Enhanced metabolism of arachidonic acid by macrophages from nonobese diabetic (NOD) mice

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Dietary polyunsaturated fatty acids and eicosanoids: potential effects on the modulation of inflammatory and immune cells: an overview.

1990 • 417 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

1990 • 245 citations

Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study.

1985 • 237 citations

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans.

1988 • 235 citations

Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice

1988 • 232 citations

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1984 • 220 citations

Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice

1987 • 216 citations

Gonadal steroids modulate human monocyte interleukin‐1 (IL‐1) activity

1989 • 186 citations

Oestrogen Receptors in Macrophages

1990 • 183 citations

Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats

1989 • 183 citations

The non-obese diabetic (NOD) mouse.

1987 • 172 citations

Effect of estradiol on interleukin 1 synthesis by macrophages

1988 • 170 citations

Administration of Silica Particles or Anti-Lyt2 Antibody Prevents β-Cell Destruction in NOD Mice Given Cyclophosphamide

1988 • 156 citations

Preventive effects of Cyclosporin on diabetes in NOD mice

1986 • 155 citations

Gonadal steroids modulate human monocyte interleukin-1 (IL-1) activity

1988 • 154 citations

Immunoregulation by leukotrienes and other lipoxygenase metabolites

1985 • 147 citations

The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice

1989 • 146 citations

Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1.

1987 • 145 citations

Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression

1991 • 130 citations

Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.

1988 • 130 citations

Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning

1989 • 122 citations

Eicosanoids and inflammation

1988 • 122 citations

Preferential Infiltration of Macrophages During Early Stages of Insulitis in Diabetes-Prone BB Rats

1988 • 118 citations

Leukotrienes: positive signals for regulation of gamma-interferon production.

1984 • 118 citations

Distinct Macrophage Subpopulations in Pancreas of Prediabetic BB/E Rats: Possible Role for Macrophages in Pathogenesis of IDDM

1988 • 116 citations

Spontaneous cytotoxicity of macrophages against pancreatic islet cells.

1989 • 115 citations

Leukotrienes in inflammation

1986 • 108 citations

Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats

1989 • 105 citations

Leukotrienes and inflammation

1990 • 105 citations

Phospholipase A2 activity in the rat uterus: Modulation by steroid hormones

1982 • 104 citations

<b>The inhibitory effect of neonatal thymectomy on the incidence of insulitis in non-obese diabetes (NOD) </b><b>mice </b>

1985 • 103 citations

Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice

1987 • 96 citations

Anti‐α/β T cell receptor monoclonal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic (NOD) mice

1991 • 89 citations

Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1

1988 • 79 citations

Lessons from the NOD mouse for the pathogenesis and immunotherapy of human Type 1 (insulin-dependent) diabetes mellitus

1989 • 78 citations

Biochemistry of macrophages.

1986 • 77 citations

The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young males

1990 • 76 citations

Non-obese-diabetic mice: immune mechanisms of pancreatic ?-cell destruction

1984 • 76 citations

Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages.

1984 • 73 citations

Evidence for initial involvement of macrophage in development of insulitis in NOD mice

1988 • 70 citations

Mechanisms of autoimmunity in insulin-dependent diabetes mellitus.

1988 • 64 citations

Administration of silica particles or anti-Lyt2 antibody prevents beta-cell destruction in NOD mice given cyclophosphamide

1988 • 61 citations

Functional Characteristics of Rat Pancreatic Islets Maintained in Culture After Exposure to Human Interleukin 1

1988 • 60 citations

Thromboxane synthase is preferentially conserved in activated mouse peritoneal macrophages.

1985 • 57 citations

Possible role of IL-1, TNF-alpha, and IL-6 in insulin-dependent diabetes mellitus and autoimmune thyroid disease. Thyroid Cell Group.

1989 • 56 citations

Expression of Ia and the production of interleukin 1 by peritoneal exudate macrophages activated by steroids

1986 • 53 citations

Administration of silica or monoclonal antibody to Thy-1 prevents low-dose streptozotocin-induced diabetes in mice

1986 • 51 citations

Prostaglandin production by phagocytic cells of the mouse thymic reticulum in culture and its modulation by indomethacin and corticosteroids.

1985 • 48 citations

Immunomodulation by eicosanoids and anti-inflammatory drugs

1989 • 46 citations

In situ analysis of pancreatic islets in rats developing diabetes. Appearance of nonendocrine cells with surface MHC class II antigens and cytoplasmic insulin immunoreactivity.

1988 • 45 citations

Lipoxygenase pathways of macrophages.

1985 • 44 citations

Studies on Autoimmunity for Initiation of β-Cell Destruction: VI. Macrophages Essential for Development of β-Cell–Specific Cytotoxic Effectors and Insulitis in NOD Mice

1990 • 43 citations

Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats

1989 • 40 citations

Interleukin 6: A Functional and Structuralin VitroModulator of Beta-Cells from Islets of Langerhans

1990 • 39 citations

Distinct macrophage subpopulations in pancreas of prediabetic BB/E rats. Possible role for macrophages in pathogenesis of IDDM

1988 • 39 citations

EFFECTS OF PROSTAGLANDINS E₂ AND I₂ ON HUMAN LYMPHOCYTE TRANSFORMATION IN THE PRESENCE AND ABSENCE OF INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS

1979 • 36 citations

Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats

1988 • 35 citations

Cytokines and eicosanoids in rheumatic diseases.

1990 • 33 citations

Effect of exogenous prostaglandins and nonsteroidal anti-inflammatory agents on prostaglandin secretion and proliferation of mouse embryo fibroblasts in culture

1989 • 32 citations

The effect of estradiol on human myelomonocytic cells. 1. Enhancement of colony formation

1985 • 31 citations

Presence of Pancreatic Hormones in Islet Cells With MHC-Class II Antigen Expression

1987 • 30 citations

Studies on Autoimmunity For Initiation of β-Cell Destruction: V. Decrease of Macrophage-Dependent T Lymphocytes and Natural Killer Cytotoxicity in Silica-Treated BB Rats

1990 • 30 citations

Macrophage-Mediated Islet Cell Cytotoxicity in BB Rats

1989 • 24 citations

Aberrant production of leukotriene C4 by macrophages from autoimmune-prone mice.

1988 • 24 citations

THE INFLUENCE OF THE ESTRUS CYCLE, PREGNANCY AND OVARIECTOMY ON RES ACTIVITY.

1965 • 23 citations

Thromboxane and Prostacyclin in Disease: a Review

1983 • 22 citations

Prostacyclin biosynthesis in activated, stimulated and normal mouse peritoneal cell populations

1978 • 21 citations

Gender differences in eicosanoid production from macrophages of arthritis-susceptible mice.

1987 • 20 citations

Dual effects of cyclosporine a on arachidonate metabolism by peritoneal macrophages

1989 • 18 citations

Studies on autoimmunity for initiation of beta-cell destruction. VI. Macrophages essential for development of beta-cell-specific cytotoxic effectors and insulitis in NOD mice

1990 • 17 citations

The effect of estradiol on human myelomonocytic cells

1986 • 17 citations

Effects of a stable prostacyclin analogue on platelet activity and on host immunocompetence in mice

1990 • 14 citations

Suppression of concanavalin A-induced responses in splenic lymphocytes by activated macrophages in the non-obese diabetic mouse

1989 • 14 citations

Interleukin 1 and/or tumor necrosis factor-α synergize with granulocyte-macrophage colony-stimulating factor to enhance histamine synthesis in hematopoietic cells: role of prostaglandin e2

1989 • 14 citations

Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1

1988 • 13 citations

Mononuclear phagocytes, prostanoids and rheumatoid arthritis

1982 • 12 citations

Presence of pancreatic hormones in islet cells with MHC-class II antigen expression

1987 • 11 citations

Synthesis of prostaglandin E by peritoneal macrophages from NZB/W mice

1988 • 10 citations

Studies on autoimmunity for initiation of beta-cell destruction. V. Decrease of macrophage-dependent T lymphocytes and natural killer cytotoxicity in silica-treated BB rats

1990 • 10 citations

Bioconversion of leukotriene C4 by rat glomeruli and papilla

1986 • 10 citations

Macrophage-mediated islet cell cytotoxicity in BB rats

1989 • 9 citations

Structural Basis for Arachidonic Acid Second Messenger Signal in Gamma‐Interferon Inductiona

1988 • 8 citations

Effect of serum on the metabolism of exogenous arachidonic acid by phagocytic cells of the mouse thymic reticulum

1986 • 8 citations

Prostaglandins and leukotrienes

1989 • 8 citations

Phospholipase A2, an in vivo immunomodulator

1990 • 6 citations

Expression of Class II MHC Antigens in Murine Pancreas After Streptozocin-Induced Insulitis

1988 • 6 citations

Eicosanoid release and early changes in two acute non specific inflammatory reactions. Major role of prostacyclin and leukotrienes

1991 • 4 citations

Expression of class II MHC antigens in murine pancreas after streptozocin-induced insulitis

1988 • 2 citations