Predicting de novo the folded structure of proteins

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Dominant forces in protein folding

1990 • 3,682 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

THE KINETICS OF FORMATION OF NATIVE RIBONUCLEASE DURING OXIDATION OF THE REDUCED POLYPEPTIDE CHAIN

1961 • 1,148 citations

Knowledge-based prediction of protein structures and the design of novel molecules

1987 • 653 citations

ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

1986 • 538 citations

Modern metabolism as a palimpsest of the RNA world.

1989 • 472 citations

Relative helix-forming tendencies of nonpolar amino acids

1990 • 455 citations

Prediction of protein secondary structure and active sites using the alignment of homologous sequences

1987 • 449 citations

De Novo Design, Expression, and Characterization of Felix: a Four-Helix Bundle Protein of Native-Like Sequence

1990 • 392 citations

The evolution of α/β barrel enzymes

1990 • 378 citations

Alternative packing arrangements in the hydrophobic core of λrepresser

1989 • 375 citations

Structural principles of the globular organization of protein chains. A stereochemical theory of globular protein secondary structure

1974 • 355 citations

cAMP-dependent Protein Kinase

1989 • 274 citations

Analysis of Conformations of Amino Acid Residues and Prediction of Backbone Topography in Proteins

1974 • 236 citations

Design and Synthesis of a Peptide Having Chymotrypsin-Like Esterase Activity

1990 • 215 citations

Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling

1987 • 196 citations

Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase.

1981 • 188 citations

Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate-dependent protein kinase

1983 • 185 citations

THE DEPENDENCE OF THE CONFORMATIONS OF SYNTHETIC POLYPEPTIDES ON AMINO ACID COMPOSITION^1,2

1960 • 180 citations

Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: A prediction of the structure of the catalytic domain of protein kinases

1991 • 173 citations

The design, synthesis, and crystallization of an alpha‐helical peptide

1986 • 135 citations

A search for the most stable folds of protein chains

1991 • 135 citations

Prediction of secondary structure by evolutionary comparison: Application to the α subunit of tryptophan synthase

1987 • 134 citations

Analysis of side-chain orientations in homologous proteins

1987 • 131 citations

Crystal Structure of α₁: Implications for Protein Design

1990 • 126 citations

Modelling the ATP‐binding site of oncogene products, the epidermal growth factor receptor and related proteins

1984 • 121 citations

Mechanistic Studies of cAMP-Dependent Protein Kinase Action

1984 • 108 citations

Design, synthesis and characterisation of a 34-residue polypeptide that interacts with nucleic acids

1979 • 103 citations

Enzyme kinetics and molecular evolution

1989 • 95 citations

Synthesis, purification and initial structural characterization of octarellin, a de novo polypeptide modelled on the α/β-barrel Proteins

1990 • 85 citations

The Evolution of Dehydrogenases and Kinase

1975 • 76 citations

Prediction of progress at last

1991 • 75 citations

Patterns of divergence in homologous proteins as indicators of tertiary and quaternary structure

1989 • 69 citations

Optimizing protein folding to the native state in bacteria

1991 • 60 citations

Interpreting the Behavior of Enzymes Purpose or Pedigree?

1988 • 50 citations

Experimental and theoretical studies of the three‐dimensional structure of human interleukin‐4

1991 • 36 citations

Crystallization studies of cAMP-dependent protein kinase

1985 • 32 citations

Improving the prediction of secondary structure of ‘TIM-barrel’ enzymes

1991 • 32 citations

cAMP-dependent Protein Kinase: A Framework for a Diverse Family of Enzymes

1988 • 31 citations

Computational biochemistry research at ETH

1991 • 28 citations

The design of syntetic genes

1988 • 14 citations

Reconstructing the Evolution of Proteins

1988 • 10 citations

Passing the first milestone in protein design

1988 • 8 citations

Prediction of surface loops of protein-folds from multiple alignments of homologous sequences.

1989 • 5 citations

Designed enzymes: new peptides that fold in aqueous solution and catalyze reactions

1990 • 4 citations

The Design of Peptides and Proteins Ranging from Hormones to Enzymes

1988 • 3 citations

Three-Dimensional Protein Structure Prediction Workshop: Overview and Summary

1990 • 2 citations