Transcriptional Down-regulation of m2 Muscarinic Receptor Gene Expression in Human Embryonic Lung (HEL 299) Cells by Protein Kinase C

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.

1989 • 627 citations

G protein—coupled receptor kinases

1993 • 434 citations

An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

1987 • 398 citations

Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters

1987 • 379 citations

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.

1989 • 200 citations

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.

1986 • 194 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP.

1990 • 132 citations

Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene.

1988 • 126 citations

Regulation of gene expression by tumor promoters

1990 • 70 citations

Agonist-mediated destabilization of m1 muscarinic acetylcholine receptor mRNA. Elements involved in mRNA stability are localized in the 3'-untranslated region.

1994 • 64 citations

Differential regulation of muscarinic receptor mRNA levels in neuroblastoma cells by chronic agonist exposure: a comparative polymerase chain reaction study.

1993 • 63 citations

Regulation of muscarinic acetylcholine receptor mRNA expression by activation of homologous and heterologous receptors.

1992 • 56 citations

Cloned muscarinic receptor subtypes expressed in A9 L cells differ in their coupling to electrical responses.

1988 • 52 citations

Phosphorylation by Protein Kinase C of the Muscarinic Acetylcholine Receptor

1990 • 47 citations

Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists

1990 • 40 citations

Agonist‐induced down‐regulation of m1 muscarinic receptors and reduction of their mRNA level in a transfected cell line

1990 • 36 citations

Functional effects of protein kinase C-mediated phosphorylation of chick heart muscarinic cholinergic receptors.

1992 • 36 citations

Phosphorylation of muscarinic receptors: regulation by G proteins

1993 • 34 citations

Phosphorylation of the porcine atrial muscarinic acetylcholine receptor by cyclic AMP-dependent protein kinase

1987 • 30 citations

Differential regulation by agonist and phorbol ester of cloned m1 and m2 muscarinic acetylcholine receptors in mouse Y1 adrenal cells and in Y1 cells deficient in cAMP-dependent protein kinase

1990 • 26 citations

Phosphorylation of a phosphoinositidase C‐linked muscarinic receptor by a novel kinase distinct from β‐adrenergic receptor kinase

1993 • 24 citations

Multiple second-messenger pathways mediate agonist regulation of muscarinic receptor mRNA expression

1993 • 23 citations

Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115). Selective loss with subculturing of the low-affinity agonist site mediating cyclic GMP formation.

1984 • 20 citations

Agonist-induced desensitization of cholinergically stimulated phosphoinositide breakdown is independent of endogenously activated protein kinase C in HT-29 human colon carcinoma cells

1990 • 19 citations

Protein kinase regulation of muscarinic receptor signalling in colonic smooth muscle

1993 • 16 citations

Modulation of muscarinic-receptor expression in human embryonic lung fibroblasts by platelet-derived growth factor

1990 • 9 citations

Different regulatory patterns of M1 and M2 muscarinic receptor subtype RNA in SH-SY5Y human neuroblastoma induced by phorbol ester or DMSO

1993 • 8 citations

Endothelin‐1 increases the levels of mRNA and protein of muscarinic acetylcholine receptors and c‐fos mRNA in cerebellar granule cells

1994 • 8 citations