The general mitochondrial matrix processing protease from rat liver: structural characterization of the catalytic subunit.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Domain structure of mitochondrial and chloroplast targeting peptides

1989 • 1,191 citations

Use of Helical Wheels to Represent the Structures of Proteins and to Identify Segments with Helical Potential

1967 • 1,178 citations

Mitochondrial targeting sequences may form amphiphilic helices.

1986 • 1,019 citations

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

1989 • 933 citations

Mitochondrial protein import

1989 • 820 citations

A one-step purification of membrane proteins using a high efficiency immunomatrix.

1982 • 782 citations

Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins

1987 • 637 citations

Mitochondrial protein import: Identification of processing peptidase and of PEP, a processing enhancing protein

1988 • 388 citations

Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria.

1982 • 351 citations

Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase

1986 • 340 citations

MOM19, an import receptor for mitochondrial precursor proteins

1989 • 334 citations

Generation of cDNA Probes Directed by Amino Acid Sequence: Cloning of Urate Oxidase

1988 • 325 citations

Purification of microsomal signal peptidase as a complex.

1986 • 313 citations

Survey of amino-terminal proteolytic cleavage sites in mitochondrial precursor proteins: leader peptides cleaved by two matrix proteases share a three-amino acid motif.

1989 • 303 citations

Requirement of a Membrane Potential for the Posttranslational Transfer of Proteins into Mitochondsria

1982 • 292 citations

A one-tube plasmid DNA mini-preparation suitable for sequencing

1988 • 278 citations

Nucleotide sequence of the yeast nuclear gene for cytochrome c peroxidase precursor. Functional implications of the pre sequence for protein transport into mitochondria.

1982 • 249 citations

A leader peptide is sufficient to direct mitochondrial import of a chimeric protein.

1985 • 239 citations

Purification and characterization of leader (signal) peptidase from Escherichia coli.

1980 • 237 citations

Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes.

1988 • 219 citations

The imported preprotein of the proteolipid subunit of the mitochondrial ATP synthase from Neurospora crassa. Molecular cloning and sequencing of the mRNA.

1982 • 205 citations

Import of proteins into mitochondria. Partial purification of a matrix-located protease involved in cleavage of mitochondrial precursor polypeptides.

1983 • 201 citations

The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix

1984 • 199 citations

Protein unfolding and the energetics of protein translocation across biological membranes

1988 • 192 citations

The processing peptidase of yeast mitochondria: the two co-operating components MPP and PEP are structurally related.

1988 • 152 citations

Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit.

1988 • 149 citations

Purification and characterization of a processing protease from rat liver mitochondria.

1989 • 134 citations

Two mitochondrial matrix proteases act sequentially in the processing of mammalian matrix enzymes.

1988 • 122 citations

Isolation and characterization of propionyl-CoA carboxylase from normal human liver. Evidence for a protomeric tetramer of nonidentical subunits.

1980 • 111 citations

A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides.

1985 • 107 citations

Statistical analysis of the distribution of amino acid residues among helical and non-helical regions in globular proteins

1969 • 96 citations

Precursor proteins are transported into mitochondria in the absence of proteolytic cleavage of the additional sequences.

1983 • 95 citations

Matrix processing peptidase of mitochondria. Structure-function relationships.

1990 • 85 citations

Energy-dependent translocation of the precursor of ornithine transcarbamylase by isolated rat liver mitochondria.

1982 • 78 citations

Import of rat ornithine transcarbamylase precursor into mitochondria: two-step processing of the leader peptide.

1987 • 76 citations

Mitochondrial import and processing of mutant human ornithine transcarbamylase precursors in cultured cells.

1988 • 26 citations

Mitochondrial Import and Processing of Mutant Human Ornithine Transcarbamylase Precursors in Cultured Cells

1988 • 11 citations