Soluble and Cellular Markers of T Cell Activation in Patients with Pulmonary Sarcoidosis

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

The Soluble Interleukin-2 Receptor: Biology, Function, and Clinical Application

1990 • 590 citations

Pulmonary Sarcoidosis: A Disease Characterized and Perpetuated by Activated Lung T-Lymphocytes

1981 • 426 citations

The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.

1991 • 245 citations

Current Concepts of the Pathogenesis of Sarcoidosis1,2

2015 • 239 citations

Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen.

1987 • 231 citations

Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis.

1991 • 203 citations

Biased accumulation of T lymphocytes with "memory"-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung.

1990 • 159 citations

The CD27⁻ subset of peripheral blood memory CD4⁺ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo

1992 • 157 citations

Enhanced alveolar macrophage-mediated antigen-induced T-lymphocyte proliferation in sarcoidosis.

1985 • 150 citations

Spontaneous release of interleukin 2 by lung T lymphocytes in active pulmonary sarcoidosis is primarily from the Leu3+DR+ T cell subset.

1986 • 135 citations

Respiratory Membrane Permeability and Bronchial Hyperreactivity in Patients with Stable Asthma: Effects of Therapy with Inhaled Steroids

1991 • 134 citations

Elevated Concentrations of Soluble Interleukin-2 Receptors in Serum Samples and Bronchoalveolar Lavage Fluids in Active Sarcoidosis

1988 • 127 citations

A soluble form of the human T cell differentiation antigen CD27 is released after triggering of the TCR/CD3 complex.

1991 • 125 citations

Compartmentalized activation of the interleukin 2 gene by lung T lymphocytes in active pulmonary sarcoidosis.

1986 • 116 citations

Interleukin 2 receptors are expressed by alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine treatment of normal human lung macrophages, blood monocytes, and monocyte cell lines.

1987 • 105 citations

Elevated levels of a soluble form of the T cell activation antigen CD27 in cerebrospinal fluid of multiple sclerosis patients

1991 • 96 citations

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis

1990 • 84 citations

T lymphocytes compartmentalized on the epithelial surface of the lower respiratory tract express the very late activation antigen complex VLA-1

1988 • 80 citations

T-Lymphocytes that Accumulate in the Lung in Sarcoidosis Have Evidence of Recent Stimulation of the T-Cell Antigen Receptor

1992 • 77 citations

Evidence of cells bearing interleukin-2 receptor at sites of disease activity in sarcoid patients.

1984 • 67 citations

Leu-8 antigen expression is diminished during cell activation but does not correlate with effector function of activated T lymphocytes.

1988 • 63 citations

Correlation of Clinical and Immunologic Parameters of the Inflammatory Activity of Pulmonary Sarcoidosis

1991 • 60 citations

Local immune complexes and inflammatory response in patients with chronic interstitial pulmonary disorders associated with collagen vascular diseases.

1984 • 46 citations

Expression of HLA Class II Genes in Alveolar Macrophages of Patients with Sarcoidosis

1989 • 40 citations

Soluble Interleukin 2 Receptors in Patients with Sarcoidosis

1992 • 39 citations

Most Human Pulmonary Infiltrating Lymphocytes Display the Surface Immune Phenotype and Functional Responses of Sensitized T Cells

1991 • 36 citations

Lamina propria lymphocytes are derived from circulating cells that lack the Leu-8 lymph node homing receptor

1991 • 30 citations

Anti‐CD27 monoclonal antibodies identify two functionally distinct subpopulations within the CD4⁺ T cell subset

1988 • 28 citations

Permeability or local production of immunoglobulins and other inflammatory proteins in asthma.

1991 • 23 citations

Helper Inducer T Cells in the Lungs of Sarcoidosis Patients

1989 • 18 citations

Serum levels of soluble CD27 in renal transplant recipients.

1992 • 18 citations

SERUM LEVELS OF SOLUBLE CD27 IN RENAL TRANSPLANT RECIPIENTS

1992 • 13 citations