure

2008 • 92 citations

Plasmon-Waveguide Resonance Studies of Ligand Binding to the Human β₂-Adrenergic Receptor

2004 • 62 citations

Identifying conformational changes of the β2 adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

2009 • 61 citations

Ligand and structure‐based models for the prediction of ligand‐receptor affinities and virtual screenings: Development and application to the β₂‐adrenergic receptor

2009 • 46 citations

Analysis of hydrophobic interactions of antagonists with the beta2-adrenergic receptor

2010 • 9 citations