Stability of K-ras mutations throughout the natural history of human colorectal cancer

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

ras GENES

1987 • 3,818 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

The classification of cancer of the rectum

1932 • 1,529 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies

1990 • 1,037 citations

Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

1988 • 814 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

Allele-specific enzymatic amplification of beta-globin genomic DNA for diagnosis of sickle cell anemia.

1989 • 637 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

1988 • 458 citations

High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.

1989 • 414 citations

A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases

1987 • 413 citations

Clinical perspective of human colorectal cancer metastasis

1984 • 384 citations

A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.

1985 • 320 citations

α1-Antitrypsin deficiency detection by direct analysis of the mutation in the gene

1983 • 277 citations

Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.

1989 • 275 citations

Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridization with sequence-specific oligonucleotides

1987 • 260 citations

RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes.

1987 • 231 citations

Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma.

1989 • 199 citations

Rapid, nonradioactive detection of mutations in the human genome by allele-specific amplification.

1989 • 176 citations

The role of ras and myc oncogenes in human solid tumours and their relevance in diagnosis and prognosis (review).

1990 • 169 citations

Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors.

1987 • 135 citations

Detection of ras point mutations by polymerase chain reaction using mutation-specific, inosine-containing oligonucleotide primers

1989 • 127 citations

Occurrence of Ki-ras and p53 mutations in primary colorectal tumors.

1991 • 72 citations

Correlation of mutations of oncogene C-Ha-ras at codon 12 with metastasis and survival of gastric cancer patients.

1991 • 41 citations

The polymerase chain reaction: A new tool for the detection of minimal residual disease in haematological malignancies

1991 • 37 citations