Oxygen supplementation restores theophylline clearance to normal in cirrhotic rats

Relative Importance of Diffusion and Chemical Reaction Rates in Determining Rate of Exchange of Gases in the Human Lung, With Special Reference to True Diffusing Capacity of Pulmonary Membrane and Volume of Blood in the Lung Capillaries

1957 • 983 citations

High Yield Micronodular Cirrhosis in the Rat

1982 • 289 citations

Protein Binding and Kinetics of Drugs in Liver Diseases

1977 • 262 citations

Multivariate Analysis

1988 • 161 citations

Clinical Pharmacokinetics in Patients with Liver Disease

1991 • 147 citations

Determinants of Drug Disposition in Patients with Cirrhosis

1983 • 134 citations

Mechanism for reduced drug clearance in patients with cirrhosis

1978 • 128 citations

Hypoxia and drug metabolism

1981 • 122 citations

Determinants of hepatic function in liver cirrhosis in the rat. Multivariate analysis.

1988 • 97 citations

Changes in regional blood flow distribution and oxygen supply during hypoxia in conscious rats

1993 • 91 citations

Is glucuronidation truly preserved in patients with liver disease?

1991 • 88 citations

Is glucuronidation truly preserved in patients with liver disease?

1991 • 75 citations

The effects of age and chronic liver disease on the elimination of temazepam

1986 • 57 citations

Chronic verapamil administration lowers portal pressure and improves hepatic function in rats with liver cirrhosis

1986 • 55 citations

Dose-dependent elimination of theophylline in rats

1985 • 53 citations

Regional blood flow in conscious resting rats determined by microsphere distribution

1993 • 43 citations

Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple-indicator dilution technique

1993 • 42 citations

Therapeutic implications of impaired hepatic oxygen diffusion in chronic liver disease

1991 • 40 citations

Hepatic arterial and portal venous oxygen content and extraction in liver cirrhosis

1993 • 36 citations

Review article: hypoxia and hepatic drug metabolism—clinical implications

1990 • 29 citations

Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat

1993 • 28 citations

Determinants of Hepatic Function in Liver Cirrhosis in the Rat

1988 • 24 citations

Pharmacokinetic-Hemodynamic Interactions in Cirrhosis

1986 • 12 citations

HYPOXIA AND HEPATIC DRUG METABOLISM – CLINICAL IMPLICATIONS

1990 • 10 citations

Blood oxygen tension-related change of theophylline clearance in experimental hypoxemia.

1989 • 10 citations

Reduction of portal pressure by chronic administration of isosorbide dinitrate in patients with cirrhosis: effects on systemic and splanchnic hemodynamics and liver function.

1992 • 8 citations

Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat

1993 • 7 citations

Lack of effect of verapamil and isosorbide dinitrate on the hepatic clearance of indocyanine green in cirrhosis.

1990 • 6 citations

Lack of hepatic benefit by oxygen inhalation during vasopressin infusion in patients with cirrhosis

1992 • 5 citations