Determinants of hepatic function in liver cirrhosis in the rat. Multivariate analysis.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Applied Regression Analysis and Other Multivariable Methods.

1979 • 1,491 citations

On the Theory of the Indicator-Dilution Method for Measurement of Blood Flow and Volume

1954 • 1,265 citations

Stereological Methods

1982 • 1,198 citations

Clearance concepts in pharmacokinetics

1973 • 741 citations

The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

1975 • 693 citations

Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension

1983 • 433 citations

RELATION OF THE PORTAL BLOOD TO LIVER MAINTENANCE

1920 • 340 citations

Sampling designs for stereology*

1981 • 334 citations

On the Uptake of Materials by the Intact Liver. THE TRANSPORT AND NET REMOVAL OF GALACTOSE

1973 • 295 citations

Measurement of portal–systemic shunting in the rat by using gamma-labeled microspheres

1981 • 244 citations

Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone.

1969 • 175 citations

Hepatic Circulation in Cirrhosis of the Liver

1952 • 165 citations

Aminopyrine demethylation measured by breath analysis in cirrhosis

1976 • 147 citations

The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: Correlation with morphometric measurement of hepatocyte mass

1987 • 146 citations

Assessment of liver microcirculation in human cirrhosis.

1982 • 143 citations

Hepatic microcirculation in the perfused cirrhotic rat liver.

1985 • 140 citations

Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver.

1986 • 135 citations

Determinants of Drug Disposition in Patients with Cirrhosis

1983 • 134 citations

Drug metabolism in liver disease: Activity of hepatic microsomal metabolizing enzymes

1979 • 133 citations

Quantitation of portasystemic shunting from the splenic and mesenteric beds in alcoholic liver disease

1972 • 133 citations

Mechanism for reduced drug clearance in patients with cirrhosis

1978 • 128 citations

Expiratory measurement of maximal amino-pyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, protacaval shunt and bile duct ligation in the rat.

1976 • 128 citations

Determination of the Hepatic Galactose Elimination Capacity after a Single Intravenous Injection in Man: The reproducibility and the influence of uneven distribution

1963 • 126 citations

Aminopyrine n-Demethylation: A Prognostic test of liver function in patients with alcoholic liver disease

1980 • 123 citations

Intact hepatocyte theory of impaired drug metabolism in experimental cirrhosis in the rat

1979 • 120 citations

Hepatic blood flow in alcoholic liver disease measured by an indicator dilution technic

1972 • 110 citations

Role of Portal and Splenic Vein Shunts and Impaired Hepatic Extraction in the Elevated Serum Bile Acids in Liver Cirrhosis

1984 • 107 citations

Hemodynamic Differences Between Alcoholic and Nonalcoholic Cirrhotics Following Distal Splenorenal Shunt—Effect on Survival?

1983 • 106 citations

Galactose elimination capacity as a prognostic index in patients with fulminant liver failure.

1976 • 99 citations

Prognostic value of the aminopyrine breath test in cirrhotic patients

1986 • 94 citations

Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver.

1978 • 87 citations

Diagnostic Effectiveness of Serum Bile Acids in Liver Diseases as Evaluated by Multivariate Statistical Methods

1983 • 85 citations

Aminopyrine N-demethylation by rats with liver cirrhosis

1987 • 83 citations

The Aminopyrine Breath Test and Serum Bile Acids Reflect Histologic Severity in Chronic Hepatitis

2007 • 81 citations

Prognostic significance of serum bile acids in cirrhosis

1986 • 74 citations

Test for Alcoholic Cirrhosis by Conversion of [14C] or [13C]Galactose to Expired CO2

1976 • 73 citations

Mechanisms for reduced hepatic clearance and elevated plasma levels of bile acids in cirrhosis

1981 • 54 citations

Criteria for Assessment of Functional Impairment in Patients with Cirrhosis of the Liver*

1973 • 52 citations

Increased Serum Bile Acids in Cirrhosis with Normal Transaminases

1982 • 47 citations

An Automated HPLC Method for the Assay of Propranolol and Its Basic Metabolites in Plasma and Urine

1982 • 44 citations

The portacaval and splenocaval shunt in the normal rat

1985 • 43 citations

Decreased uptake of taurocholate and ouabain by hepatocytes isolated from cirrhotic rat liver

1987 • 39 citations

Liver size and indices of drug metabolism in alcoholics

1978 • 37 citations

Impaired drug metabolism in experimental cirrhosis in the rat

1978 • 37 citations

The capacity of urea-N synthesis as a quantitative measure of the liver mass in rats

1986 • 33 citations

Congenital portacaval shunt in rats: Liver adaptation to lack of portal vein—a light and electron microscopic study

1985 • 32 citations

A simple assay for galactokinase using deae-cellulose column chromatography

1977 • 30 citations

Portal-systemic spill-over of bile acids: a study of mechanisms using ursodeoxycholic acid

1983 • 27 citations

The Quantitative Liver Function as Measured by the Galactose Elimination Capacity

1982 • 27 citations

Role of portasystemic shunts in the hyperkinetic circulation of the portal hypertensive rat.

1986 • 26 citations

The quantitative liver function as measured by the galactose elimination capacity. I. Diagnostic value and relations to clinical, biochemical, and histological findings in patients with steatosis and patients with cirrhosis.

1982 • 26 citations

Hepatocyte ultrastructure in rats with portacaval shunt

1982 • 25 citations

The levels of the mitochondrial and microsomal cytochromes in drinkers' livers

1978 • 21 citations

Altered liver function in diabetes: model experiments with aminopyrine in the rat.

1987 • 20 citations

Liver atrophy following portacaval shunt in normal rats —a morphometric study—

1977 • 16 citations

Preoperative Liver Function Tests Correlated with Encephalopathy after Porta-caval Anastomosis

1975 • 11 citations

Aminopyrine pharmacokinetics in the rat may depend on hepatic blood flow.

1986 • 7 citations