A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

High-Resolution Crystal Structure of an Engineered Human β ₂ -Adrenergic G Protein–Coupled Receptor

2007 • 3,186 citations

[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors

1995 • 2,811 citations

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

2007 • 1,885 citations

GPCR Engineering Yields High-Resolution Structural Insights into β ₂ -Adrenergic Receptor Function

2007 • 1,322 citations

How Cells Handle Cholesterol

2000 • 1,230 citations

How lipids affect the activities of integral membrane proteins

2004 • 1,141 citations

Peripheral-Type Benzodiazepine Receptor Function in Cholesterol Transport. Identification of a Putative Cholesterol Recognition/Interaction Amino Acid Sequence and Consensus Pattern¹

1998 • 567 citations

Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae

2000 • 514 citations

Cholesterol as Modulator of Receptor Function

1997 • 456 citations

Microscale Fluorescent Thermal Stability Assay for Membrane Proteins

2008 • 439 citations

Timolol

1977 • 384 citations

Inverse agonist activity of beta-adrenergic antagonists.

1994 • 357 citations

Identification of G protein‐coupled receptor genes from the human genome sequence

2002 • 355 citations

Regulation of receptor function by cholesterol

2000 • 302 citations

A role for direct interactions in the modulation of rhodopsin by ω-3 polyunsaturated lipids

2006 • 294 citations

Role of cholesterol in the function and organization of G-protein coupled receptors

2006 • 282 citations

Internal packing of helical membrane proteins

2000 • 260 citations

Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase

2001 • 254 citations

Characterization of the Cholesterol Recognition Amino Acid Consensus Sequence of the Peripheral-Type Benzodiazepine Receptor

2004 • 236 citations

Cholesterol modulates ligand binding and G-protein coupling to serotonin1A receptors from bovine hippocampus

2004 • 235 citations

Comparison of Helix Interactions in Membrane and Soluble α-Bundle Proteins

2002 • 214 citations

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.

1996 • 190 citations

Agonist and Inverse Agonist Actions of β-Blockers at the Human β₂-Adrenoceptor Provide Evidence for Agonist-Directed Signaling

2003 • 186 citations

The Crystal Structure of a Hyperthermophilic Archaeal TATA-box Binding Protein

1996 • 170 citations

Caveolin Scaffolding Region and Cholesterol-rich Domains in Membranes

2004 • 150 citations

Lipid composition of Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) insect cells used for baculovirus infection

1998 • 149 citations

A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases

2004 • 147 citations

Manipulation of Cholesterol Levels in Rod Disk Membranes by Methyl-β-cyclodextrin

2002 • 141 citations

Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure

2007 • 134 citations

Occluded molecular surface: Analysis of protein packing

1995 • 117 citations

Cholesterol as stabilizer of the oxytocin receptor

2002 • 115 citations

Juxtamembrane Protein Segments that Contribute to Recruitment of Cholesterol into Domains

2006 • 111 citations

Membrane Cholesterol Modulates Galanin−GalR2 Interaction

1999 • 99 citations

The PDZ-binding motif of the β ₂ -adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes

2003 • 91 citations

?2-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts*1

2004 • 75 citations

Using synthetic lipids to stabilize purified β2 adrenoceptor in detergent micelles

2005 • 67 citations

Why are there so many adrenoceptor subtypes?

1994 • 50 citations

Mutation of Asn293 to Asp in Transmembrane Helix VI Abolishes Agonist-Induced but Not Constitutive Activity of the β₂-Adrenergic Receptor

2002 • 26 citations