Retrograde axonal transport of neurotrophins: Differences between neuronal populations and implications for motor neuron disease

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

1994 • 804 citations

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1994 • 620 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes

1996 • 434 citations

Neurotrophin-6 is a new member of the nerve growth factor family

1994 • 404 citations

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.

1994 • 397 citations

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

1995 • 381 citations

Muscle-Derived Neurotrophin-4 as an Activity-Dependent Trophic Signal for Adult Motor Neurons

1995 • 377 citations

Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus Heterogeneity

1991 • 373 citations

A diffusible agent of mouse sarcoma, producing hyperplasia of sympathetic ganglia and hyperneurotization of viscera in the chick embryo

1953 • 359 citations

The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organelles.

1980 • 349 citations

Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia

1993 • 323 citations

Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling.

1992 • 321 citations

Neurofilaments and Orthograde Transport Are Reduced in Ventral Root Axons of Transgenic Mice that Express Human SOD1 with a G93A Mutation

1997 • 293 citations

Developmental Neurobiology and the Natural History of Nerve Growth Factor

1982 • 289 citations

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

1993 • 272 citations

Molecular Mechanisms of Axon Growth and Guidance

1991 • 263 citations

Brain dynein (MAP1C) localizes on both anterogradely and retrogradely transported membranous organelles in vivo.

1990 • 261 citations

NGF-stimulated retrograde transport of trkA in the mammalian nervous system.

1995 • 239 citations

Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins

1995 • 217 citations

Actin filaments facilitate two steps of endocytosis

1996 • 187 citations

Motors and membrane traffic

1997 • 187 citations

Immunohistochemical localization of endogenous nerve growth factor

1984 • 178 citations

A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA

1997 • 178 citations

Relation of animal size to convergence, divergence, and neuronal number in peripheral sympathetic pathways

1986 • 133 citations

Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling.

1995 • 131 citations

Neurotrophic Factors Enter the Clinic

1994 • 125 citations

Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero

1992 • 123 citations

Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND

1996 • 118 citations

Neurotrophic Factors and Neuronal Death

2007 • 106 citations

The role of coated vesicles in recycling of synaptic vesicle membrane

1989 • 106 citations

Molecular genetic basis of familial ALS

1996 • 97 citations

Endocytosis and transcytosis

1990 • 93 citations

Sympathetic neurons in neonatal rats require endogenous neurotrophin-3 for survival

1995 • 85 citations

Structure–function relationships in the neurotrophin family

1994 • 81 citations

Localization of neurotrophin-3-like immunoreactivity in peripheral tissues of the rat

1993 • 75 citations

Cell biology of neuronal endocytosis

1993 • 71 citations

Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers

1994 • 65 citations

Cytoplasmic dynein is a vesicle protein.

1992 • 64 citations

In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-βNGF

1997 • 64 citations

Embryonic sensory development: Local expression of neurotrophin‐3 and target expression of nerve growth factor

1994 • 58 citations

Isolation and preliminary characterization of the major membrane boundaries of the endocytic pathway in lymphocytes.

1990 • 56 citations

The role of axonal transport in the regulation of enzyme activity in sympathetic ganglia of adult rats

1979 • 48 citations

Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors

1989 • 41 citations

Neurotropic factors, retrograde axonal transport and cell signalling

1994 • 39 citations

Interaction of Epidermal growth factor receptors with the cytoskeleton is related to receptor clustering

1990 • 36 citations

Axonal transport and targeting of the t-SNAREs SNAP-25 and syntaxin 1 in the peripheral nervous system.

1996 • 33 citations

Duration and magnitude of nerve growth factor signaling depend on the ratio of p75LNTR to TrkA

1998 • 30 citations

Peripheral projections of rat primary sensory neurons immunoreactive for neurotrophin 3

1995 • 29 citations

Dynamics of epidermal growth factor receptor internalization studied by Nanovid light microscopy and electron microscopy in combination with immunogold labeling.

1989 • 20 citations

REGULATION OF ENZYME SYNTHESIS BY NEURONAL ACTIVITY AND BY NERVE GROWTH FACTOR

1974 • 18 citations

Growth and development of sympathetic ganglion: maturation of transmitter enzymes and synapse formation in the mouse superior cervical ganglion.

1971 • 17 citations

Deleted Work

1955 • 0 citations