Endothelium-Dependent Relaxation in Systemic Arteries

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Calcitonin gene-related peptide is a potent vasodilator

1985 • 2,050 citations

Role of endothelium in responses of vascular smooth muscle.

1983 • 1,975 citations

Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

1985 • 1,266 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs

1984 • 937 citations

Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin

1983 • 855 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs.

1953 • 643 citations

Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

1983 • 623 citations

The nature of endothelium-derived vascular relaxant factor

1984 • 591 citations

Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

1981 • 527 citations

Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin.

1978 • 446 citations

The Pharmacology of Vascular Smooth Muscle

1996 • 435 citations

Role of endothelial cells in relaxation of isolated arteries by bradykinin.

1982 • 420 citations

Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.

1986 • 397 citations

Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor.

1986 • 381 citations

Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.

1981 • 380 citations

Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery.

1982 • 345 citations

Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.

1978 • 327 citations

Endothelial Cells as Mediators of Vasodilation of Arteries

1984 • 322 citations

Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries.

1986 • 295 citations

Vascular neuroeffector Mechanisms

1980 • 279 citations

Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery.

1984 • 257 citations

Vasopressin causes endothelium-dependent relaxations of the canine basilar artery.

1984 • 251 citations

Role of the endothelium in the vasodilator response of rat thoracic aorta to histamine

1983 • 249 citations

The requirement for endothelial cells in the relaxation of arteries by acetylcholine and some other vasodilators

1981 • 231 citations

Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips.

1982 • 228 citations

Acetylcholine and Bradykinin Relax Intrapulmonary Arteries by Acting on Endothelial Cells: Role in Lung Vascular Diseases

1981 • 226 citations

The role of endothelium in the control of vascular tone

1985 • 202 citations

Calcium- and endothelial-mediated vascular smooth muscle relaxation in rabbit aorta.

1982 • 202 citations

A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation

1969 • 197 citations

5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries

1983 • 194 citations

Properties and regulation of guanylate cyclase and some proposed functions for cyclic GMP.

1979 • 187 citations

Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor.

1986 • 167 citations

Endothelium‐dependent relaxation of the pig aorta: relationship to stimulation of ⁸⁶Rb efflux from isolated endothelial cells

1983 • 166 citations

Bioassay of endothelium-derived relaxing factor(s): inactivation by catecholamines

1985 • 154 citations

Mechanisms of vasodilation

1983 • 148 citations

Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous hemoproteins.

1985 • 145 citations

Production of endothelium derived relaxant factor is dependent on oxidative phosphorylation and extracellular calcium

1986 • 143 citations

Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation

1985 • 131 citations

Vascular Neuroeffector Mechanisms

1984 • 125 citations

Endothelium-derived vascular relaxing factor.

1985 • 120 citations

Species-dependent differences in the nature of endothelium-derived vascular relaxing factor

1984 • 114 citations

Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides.

1977 • 110 citations

Inhibition by Acetylcholine of Adrenergic Neurotransmission in Vascular Smooth Muscle

1974 • 110 citations

Endothelium-dependent relaxation of rabbit aorta. I. Relaxation stimulated by arachidonic acid.

1983 • 96 citations

Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery

1984 • 90 citations

Inhibition of adrenergic neurotransmission by parasympathomimetics in the rabbit ear artery.

1973 • 82 citations

Possible role for cyclic GMP in endothelium-dependent relaxation of rabbit aorta by acetylcholine. Comparison with nitroglycerin.

1983 • 74 citations

Block of some non‐adrenergic inhibitory responses of smooth muscle by a substance from haemolysed erythrocytes

1982 • 66 citations

Neurogenic muscarinic vasodilation in the cat. An example of endothelial cell-independent cholinergic relaxation.

1985 • 64 citations

The effects of cholinomimetic drugs on responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery

1970 • 51 citations

Endothelium-dependent vasodilation by melittin: are lipoxygenase products involved?

1985 • 51 citations

Cholinergic inhibition of adrenergic transmission.

1977 • 43 citations

Redox modulation of splenic cell soluble guanylate cyclase activity: activation by hydrophilic and hydrophobic oxidants represented by ascorbic and dehydroascorbic acids, fatty acid hydroperoxides, and prostaglandin endoperoxides.

1978 • 40 citations

Endothelium-dependent responses: the last three years.

1984 • 37 citations

Ergometrine-induced arterial dilatation: An endothelium-mediated effect

1984 • 27 citations

Perspectives on receptor classification

1987 • 26 citations

Effect of acetylcholine on the response of the isolated rabbit ear artery to stimulation of the perivascular sympathetic nerves

1972 • 24 citations

VASODILATOR MECHANISMS

1923 • 19 citations

Comparison of endothelium-dependent relaxation by acetylcholine and endothelium-independent relaxation by light in the rabbit aorta

1984 • 16 citations

Endothelium and relaxation of isolated canine arteries

1980 • 10 citations