Pravastatin suppresses the interleukin‐8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase
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References (48)
Atherosclerosis — An Inflammatory Disease
1999 • 21,494 citations
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
1994 • 8,631 citations
The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
1996 • 7,450 citations
Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
1995 • 7,378 citations
Regulation of the mevalonate pathway
1990 • 5,282 citations
Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels
1998 • 5,229 citations
PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA
1995 • 3,524 citations
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
1994 • 2,615 citations
Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
2014 • 1,880 citations
All ras proteins are polyisoprenylated but only some are palmitoylated
1989 • 1,806 citations
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
1999 • 1,228 citations
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
1998 • 978 citations
Influence of Pravastatin and Plasma Lipids on Clinical Events in the West of Scotland Coronary Prevention Study (WOSCOPS)
1998 • 804 citations
Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells.
1998 • 767 citations
Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1
1995 • 733 citations
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
1998 • 525 citations
Posttranslational modification of proteins by isoprenoids in mammalian cells
1990 • 515 citations
Reduction of Stroke Incidence After Myocardial Infarction With Pravastatin
1999 • 439 citations
Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall
1996 • 336 citations
3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Increase Fibrinolytic Activity in Rat Aortic Endothelial Cells
1998 • 313 citations
Interleukin-8. A mitogen and chemoattractant for vascular smooth muscle cells.
1994 • 259 citations
Interleukin 8 Is Induced by Cholesterol Loading of Macrophages and Expressed by Macrophage Foam Cells in Human Atheroma
1996 • 251 citations
Enhanced production of the chemotactic cytokines interleukin-8 and monocyte chemoattractant protein-1 in human abdominal aortic aneurysms.
1993 • 237 citations
Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types
1997 • 218 citations
Potential Mechanisms for a Proinflammatory Vascular Cytokine Response to Coagulation Activation
1998 • 213 citations
Interleukin-8 and MCAF: Novel Leukocyte Recruitment and Activating Cytokines
2015 • 210 citations
Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression.
1997 • 152 citations
Cellular and Molecular Abnormalities in the Vascular Endothelium of Diabetes Mellitus
1994 • 129 citations
Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells
1999 • 117 citations
Cerivastatin Suppresses Lipopolysaccharide-Induced ICAM-1 Expression through Inhibition of Rho GTPase in BAEC
2000 • 107 citations
Thrombin activates nuclear factor-kappaB and potentiates endothelial cell activation by TNF.
1997 • 105 citations
Lovastatin Induces Apoptosis in Malignant Mesothelioma Cells
1998 • 104 citations
Thrombin stimulates production of interleukin‐8 in human umbilical vein endothelial cells
1996 • 101 citations
Potent and specific inhibition of IL-8-, IL-1α- and IL-1β-inducedin vitro human lymphocyte migration by calcium channel antagonists
1989 • 95 citations
Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis
1994 • 89 citations
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells
1998 • 85 citations
Cooling and Rewarming-Induced IL-8 Expression in Human Bronchial Epithelial Cells through p38 MAP Kinase-Dependent Pathway
1998 • 75 citations
Cross-linking of Intercellular Adhesion Molecule-1 Induces Interleukin-8 and RANTES Production through the Activation of MAP Kinases in Human Vascular Endothelial Cells
1998 • 74 citations
Interleukin-8 and MCAF: Novel Leukocyte Recruitment and Activating Cytokines (Part 1 of 2)
1992 • 70 citations
Fibrinopeptide-A in Diabetes Mellitus: Relation to Levels of Blood Glucose, Fibrinogen Disappearance, and Hemodynamic Changes
1985 • 62 citations
Endothelial Cell Tyrosine Kinase Receptor and G Protein–Coupled Receptor Activation Involves Distinct Protein Kinase C Isoforms
1996 • 58 citations
Interleukin-8 is chemotactic for vascular smooth muscle cells
1993 • 56 citations
High glucose enhances the gene expression of interleukin-8 in human endothelial cells, but not in smooth muscle cells: possible role of interleukin-8 in diabetic macroangiopathy
1997 • 41 citations
Inhibition of MAP kinase kinase (MEK) blocks endothelial PGI2 release but has no effect on von Willebrand factor secretion or E‐selectin expression
1996 • 40 citations
Fibrinopeptide-A in diabetes mellitus. Relation to levels of blood glucose, fibrinogen disappearance, and hemodynamic changes
1985 • 36 citations
The IL-8 Production in Endothelial Cells is Stimulated by High Glucose
1996 • 22 citations
Mechanical Stretch Activates a Pathway Linked to Mevalonate Metabolism in Cultured Neonatal Rat Heart Cells.
1998 • 22 citations
Activation of Ras by phorbol esters in cardiac myocytes
1999 • 17 citations