Current status of clinical trials of farnesyltransferase inhibitors

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

1999 • 538 citations

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

2001 • 463 citations

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

2001 • 458 citations

THE POTENTIAL OF FARNESYLTRANSFERASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS

1997 • 329 citations

Farnesyl Transferase Inhibitors Block the Farnesylation of CENP-E and CENP-F and Alter the Association of CENP-E with the Microtubules

2000 • 321 citations

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.

1998 • 314 citations

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

2000 • 300 citations

Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer

2000 • 275 citations

Cell Growth Inhibition by Farnesyltransferase Inhibitors Is Mediated by Gain of Geranylgeranylated RhoB

1999 • 255 citations

A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.

2000 • 247 citations

The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis

2000 • 244 citations

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

1998 • 212 citations

Serine/threonine phosphorylation in cytokine signal transduction

2000 • 199 citations

Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia

2001 • 184 citations

Phase I and Pharmacokinetic Study of the Oral Farnesyl Transferase Inhibitor SCH 66336 Given Twice Daily to Patients With Advanced Solid Tumors

2001 • 121 citations

Comparison of potential markers of farnesyltransferase inhibition.

2000 • 121 citations

The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.

1994 • 121 citations

Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336

2001 • 120 citations

Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects

1999 • 116 citations

The farnesyl protein transferase inhibitor SCH66336 synergizes with taxanes in vitro and enhances their antitumor activity in vivo

2000 • 115 citations

The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines

2001 • 112 citations

PxF, a prenylated protein of peroxisomes.

1994 • 107 citations

Farnesyl Protein Transferase Inhibitors and Other Therapies Targeting the Ras Signal Transduction Pathway

1999 • 105 citations

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

1998 • 99 citations

Protein prenylation: from discovery to prospects for cancer treatment

1998 • 79 citations

Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo

1999 • 50 citations

Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors.

1996 • 47 citations

A Mutant Form of Human Protein Farnesyltransferase Exhibits Increased Resistance to Farnesyltransferase Inhibitors

1999 • 42 citations

An antibody which specifically recognizes prelamin A but not mature lamin A: application to detection of blocks in farnesylation-dependent protein processing.

1994 • 38 citations

Drug development train gathering steam

1996 • 19 citations

Protein farnesyl transferase as a target for the development of anticancer drugs

2000 • 16 citations

[5] Assays for inhibitors of CAAX farnesyltransferase in Vitro and in intact cells

1995 • 11 citations