Autoxidation of Amyloid Precursor Protein and Formation of Reactive Oxygen Species

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

Copper biochemistry and molecular biology

1996 • 1,171 citations

Hopes for the Future: Restoration Ecology and Conservation Biology

1997 • 1,006 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

The Copper Chaperone for Superoxide Dismutase

1997 • 828 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Inactivation of the enzyme

1975 • 777 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Metal Ion Chaperone Function of the Soluble Cu(I) Receptor Atx1

1997 • 675 citations

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

1996 • 657 citations

h CTR1 : A human gene for copper uptake identified by complementation in yeast

1997 • 541 citations

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1995 • 493 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

1994 • 393 citations

Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice

1995 • 353 citations

Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae

1997 • 324 citations

A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease

1993 • 289 citations

The βA4 amyloid precursor protein binding to copper

1994 • 244 citations

DOPAMINE BETA-HYDROXYLASE OF ADRENAL CHROMAFFIN GRANULES: STRUCTURE AND FUNCTION

1988 • 240 citations

Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques

1989 • 233 citations

Reactive oxygen species and Alzheimer's disease

1997 • 228 citations

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.

1995 • 212 citations

Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis.

1996 • 209 citations

Alzheimer's Disease: Biology, Diagnosis and Therapeutics

1998 • 201 citations

The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1997 • 179 citations

Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux

1995 • 178 citations

Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I

1996 • 170 citations

Alzheimer's disease : biology, diagnosis, and therapeutics

1996 • 151 citations

A Familial Amyotrophic Lateral Sclerosis-associated A4V Cu,Zn-Superoxide Dismutase Mutant Has a Lower K for Hydrogen Peroxide

1997 • 150 citations

Copper Transport: An Overview

1991 • 146 citations

Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme.

1992 • 134 citations

Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins.

1992 • 128 citations

Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites

1995 • 122 citations

Total Reconstitution of Copper-Zinc Superoxide Dismutase

1974 • 121 citations

Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.

1990 • 114 citations

Proteolytic Processing of Alzheimer's Disease βA4 Amyloid Precursor Protein in Human Platelets

1995 • 105 citations

Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP)

1994 • 89 citations

Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans

1994 • 70 citations

Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants

1994 • 65 citations

Qualitative and Quantitative Differences in Senile Plaque Dystrophie Neurites of Alzheimerʼs Disease and Normal Aged Brain

1995 • 63 citations

Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor.

1992 • 62 citations

APP-collagen interaction is mediated by a heparin bridge mechanism

1992 • 49 citations

Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid β-Protein precursor

1995 • 31 citations

Ascorbate Enhances Copper Transport from Ceruloplasmin into Human K562 Cells

1989 • 28 citations

Purification of factor XIa inhibitor from human platelets

1992 • 20 citations

Alzheimer's Disease: Genesis of Amyloid

2007 • 12 citations

The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc

1997 • 1 citations