The mode of action of aspirin and similar compounds

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

1971 • 1,433 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

1971 • 940 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

Prostaglandins, Aspirin-like Drugs and Analgesia

1972 • 871 citations

Advances in Prostaglandin and Thromboxane Research

1976 • 840 citations

Intolerance to Aspirin

1968 • 837 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

1972 • 773 citations

THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUES

1971 • 658 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.

1975 • 490 citations

Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation

1973 • 485 citations

Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis

1972 • 478 citations

New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs

1974 • 427 citations

Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets

1975 • 393 citations

Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits

1971 • 358 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 339 citations

Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation

1973 • 318 citations

Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs

1973 • 296 citations

Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs

1997 • 295 citations

Prostaglandins, peptides and amines,

1969 • 295 citations

Prostaglandin Synthetase Inhibitors I

1979 • 279 citations

Inhibition of prostaglandin synthesis in man

1972 • 276 citations

Effect of Prostaglandin E1 on Adjuvant Arthritis

1971 • 264 citations

Corticosteroids inhibit prostaglandin production by rheumatoid synovia

1975 • 261 citations

Prostaglandins in Cellular Biology

1972 • 260 citations

Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids

1975 • 239 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 233 citations

Observations on the Effects of Infusion of Prostnglnndin E in Man

1959 • 232 citations

Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea pig lung

1974 • 226 citations

Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea‐pig lungs

1973 • 223 citations

PROSTAGLANDIN SYNTHETASE INHIBITORS

1979 • 220 citations

Bronchial Hyperreactivity to Prostaglandin F2 and Histamine in Patients with Asthma

1973 • 217 citations

Recovery of Prostaglandins in Human Cutaneous Inflammation

1971 • 206 citations

SITE OF ACTION OF NARCOTIC AND NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN.

1964 • 206 citations

Pyrogen fever and prostaglandin‐like activity in cerebrospinal fluid

1973 • 204 citations

PROSTAGLANDIN E₁: A POTENTIAL MEDIATOR OF THE INFLAMMATORY RESPONSE

1971 • 203 citations

Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint

1975 • 196 citations

Prostaglandin endoperoxides IV. Effects on smooth muscle

1975 • 193 citations

Urticaria and asthma induced by food-and-drug additives in patients with aspirin hypersensitivity

1972 • 193 citations

Prostaglandin on Cutaneous Vasculature**From the Department of Dermatology, College of Medicine, University of Illinois.

1968 • 191 citations

Biochemistry of the acute allergic reactions

1969 • 190 citations

Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused rabbit ear

1974 • 183 citations

Prostaglandin Endoperoxides IX. Characterization of Rabbit Aorta Contracting Substance (RCS) from Guinea Pig Lung and Human Platelets

1975 • 179 citations

Fever produced by prostaglandin E₁

1971 • 178 citations

Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias*

2006 • 174 citations

Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine.

1973 • 168 citations

Pharmacologic Agents Released in Ultraviolet Inflammation Studied by Continuous Skin Perfusion

1970 • 167 citations

A histopathological and pharmacological analysis of the mode of action of non‐steroidal anti‐inflammatory drugs

1971 • 165 citations

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

1971 • 163 citations

A CHEMOTACTIC ROLE FOR PROSTAGLANDINS RELEASED FROM POLYMORPHONUCLEAR LEUCOCYTES DURING PHAGOCYTOSIS

1975 • 154 citations

Release of Prostaglandins in Ocular Inflammation in the Rabbit

1972 • 146 citations

Action of Prostaglandin E1 on Tissues which respond to Bradykinin

1963 • 139 citations

An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia

1976 • 137 citations

Aspirin intolerance. III. Subtypes, familial occurrence, and cross-reactivity with tartrazine

1975 • 136 citations

Itch: Role of Prostaglandins

1973 • 135 citations

Antagonism by Fenamates of Prostaglandin F2α and of Slow Reacting Substance on Human Bronchial Muscle

1968 • 133 citations

Future Trends in Inflammation

1975 • 132 citations

Prostaglandin-like Activity in Ocular Inflammation

1972 • 131 citations

XXXII. An account of the success of the bark of the willow in the cure of agues. In a letter to the Right Honourable George Earl of Macclesfield, President of R. S. from the Rev. Mr. Edward Stone, of Chipping-Norton in Oxfordshire

1763 • 129 citations

A Possible Basis for the Anti-inflammatory Activity of Salicylates and other Non-Hormonal Anti-Rheumatic Drugs

1958 • 126 citations

Immunologic Release of Histamine and Slow Reacting Substance of Anaphylaxis from Human Lung

1973 • 124 citations

Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen

1973 • 124 citations

ACTION OF PROSTAGLANDIN IN THE PREGNANT WOMAN

1971 • 123 citations

Book Review: Biochemistry of the Acute Allergic Reactions

1969 • 118 citations

Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis.

1969 • 116 citations

Properties of irin, a physiological constituent of the rabbit's iris

1957 • 115 citations

The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs

1972 • 113 citations

Influence of prostaglandin E1 on the terminal vascular bed

1969 • 112 citations

The release of spasmogenic substances from human chopped lung tissue and its inhibition

1973 • 111 citations

Isolation of a chemical trigger for thrombosis

1974 • 103 citations

Efflux of Prostaglandins in Lymph from Scalded Tissue

1971 • 102 citations

Nociceptive Response to Prostaglandins and Analgesic Actions of Aspirin and Morphine

1972 • 100 citations

Cutaneous vascular reactions to prostaglandins in healthy subjects and in

1969 • 95 citations

NARCOTIC AND NON-NARCOTIC ANALGESICS WHICH BLOCK VISCERAL PAIN EVOKED BY INTRA-ARTERIAL INJECTION OF BRADYKININ AND OTHER ALGESIC AGENTS.

1964 • 93 citations

Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold

1973 • 85 citations

Immunochemical and biologic properties of rat IgE. II. Capacity to mediate the immunologic releas of histamine an slow-reacting substance of anaphylaxis (SRS-A).

1970 • 84 citations

Release of histamine, kinin and prostaglandins during carrageenin-induced inflammation in the rat.

1969 • 83 citations

Inhibition of Prostaglandin Biosynthesis by Corticosteroids

1972 • 81 citations

Prostaglandins and the Aspirin-Like Drugs

1972 • 81 citations

A pharmacological analysis of aspirin.

1969 • 74 citations

Prostaglandins and anti-inflammatory drugs in the dog knee joint

1972 • 74 citations

Multiple sites of interaction between prostaglandins and non-steroidal anti-inflammatory agents

1975 • 73 citations

Some Biochemical and Pharmacological Properties of Anti-Inflammatory Drugs

1965 • 69 citations

Uncoupling of Oxidative Phosphorylation by some Arylacetic Acids (Anti-inflammatory or Hypocholesterolemic Drugs)

1964 • 67 citations

A Pharmacological Analysis of Aspirin

1970 • 65 citations

Immunochemical and biologic properties of rat IgE. 3. Modulation of the IgE-mediated release of slow-reacting substance of anaphylaxis by agents influencing the level of cyclic 3',5'-adenosine monoposphate.

1970 • 63 citations

The effects of antiinflammatory drugs on the production of prostaglandins in vivo.

1976 • 60 citations

Efficacy and tolerance of intravenous prostaglandins F2α and E2

1971 • 59 citations

Leukocytes and prostaglandins in acute inflammation

1974 • 47 citations

Further experiments to establish that the analgesic action of aspirin-like drugs depends on the inhibition of prostaglandin biosynthesis.

1973 • 46 citations

The effects of acetaminophen and sodium salicylate on the release and activity of leukocytic pyrogen in the cat.

1972 • 46 citations

THE EFFECT OF ANTI‐INFLAMMATORY DRUGS ON VASCULAR SMOOTH MUSCLE

1967 • 43 citations

Antiarthritic and Antiinflammatory Effects of Certain Prostaglandins

1972 • 42 citations

Novel transformations of prostaglandin endoperoxides: formation of thromboxanes.

1976 • 36 citations

Immunochemical and Biologic Properties of Rat IgE

1970 • 36 citations

Interference of some thiol derivatives with the pharmacological effects of arachidonic acid and Slow Reacting Substance C amd with the release of Rabbit Aorta Contracting substances

1972 • 32 citations

Kinins and Prostaglandins

1971 • 30 citations

Influence of prostaglandins (PG) E2 and F2α on the inflammatory process

1973 • 27 citations

Pro-Inflammatory Effects of Certain Prostaglandins

1972 • 26 citations

Advanced Medicine. Topics in Therapeutics. 1

1976 • 23 citations

The response of normal and asthmatic subjects to prostaglandins E2 and F2alpha by different routes, and their significance in asthma.

1976 • 23 citations

International conference on prostaglandins

1974 • 22 citations

The effect of indomethacin on the tracheal smooth muscle of the guinea-pig.

1972 • 22 citations

Structure-action Relationships among Drugs acting on Connective Tissues (Anti-rheumatic Agents)

1962 • 21 citations

Aspirin

1963 • 20 citations

Aspirin Sensitivity: Other Drugs

1975 • 20 citations

Release of vaso-active substances from lungs by injection of particles.

1970 • 20 citations

(20) Anaphylactoid purpura caused by tartrazine and benzoates

1975 • 18 citations

Anti-Inflammatory Activity of Salicylate

1960 • 17 citations

Anti-Prostaglandin Action of Colchicine

1975 • 17 citations

Aspirin and other cross-reacting small chemicals in known aspirin intolerant patients.

1973 • 17 citations

Transformation of prostaglandin G2 into 6(9)-oxy-11,15-dihydroxy-prosta-7,13-dienoic acid by the rat stomach fundus

1976 • 16 citations

Protein-bound peptides in human serum.

1971 • 10 citations

Platelets, acute inflammation and inflammatory mediators

1976 • 8 citations

Aspirin and exercise-induced asthma

1976 • 7 citations

Factors affecting the microsomal incorporation of amino acids into non-particulate proteins

1962 • 7 citations

The role of prostaglandins in several allergic and inflammatory process.

1974 • 4 citations

Transfer factor in salicylanilide contact allergy.

1973 • 3 citations