Adipose Tissue IL-6 Content Correlates with Resistance to Insulin Activation of Glucose Uptake both in Vivo and in Vitro

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

1979 • 7,240 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo¹

1997 • 1,993 citations

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

2001 • 1,843 citations

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

1995 • 1,316 citations

Sleep Apnea and Daytime Sleepiness and Fatigue: Relation to Visceral Obesity, Insulin Resistance, and Hypercytokinemia

2000 • 1,127 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss*

2000 • 1,011 citations

Adipose tissue as an endocrine and paracrine organ

1998 • 1,000 citations

Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

1997 • 919 citations

Circulating Interleukin‐6 in Relation to Adiposity, Insulin Action, and Insulin Secretion

2001 • 637 citations

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

2001 • 577 citations

Circulating Interleukin 6 Levels, Blood Pressure, and Insulin Sensitivity in Apparently Healthy Men and Women

2001 • 549 citations

Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM

1996 • 505 citations

Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes

1997 • 463 citations

Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss

2000 • 444 citations

Molecular mechanisms of insulin resistance and the role of the adipocyte

2000 • 272 citations

In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus.

1983 • 249 citations

Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells

1999 • 170 citations

Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.

1993 • 152 citations

Human Breast Adipocytes Express Interleukin-6 (IL-6) and Its Receptor System: Increased IL-6 Production by β-Adrenergic Activation and Effects of IL-6 on Adipocyte Function

2001 • 151 citations

Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-a gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity

1997 • 100 citations

Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue.

2000 • 91 citations

Subcutaneous adipose tissue expression of tumour necrosis factor‐α is not associated with whole body insulin resistance in obese nondiabetic or in type‐2 diabetic subjects

2000 • 76 citations

Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats

2001 • 75 citations

Hexose transport in human adipocytes: Factors influencing the response to insulin and kinetics of methylglucose and glucose transport

1981 • 55 citations

Percutaneous Adipose Tissue Biopsy by Mini‐Liposuction for Metabolic Studies

1994 • 29 citations

Are free fatty acids related to plasma plasminogen activator inhibitor 1 in android obesity?

1995 • 22 citations

Insulin resistance and noninsulin‐dependent diabetes mellitus: Which horse is pulling the cart?

1989 • 18 citations

Epitope analysis of human IL-6 receptor gp80 molecule with monoclonal antibodies.

1994 • 17 citations