Medroxyprogesterone acetate in the management of cancer cachexia

Cachexia: A new definition

2008 • 2,228 citations

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

2001 • 1,843 citations

Classification and pharmacology of progestins

2003 • 712 citations

Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

2000 • 692 citations

Evidence for the involvement of interleukin 6 in experimental cancer cachexia.

1992 • 648 citations

The role of TNFα in adipocyte metabolism

1999 • 427 citations

Pharmacological profile of progestins

2004 • 360 citations

The syndrome of cardiac cachexia

2002 • 299 citations

Effects of tumour necrosis factor alpha (TNFα) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture

1995 • 265 citations

The metabolic basis of cancer cachexia

1997 • 182 citations

Managing Cancer-Related Anorexia/Cachexia

2001 • 172 citations

Satellite cells express the trophic factor IGF‐I in regenerating skeletal muscle

1987 • 161 citations

Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate.

1998 • 158 citations

A Phase II Study with Antioxidants, Both in the Diet and Supplemented, Pharmaconutritional Support, Progestagen, and Anti-Cyclooxygenase-2 Showing Efficacy and Safety in Patients with Cancer-Related Anorexia/Cachexia and Oxidative Stress

2006 • 156 citations

Binding of progestins to the glucocorticoid receptor

1983 • 154 citations

High-dose progestins for the treatment of cancer anorexia–cachexia syndrome: A systematic review of randomised clinical trials

2001 • 149 citations

Journey from cachexia to obesity by TNF

1997 • 137 citations

Medroxyprogesterone acetate reduces the in vitro production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patients

1997 • 118 citations

Megestrol acetate stimulates food and water intake in the rat: effects on regional hypothalamic neuropeptide Y concentrations

1994 • 113 citations

Effects of medroxyprogesterone acetate on food intake, body composition, and resting energy expenditure in patients with advanced, nonhormone-sensitive cancer

1998 • 109 citations

Cytokine Involvement in Cancer Anorexia/ Cachexia: Role of Megestrol Acetate and Medroxyprogesterone Acetate on Cytokine Downregulation and Improvement of Clinical Symptoms

1998 • 109 citations

A Review of the Drug Treatment of Cachexia Associated with Cancer

1998 • 101 citations

Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results

2008 • 97 citations

Cytokines and Their Role in the Pathophysiology of Cancer Cachexia

1992 • 95 citations

Cytokine‐Induced Anorexia: Behavioral, Cellular, and Molecular Mechanisms^a

1998 • 92 citations

Megestrol acetate in neoplastic anorexia/cachexia: clinical evaluation and comparison with cytokine levels in patients with head and neck carcinoma treated with neoadjuvant chemotherapy

1995 • 77 citations

Novel approaches to the treatment of cachexia

2007 • 74 citations

Effects of celecoxib, medroxyprogesterone, and dietary intervention on systemic syndromes in patients with advanced lung adenocarcinoma: a pilot study

2004 • 71 citations

A double blind placebo controlled trial of medroxyprogesterone acetate (MPA) in cancer cachexia

1993 • 69 citations

Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog

1996 • 65 citations

The Science of Megestrol Acetate Delivery

2005 • 62 citations

Anabolic treatment with GH, IGF-I, or anabolic steroids in patients with HIV-associated wasting

2002 • 55 citations

"Controversial Issues in Climacteric Medicine" Series 3rd Pisa Workshop “HRT in Climacteric and Aging Brain” Under the Auspices of the International Menopause Society, Pisa, Italy, 15–18 March 2003

2003 • 53 citations

Neurochemical mechanisms for cancer anorexia

2002 • 52 citations

Inhibition of experimental cancer cachexia by anti-cytokine and anti-cytokine-receptor therapy.

1995 • 50 citations

Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells

2004 • 49 citations

Pharmacologic management of anorexia/cachexia.

1998 • 45 citations

Insulin-like growth factor I preserves host lean tissue mass in cancer cachexia

1992 • 45 citations

Pharmacologic Doses of Medroxyprogesterone May Cause Bone Loss Through Glucocorticoid Activity: An Hypothesis

2002 • 39 citations

Medroxyprogesterone acetate inhibits interleukin 6 secretion from KPL-4 human breast cancer cells both in vitro and in vivo: a possible mechanism of the anticachectic effect

1999 • 36 citations

Nutritional support and cancer cachexia. Evolving concepts of mechanisms and adjunctive therapies.

1991 • 35 citations

Effect of medroxyprogesterone acetate on the quality of life of the oncologic patient

1997 • 32 citations

Nutritional Support and Cancer Cachexia

1991 • 28 citations

Inhibition of Tumor Progression and Paraneoplastic Syndrome Development in a Murine Lung Adenocarcinoma by Medroxyprogesterone Acetate and Indomethacin

2006 • 26 citations

Comparison of chemotherapy with or without medroxyprogesterone acetate for advanced or recurrent breast cancer

1994 • 21 citations

Retracted: Effect of progestins with different glucocorticoid activity on bone metabolism

2007 • 16 citations

Tumor-associated lymphocytes (TAL) are competent to produce higher levels of cytokines in neoplastic pleural and peritoneal effusions than those found in sera and are able to release into culture higher levels of IL-2 and IL-6 than those released by PBMC

1995 • 15 citations

LACK OF CORRELATION BETWEEN DEFECTIVE CELL-MEDIATED-IMMUNITY AND LEVELS OF SECRETED OR CIRCULATING CYTOKINES IN A STUDY OF 90 CANCER-PATIENTS

1994 • 13 citations

Medroxyprogesterone acetate and cancer cachexia: Interleukin-6 involvement

2000 • 10 citations

The Current Management of Cancer Cachexia

2007 • 4 citations