Sodium Currents in Medullary Neurons Isolated from the Pre-Bötzinger Complex Region

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Exploratory Data Analysis

1977 • 12,265 citations

Pre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in Mammals

1991 • 2,094 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

[6] Correction for liquid junction potentials in patch clamp experiments

1992 • 1,148 citations

B<scp>REATHING</scp>: Rhythmicity, Plasticity, Chemosensitivity

2003 • 838 citations

Resurgence of Sodium Channel Research

2001 • 672 citations

Lidocaine block of cardiac sodium channels.

1983 • 660 citations

Modulation of Respiratory Frequency by Peptidergic Input to Rhythmogenic Neurons in the PreBötzinger Complex

1999 • 610 citations

Subthreshold Na+-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer II

1989 • 571 citations

Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons

1997 • 571 citations

PREBÖTZINGER COMPLEX AND PACEMAKER NEURONS: Hypothesized Site and Kernel for Respiratory Rhythm Generation

1998 • 569 citations

Models of Respiratory Rhythm Generation in the Pre-Bötzinger Complex. I. Bursting Pacemaker Neurons

1999 • 538 citations

Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons

2001 • 529 citations

Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons

1995 • 451 citations

Neuronal pacemaker for breathing visualized in vitro

1999 • 442 citations

Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice

1997 • 401 citations

Riluzole inhibits the persistent sodium current in mammalian CNS neurons

2000 • 384 citations

A voltage-dependent persistent sodium current in mammalian hippocampal neurons.

1990 • 377 citations

Models of Respiratory Rhythm Generation in the Pre-Bötzinger Complex. II. Populations of Coupled Pacemaker Neurons

1999 • 371 citations

Intrinsic Membrane Properties Underlying Spontaneous Tonic Firing in Neostriatal Cholinergic Interneurons

2000 • 325 citations

Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons

1995 • 312 citations

Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex

1993 • 303 citations

Subthreshold Sodium Current from Rapidly Inactivating Sodium Channels Drives Spontaneous Firing of Tuberomammillary Neurons

2002 • 302 citations

Sodium and Calcium Current-Mediated Pacemaker Neurons and Respiratory Rhythm Generation

2005 • 292 citations

Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component

1988 • 289 citations

Adjustable Amplification of Synaptic Input in the Dendrites of Spinal Motoneurons In Vivo

2000 • 287 citations

Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker–network model

2000 • 275 citations

Subthreshold Sodium Currents and Pacemaking of Subthalamic Neurons

2003 • 270 citations

Persistent Sodium Current, Membrane Properties and Bursting Behavior of Pre-Bötzinger Complex Inspiratory Neurons In Vitro

2002 • 261 citations

Functional Analysis of the Mouse Scn8a Sodium Channel

1998 • 255 citations

Ionic Currents and Spontaneous Firing in Neurons Isolated from the Cerebellar Nuclei

2000 • 243 citations

Respiratory Rhythm

2002 • 241 citations

Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons

2000 • 236 citations

Action potential threshold of hippocampal pyramidal cells in vivo is increased by recent spiking activity

2001 • 231 citations

Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre

1991 • 219 citations

D₁/D₅Dopamine Receptor Activation Differentially Modulates Rapidly Inactivating and Persistent Sodium Currents in Prefrontal Cortex Pyramidal Neurons

2001 • 217 citations

Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons.

1994 • 201 citations

Selective lesioning of the cat pre‐Bötzinger complex in vivo eliminates breathing but not gasping

1998 • 193 citations

Pacemaker behavior of respiratory neurons in medullary slices from neonatal rat

1994 • 189 citations

Identification of Two Types of Inspiratory Pacemaker Neurons in the Isolated Respiratory Neural Network of Mice

2001 • 186 citations

Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole.

1994 • 185 citations

Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.

1997 • 171 citations

Transmitter Modulation of Slow, Activity-Dependent Alterations in Sodium Channel Availability Endows Neurons with a Novel Form of Cellular Plasticity

2003 • 163 citations

Biophysical Properties and Slow Voltage-Dependent Inactivation of a Sustained Sodium Current in Entorhinal Cortex Layer-II Principal Neurons

1999 • 159 citations

Serotonin Receptor Activation Inhibits Sodium Current and Dendritic Excitability in Prefrontal Cortex via a Protein Kinase C-Dependent Mechanism

2002 • 157 citations

Kinetic and Stochastic Properties of a Persistent Sodium Current in Mature Guinea Pig Cerebellar Purkinje Cells

1998 • 146 citations

Kinetics of slow inactivation of persistent sodium current in layer V neurons of mouse neocortical slices

1996 • 134 citations

Sodium Current in Rat and Cat Thalamocortical Neurons: Role of a Non-Inactivating Component in Tonic and Burst Firing

1998 • 131 citations

Fluro-Gold: composition, and mechanism of uptake

1991 • 123 citations

Characterizations of eupnea, apneusis and gasping in a perfused rat preparation

2000 • 111 citations

The sodium current underlying action potentials in guinea pig hippocampal CA1 neurons.

1988 • 108 citations

Resurgent Na Currents in Four Classes of Neurons of the Cerebellum

2004 • 107 citations

Ionic Mechanisms of Intrinsic Oscillations in Neurons of the Basolateral Amygdaloid Complex

1998 • 104 citations

Patterns of Phrenic Motor Output Evoked by Chemical Stimulation of Neurons Located in the Pre-Bötzinger Complex In Vivo

1999 • 94 citations

Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells

1997 • 93 citations

Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat.

2002 • 89 citations

Defining ventral medullary respiratory compartments with a glutamate receptor agonist in the rat

2003 • 89 citations

Depressor and Tachypneic Responses to Chemical Stimulation of the Ventral Respiratory Group Are Reduced by Ablation of Neurokinin-1 Receptor-Expressing Neurons

2002 • 88 citations

Sodium channel internalization in developing neurons

1994 • 61 citations

Sodium Currents in Neurons From the Rostroventrolateral Medulla of the Rat

2003 • 60 citations

Neural Control of Breathing

2005 • 55 citations

Fluoro-Gold injected either subcutaneously or intravascularly results in extensive retrograde labelling of CNS neurones having axons terminating outside the blood-brain barrier

1989 • 52 citations

The cardiac sodium channel mRNA is expressed in the developing and adult rat and human brain

2000 • 52 citations

Neurogenesis of gasping does not require inhibitory transmission using GABAA or glycine receptors

2002 • 26 citations

Respiratory Rhythm Generation: Prebötzinger Neuron Discharge Patterns and Persistent Sodium Current

2001 • 17 citations