Novel approaches to the treatment of cachexia

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

2001 • 3,292 citations

Heart-Lung Transplantation

2016 • 2,165 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.

1991 • 1,209 citations

Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study

2003 • 704 citations

Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial

2003 • 590 citations

Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF‐κB‐independent, FoxO1‐dependent mechanism

2006 • 455 citations

THE IMMEDIATE CAUSES OF DEATH IN CANCER

1932 • 418 citations

Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group

2006 • 388 citations

The Influence of Thalidomide on the Clinical and Immunologic Manifestation of Erythema Nodosum Leprosum

1993 • 379 citations

Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial

2005 • 312 citations

The syndrome of cardiac cachexia

2002 • 299 citations

Double-Blind, Placebo-Controlled, Randomized Study of Eicosapentaenoic Acid Diester in Patients With Cancer Cachexia

2006 • 277 citations

Cannabinoids ablate release of TNFα in rat microglial cells stimulated with lypopolysaccharide

2002 • 270 citations

Interleukin-15: a novel anabolic cytokine for skeletal muscle.

1995 • 259 citations

Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia

2007 • 257 citations

A controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advanced cancer

1990 • 238 citations

Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia.

1993 • 227 citations

Effects of Dietary Omega-3 Fatty Acids on Human Breast Cancer Growth and Metastases in Nude Mice

1993 • 224 citations

Effect of ω-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer

1992 • 205 citations

Δ9 Tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells

1998 • 186 citations

The metabolic basis of cancer cachexia

1997 • 182 citations

Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control

2001 • 174 citations

Pharmacological Agents Affecting Emesis

1992 • 171 citations

Assessment of Tumor Necrosis Factor Alpha Blockade As an Intervention to Improve Tolerability of Dose-Intensive Chemotherapy in Cancer Patients

2006 • 168 citations

Anticachectic Effects of Formoterol

2004 • 159 citations

A Phase II Study with Antioxidants, Both in the Diet and Supplemented, Pharmaconutritional Support, Progestagen, and Anti-Cyclooxygenase-2 Showing Efficacy and Safety in Patients with Cancer-Related Anorexia/Cachexia and Oxidative Stress

2006 • 156 citations

Angiotensin II directly induces muscle protein catabolism through the ubiquitin–proteasome proteolytic pathway and may play a role in cancer cachexia

2005 • 136 citations

Metabolic Effects of Tumour Necrosis Factor-α (Cachectin) and Interleukin-1

1989 • 121 citations

Medroxyprogesterone acetate reduces the in vitro production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patients

1997 • 118 citations

Fish Oils Produce Anti-inflammatory Effects and Improve Body Weight in Severe Heart Failure

2006 • 117 citations

Megestrol acetate stimulates food and water intake in the rat: effects on regional hypothalamic neuropeptide Y concentrations

1994 • 113 citations

Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro

1991 • 110 citations

Interleukin‐15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour‐bearing rats

2004 • 104 citations

Body composition changes in patients with systolic heart failure treated with beta blockers: A pilot study

2005 • 92 citations

Cachexia: a therapeutic approach beyond cytokine antagonism

2002 • 88 citations

Interleukin-15 decreases proteolysis in skeletal muscle: A direct effect

2005 • 79 citations

Ghrelin, a Novel Growth Hormonereleasing Peptide, in the Treatment of Cardiopulmonaryassociated Cachexia

2006 • 71 citations

A Randomized, Placebo-Controlled Trial of Nandrolone Decanoate in Human Immunodeficiency Virus-Infected Men with Mild to Moderate Weight Loss with Recombinant Human Growth Hormone as Active Reference Treatment

2005 • 59 citations

Mechanism of lipid mobilization associated with cancer cachexia: Interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein

1993 • 57 citations

Therapy insight: use of melanocortin antagonists in the treatment of cachexia in chronic disease

2006 • 56 citations

Anabolic treatment with GH, IGF-I, or anabolic steroids in patients with HIV-associated wasting

2002 • 55 citations

A phase II randomized, placebo-controlled, double-blind study of the efficacy and safety of RC-1291 (RC) for the treatment of cancer cachexia

2007 • 52 citations

The effects of enalapril‐digoxin‐diuretic combination therapy on nutritional and anthropometric indices in chronic congestive heart failure: preliminary findings in cardiac cachexia

2001 • 44 citations

The Pharmacological Treatment of Cachexia

2004 • 44 citations

Effects of Recombinant Erythropoietin in Palliative Treatment of Unselected Cancer Patients

2004 • 41 citations

Erythropoietin attenuates cachectic events and decreases production of interleukin-6, a cachexia-inducing cytokine

2005 • 35 citations

Palliative treatment of cancer anorexia with oral suspension of megestrol acetate.

2003 • 35 citations

Effect of medroxyprogesterone acetate on the quality of life of the oncologic patient

1997 • 32 citations

The use of melanocortin antagonists in cachexia of chronic disease

2005 • 31 citations

Captopril inhibits the production of tumor necrosis factor-α by human mononuclear cells in patients with congestive heart failure

2001 • 26 citations

Ostarine increases lean body mass and improves physical performance in healthy elderly subjects: Implications for cancer cachexia patients

2007 • 20 citations

Effect of FR143430, a novel cytokine suppressive agent, on adenocarcinoma colon26-induced cachexia in mice.

1998 • 20 citations

Discovery of Corticotropin Releasing Factor 2 Receptor Selective Sauvagine Analogues for Treatment of Skeletal Muscle Atrophy

2004 • 14 citations

Thalidomide and cancer cachexia: old problem, new hope?

2005 • 12 citations