Structure of gap junction intercellular channels

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

The Gap Junction Communication Channel

1996 • 1,896 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling

1996 • 1,301 citations

Junctional intercellular communication: the cell-to-cell membrane channel.

1981 • 1,268 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Connexin43: a protein from rat heart homologous to a gap junction protein from liver.

1987 • 1,111 citations

Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells.

1995 • 821 citations

Molecular cloning of cDNA for rat liver gap junction protein.

1986 • 715 citations

Structure of the junction between communicating cells

1980 • 697 citations

Connexin family of gap junction proteins

1990 • 553 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues.

1989 • 516 citations

Gap junction structures: Analysis of the x-ray diffraction data

1977 • 501 citations

Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein.

1986 • 443 citations

Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA.

1989 • 427 citations

Mutations of theConnexin43Gap-Junction Gene in Patients with Heart Malformations and Defects of Laterality

1995 • 376 citations

Two configurations of a channel-forming membrane protein

1984 • 368 citations

Opposite voltage gating polarities of two closely related onnexins

1994 • 353 citations

Gap junction structures. I. Correlated electron microscopy and x-ray diffraction.

1977 • 341 citations

Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.

1991 • 340 citations

Topology of the 32-kd liver gap junction protein determined by site-directed antibody localizations.

1988 • 327 citations

Structure-activity relations of the cardiac gap junction channel

1990 • 312 citations

Two-dimensional crystallization of membrane proteins

1992 • 292 citations

Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins.

1994 • 286 citations

Characterization of the Mitogen-activated Protein Kinase Phosphorylation Sites on the Connexin-43 Gap Junction Protein

1996 • 282 citations

Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.

1990 • 276 citations

Heteromeric connexons in lens gap junction channels.

1996 • 273 citations

Intramolecular interactions mediate pH regulation of connexin43 channels

1996 • 263 citations

Functional analysis of selective interactions among rodent connexins.

1995 • 256 citations

Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation.

1994 • 254 citations

The diversity of connexin genes encoding gap junctional proteins.

1991 • 230 citations

Molecular biology and genetics of gap junction channels

1992 • 225 citations

The 43-kD polypeptide of heart gap junctions: immunolocalization, topology, and functional domains.

1989 • 224 citations

Topological analysis of the major protein in isolated intact rat liver gap junctions and gap junction-derived single membrane structures.

1987 • 205 citations

New functions for gap junctions

1995 • 203 citations

Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions.

1988 • 199 citations

Gap junction structures

1984 • 193 citations

Phosphorylation of connexin 32, a hepatocyte gap‐junction protein, by cAMP‐dependent protein kinase, protein kinase C and Ca²⁺/calmodulin‐dependent protein kinase II

1990 • 188 citations

A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail length

1993 • 176 citations

Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase.

1993 • 174 citations

The Gap Junction Proteins β1-Connexin (Connexin-32) and β2-Connexin (Connexin-26) Can Form Heteromeric Hemichannels

1995 • 171 citations

Structure of the extracellular surface of the gap junction by atomic force microscopy

1993 • 170 citations

Identification of a proline residue as a transduction element involved in voltage gating of gap junctions

1993 • 160 citations

Functional analysis of human cardiac gap junction channel mutants.

1991 • 160 citations

Biochemical and immunochemical analysis of the arrangement of connexin43 in rat heart gap junction membranes

1990 • 158 citations

Mutational analysis of gap junction formation

1992 • 157 citations

Membrane topology and quaternary structure of cardiac gap junction ion channels

1992 • 150 citations

pp60 -mediated Phosphorylation of Connexin 43, a Gap Junction Protein

1995 • 142 citations

Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos.

1990 • 135 citations

Isolation and purification of gap junction channels.

1991 • 126 citations

Topology of the Mr 27,000 liver gap junction protein. Cytoplasmic localization of amino- and carboxyl termini and a hydrophilic domain which is protease-hypersensitive.

1988 • 119 citations

Conservation of a cytoplasmic carboxy-terminal domain of connexin 43, a gap junctional protein, in mammal heart and brain

1990 • 104 citations

Two forms of isolated gap junctions

1979 • 100 citations

A domain substitution procedure and its use to analyze voltage dependence of homotypic gap junctions formed by connexins 26 and 32.

1992 • 99 citations

Mixing of connexins in gap junction membrane channels.

1995 • 99 citations

Cell/cell channel formation involves disulfide exchange

1991 • 98 citations

Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43.

1994 • 97 citations

Topography of connexin32 in rat liver gap junctions : Evidence for an intramolecular disulphide linkage connecting the two extracellular peptide loops

1991 • 90 citations

Synthesis and assembly of human β1 gap junctions in BHK cells by DNA transfection with the human β1 cDNA

1995 • 88 citations

The topological structure of connexin 26 and its distribution compared to connexin 32 in hepatic gap junctions

1994 • 70 citations

Connexon integrity is maintained by non-covalent bonds: Intramolecular disulfide bonds link the extracellular domains in rat connexin-43

1991 • 60 citations

Dynamics of connexin43 phosphorylation in pp60v-src-transformed cells

1993 • 58 citations

Diffraction diagnosis of protein folding in gap junction connexons

1990 • 48 citations

Gap junction channel modulation—A physiological viewpoint

1986 • 42 citations

In vitro assembly of gap junctions

1991 • 36 citations

The secondary structure of gap junctions. Influence of isolation methods and proteolysis.

1990 • 36 citations

Rat connexin43: regulation by phosphorylation in heart

1993 • 29 citations

In situ two-dimensional crystallization of a polytopic membrane protein: the cardiac gap junction channel

1994 • 13 citations

Electron microscopic image analysis of cardiac gap junction membrane crystals

1995 • 11 citations

Structure and design of cardiac gap-junction membrane channels

1993 • 10 citations

Molecular Biology and Electrophysiology of Cardiac Gap Junctions

1994 • 8 citations