Interleukin 8 Is Induced by Cholesterol Loading of Macrophages and Expressed by Macrophage Foam Cells in Human Atheroma

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes

1992 • 2,655 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

The pathogenesis of coronary artery disease and the acute coronary syndromes (First of two parts)

1992 • 1,958 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque.

1986 • 1,323 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes

1989 • 1,060 citations

Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

1984 • 994 citations

Monocyte chemoattractant protein-1 in human atheromatous plaques.

1991 • 892 citations

Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

1991 • 879 citations

Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.

1982 • 797 citations

Detection of activated T lymphocytes in the human atherosclerotic plaque.

1989 • 739 citations

Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1

1995 • 599 citations

Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization.

1991 • 593 citations

The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively‐charged LDL by macrophages

1980 • 543 citations

Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages.

1980 • 475 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms.

1995 • 428 citations

Angiogenesis in human coronary atherosclerotic plaques.

1994 • 273 citations

Interleukin-8. A mitogen and chemoattractant for vascular smooth muscle cells.

1994 • 259 citations

Enhanced production of the chemotactic cytokines interleukin-8 and monocyte chemoattractant protein-1 in human abdominal aortic aneurysms.

1993 • 237 citations

Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035.

1984 • 230 citations

Expression of a monocyte chemotactic cytokine by human mononuclear phagocytes

1991 • 199 citations

A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.

1993 • 184 citations

Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment.

1995 • 184 citations

An immunohistochemical analysis of human aortic fatty streaks

1987 • 177 citations

Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity.

1994 • 161 citations

Expression of a monocyte chemotactic cytokine by human mononuclear phagocytes.

1992 • 155 citations

Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages.

1990 • 143 citations

Identification of foam cells in human atherosclerotic lesions as macrophages using monoclonal antibodies.

1985 • 122 citations

The role of macrophages in atherogenesis

1993 • 121 citations

Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase

1994 • 102 citations

Induction of acetyl-LDL receptor activity by phorbol ester in human monocyte cell line THP-1.

1989 • 92 citations

Induction of acetylated low density lipoprotein receptor and suppression of low density lipoprotein receptor on the cells of human monocytic leukemia cell line (THP-1 cell)

1987 • 86 citations

Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages.

1992 • 83 citations

Expression of elastase activity by human monocyte-macrophages is modulated by cellular cholesterol content, inflammatory mediators, and phorbol myristate acetate.

1990 • 72 citations

THP-1 cells form foam cells in response to coculture with lipoproteins but not platelets.

1991 • 70 citations

Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a) internalization and degradation.

1993 • 65 citations

Angiogenesis in atherosclerosis.

1992 • 63 citations

Effect of corticosteroids, cyclosporin A, and methotrexate on cytokine release from monocytes and T-cell subsets

1994 • 59 citations

Interleukin-8 is chemotactic for vascular smooth muscle cells

1993 • 56 citations

Incubation of acetylated low-density lipoprotein with cholesterol-rich dispersions enhances cholesterol uptake by macrophages

1987 • 46 citations

The secretion of apolipoprotein E by human monocytederived macrophages

1985 • 44 citations

Calcium ionophore A23187 induces interleukin‐8 gene expression and protein secretion in human monocytic cells

1993 • 32 citations

Cholesteryl ester loading of mouse peritoneal macrophages is associated with changes in the expression or modification of specific cellular proteins, including increase in an alpha-enolase isoform.

1993 • 31 citations

Compartmentation of cholesterol within the cell

1994 • 26 citations

The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction.

1989 • 25 citations

Immunohistochemical Demonstration of 15-Lipoxygenase in Transplant Coronary Artery Disease

1995 • 15 citations