Modern metabolism as a palimpsest of the RNA world.

The origin of the genetic code

1968 • 2,226 citations

Evolution of the genetic apparatus

1968 • 962 citations

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

1981 • 877 citations

Coenzymes as fossils of an earlier metabolic state

1976 • 485 citations

tRNA-like structures tag the 3' ends of genomic RNA molecules for replication: implications for the origin of protein synthesis.

1987 • 331 citations

Speculations on the early course of evolution.

1986 • 284 citations

RNA catalysis and the origins of life

1986 • 247 citations

tRNAGlu as a cofactor in δ-aminolevulinate biosynthesis: steps that regulate chlorophyll synthesis

1988 • 172 citations

Cross-species gene transfer; implications for a new theory of evolution

1985 • 148 citations

Phylogenetic evidence for the acquisition of ribosomal RNA introns subsequent to the divergence of some of the major Tetrahymena groups.

1986 • 136 citations

δ-Aminolevulinic Acid-Synthesizing Enzymes Need an RNA Moiety for Activity

1984 • 113 citations

The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans.

1984 • 111 citations

Novel reactions of RNAase P with a tRNA-like structure in turnip yellow mosaic virus RNA

1988 • 110 citations

The origins of the genetic code

1973 • 83 citations

Phosphoenolpyruvic Carboxytransphosphorylase, a CO2 Fixation Enzyme from Propionic Acid Bacteria

1962 • 82 citations

Structure of the Bradyrhizobium japonicum gene hemA encoding 5-aminolevulinic acid synthase

1987 • 81 citations

Location of the redox-active thiols of ribonucleotide reductase: sequence similarity between the Escherichia coli and Lactobacillus leichmannii enzymes

1987 • 75 citations

Natural Selection, Protein Engineering, and the Last Riboorganism: Rational Model Building in Biochemistry

1987 • 70 citations

Biotin. Its place in evolution

1978 • 68 citations

The Pyridine Nucleotide Coenzymes

1983 • 58 citations

A novel hopanoid, 30-(5'-adenosyl)hopane, from the purple non-sulphur bacterium Rhodopseudomonas acidophila, with possible DNA interactions

1985 • 52 citations

Small RNAs in the prokaryotes: A growing list of diverse roles

1988 • 52 citations

Interpreting the Behavior of Enzymes Purpose or Pedigree?

1988 • 50 citations

Inhibition of Fatty Acid Synthetase in Halobacterium cutirubrum and Escherichia coli by High Salt Concentrations

1971 • 47 citations

Eukaryotic nuclear telomeres: Molecular fossils of the RNP world?

1988 • 46 citations

The Mechanism of Action of Aldolases

1965 • 45 citations

Yeast RNase P: catalytic activity and substrate binding are separate functions.

1988 • 43 citations

Redesigning the Molecules of Life

1988 • 34 citations

δ-Aminolevulinic acid synthase of Rhodopseudomonas spheroides

1978 • 32 citations

RNA Catalysis Gives Fresh Perspective on the Origin of Life

1986 • 28 citations

Synthesis of deoxyribomononucleotides in Mollicutes: dependence on deoxyribose-1-phosphate and PPi

1987 • 26 citations

Historical Linguistics

1994 • 21 citations

The regiochemistry and stereochemistry of the biosynthesis of vitamin B6 from triose units.

1987 • 21 citations

Fish to Bacterium Gene Transfer

1985 • 16 citations

Elucidation of methanogenesis seems well on its way

1988 • 16 citations

Mechanism of ribonucleotide reductase from herpes simplex virus type 1. Evidence for 3' carbon-hydrogen bond cleavage and inactivation by nucleotide analogs.

1986 • 14 citations

Return of the 'last ribo-organism'

1988 • 11 citations

Evolution of biocatalysis 1. Possible pre-genetic-code RNA catalysts which are their own replicase

1984 • 10 citations

Biosynthesis of vitamin B-12 Part I. Role of the ribosomal proteins in vitamin B-12 biosynthesis

1981 • 4 citations