Pulmonary Sarcoidosis: A Disease Characterized and Perpetuated by Activated Lung T-Lymphocytes

THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES

1962 • 2,726 citations

LEUKOCYTE LOCOMOTION AND CHEMOTAXIS

1973 • 1,709 citations

Glucocorticosteroid Therapy: Mechanisms of Action and Clinical Considerations

1976 • 1,035 citations

Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.

1979 • 958 citations

Elevation of serum angiotension-converting-enzyme (ACE) level in sarcoidosis

1975 • 865 citations

Increased superoxide anion production by immunologically activated and chemically elicited macrophages

1978 • 823 citations

Activated macrophages induce vascular proliferation

1977 • 818 citations

Manifestations of sarcoidosis

1963 • 801 citations

Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage.

1974 • 654 citations

Course and prognosis of sarcoidosis around the world

1974 • 526 citations

Normal Chest Roentgenograms in Chronic Diffuse Infiltrative Lung Disease

1978 • 480 citations

The Human Rosette-Forming Cell as a Marker of a Population of Thymus-Derived Cells

1972 • 479 citations

Tumor scanning with 67Ga citrate.

1969 • 469 citations

TRANSFORMATION OF MONOCYTES IN TISSUE CULTURE INTO MACROPHAGES, EPITHELIOID CELLS, AND MULTINUCLEATED GIANT CELLS

1966 • 449 citations

Secretion of a specific collagenase by stimulated macrophages.

1975 • 432 citations

Origin, Kinetics, and characteristics of pulmonary macrophages in the normal steady state.

1979 • 363 citations

Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.

1977 • 356 citations

The Pulmonary-Alveolar Macrophage

1979 • 331 citations

Gallium 67 citrate scanning in neoplastic and inflammatory lesions

1971 • 322 citations

Fate of Angiotensin I in the Circulation

1968 • 313 citations

Bronchoalveolar Lavage in Interstitial Lung Disease

1978 • 302 citations

Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells

1975 • 292 citations

Human Mononuclear Leukocyte Chemotaxis: A Quantitative Assay for Humoral and Cellular Chemotactic Factors

1972 • 290 citations

The formation and properties of macrophage polykaryons (inflammatory giant cells)

1974 • 285 citations

Secretory function of mononuclear phagocytes: a review.

1976 • 258 citations

Products of Activated Lymphocytes: Leukocyte Inhibitory Factor (LIF) Distinct from Migration Inhibitory Factor (MIF)

1974 • 254 citations

Leukotactic Factor Produced by Sensitized Lymphocytes

1969 • 239 citations

GLUCOCORTICOID SUPPRESSION OF MACROPHAGE MIGRATION INHIBITORY FACTOR

1973 • 235 citations

Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease.

1981 • 233 citations

Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

1980 • 233 citations

Origin and kinetics of monocytes and macrophages.

1970 • 223 citations

Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes.

1977 • 215 citations

IN-VITRO STUDIES OF LYMPHOCYTES FROM PATIENTS WITH SARCOIDOSIS AND LYMPHOPROLIFERATIVE DISEASES

1964 • 209 citations

The Differential Effect of In Vivo Hydrocortisone on the Kinetics of Subpopulations of Human Peripheral Blood Thymus-Derived Lymphocytes

1978 • 200 citations

Sarcoidosis: histopathological definition and clinical diagnosis.

1977 • 198 citations

Immunology of sarcoidosis

1975 • 198 citations

Serum angiotensin-converting enzyme for diagnosis and therapeutic evaluation of sarcoidosis.

1979 • 195 citations

Sarcoidosis: Clinical Features and Management

1967 • 194 citations

STRUCTURE AND FUNCTION IN SARCOIDOSIS*

1976 • 190 citations

A Human Mononuclear Leukocyte Chemotactic Factor: Characterization, Specificity and Kinetics of Production by Homologous Leukocytes

1973 • 186 citations

Transbronchial Lung Biopsy for the Diagnosis of Sarcoidosis

1975 • 171 citations

SERUM ANGIOTENSIN-CONVERTING ENZYME (SACE) IN SARCOIDOSIS AND OTHER GRANULOMATOUS DISORDERS

1978 • 164 citations

Usefulness of Serum Lysozyme Measurement in Diagnosis and Evaluation of Sarcoidosis

1973 • 163 citations

Clinical evaluation of 67 Ga-citrate scanning.

1972 • 156 citations

Localization of the immune response in sarcoidosis.

1979 • 155 citations

Nongranulomatous Interstitial Pneumonitis in Sarcoidosis

1978 • 153 citations

A Controlled Trial of Prednisone Treatment of Sarcoidosis¹

1973 • 146 citations

Induction of angiotensin converting enzyme in human monocytes in culture

1978 • 143 citations

The structure of mononuclear phagocytes differentiating in vivo. I. Sequential fine and histologic studies of the effect of Bacillus Calmette-Guerin (BCG).

1974 • 142 citations

Course and prognosis of sarcoidosis

1960 • 142 citations

Chemotactic Factor Inactivator in Normal Human Serum

1973 • 140 citations

67 Ga for tumor scanning.

1972 • 137 citations

ELEVATION OF ANGIOTENSIN‐CONVERTING ENZYME IN GRANULOMATOUS LYMPH NODES AND SERUM IN SARCOIDOSIS: CLINICAL AND POSSIBLE PATHOGENIC SIGNIFICANCE*

1976 • 135 citations

Immunologic reactivity of the lung: the in vivo and in vitro generation of a neutrophil chemotactic factor by alveolar macrophages.

1978 • 131 citations

Role of gallium 67 in inflammatory disease

1978 • 130 citations

Gallium-67 for Localization of Septic Lesions

1973 • 129 citations

PULMONARY SARCOIDOSIS

1973 • 124 citations

TREATMENT OF SARCOIDOSIS

1967 • 120 citations

Allergic hyperglobulinosis and hyalinosis (paramyloidosis) in the reticulo-endothelial system in Boeck's sarcoid and other conditions; a morphologic immunity reaction.

1948 • 119 citations

ALTERED IMMUNOLOGIC REACTIONS IN SARCOIDOSIS

1954 • 114 citations

THE SPECIFICITY AND NATURE OF SERUM‐ANGIOTENSIN‐CONVERTING ENZYME (SERUM ACE) ELEVATIONS IN SARCOIDOSIS*

1976 • 109 citations

Distribution of gallium in human tissues after intravenous administration.

1972 • 108 citations

Significance of basal lamina for regeneration of injured lung

1972 • 103 citations

Chemotaxis of Rat Lymphocytes

1977 • 101 citations

Gallium-67 citrate scanning in the staging of idiopathic pulmonary fibrosis: Correlation and physiologic and morphologic features and bronchoalveolar lavage.

1978 • 100 citations

Mechanisms of Extracellular Killing of Nucleated Mammalian Cells by Macrophages

1976 • 100 citations

Airway function in sarcoidosis

1977 • 99 citations

Two Distinct Chemotactic Factor Inactivators in Human Serum

1975 • 97 citations

The use of gallium-67 in pulmonary disorders

1978 • 94 citations

Evidence for circulating immune complexes in sarcoidosis.

1974 • 93 citations

Sarcoidosis. Typical and atypical thoracic manifestations and complications

1970 • 92 citations

Markedly elevated angiotensin converting enzyme in lymph nodes containing non-necrotizing granulomas in sarcoidosis.

1976 • 91 citations

MORPHOLOGY AND DISTRIBUTION OF THE CELLS OF A SARCOID GRANULOMA: ULTRASTRUCTURAL STUDY OF SERIAL SECTIONS

1976 • 85 citations

Leukotactic Dysfunction in Sarcoidosis

1976 • 81 citations

Pulmonary Function in Sarcoidosis

1958 • 81 citations

Diagnostic value of serum angiotensin converting enzyme activity in lung diseases.

1976 • 80 citations

Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell

1976 • 78 citations

Formation of multinucleate giant cells in organized epitheloid cell granulomas.

1974 • 75 citations

Cells, collagen and idiopathic pulmonary fibrosis

1978 • 74 citations

The fine structure of sarcoid and tuberculous granulomas

1970 • 74 citations

The Inhibitory Effect of Hydrocortisone on Lysis of Homologous Cells by Lymphocytes in Vitro

1962 • 71 citations

Lymphocyte Subpopulations in Sarcoidosis: Correlation with Disease Activity and Duration

1976 • 71 citations

Sarcoidosis: analysis of cells obtained by bronchial lavage.

1977 • 71 citations

Diagnostic Evaluation of⁶⁷Ga Scanning of Lung Cancer and Other Diseases

1971 • 71 citations

The Fibrinolytic Pathway of Human Plasma II. THE GENERATION OF CHEMOTACTIC ACTIVITY BY ACTIVATION OF PLASMINOGEN PROACTIVATOR

1973 • 69 citations

Interpretation of the 67 Ga photoscan.

1973 • 69 citations

Gallium-67 Scintigraphy of Pulmonary Diseases as a Complement to Radiography

1976 • 66 citations

Chloroquine in the treatment of sarcoidosis

1967 • 66 citations

Nodular Sarcoidosis: An Unusual Radiographic Appearance

1973 • 66 citations

Airway function in chronic pulmonary sarcoidosis with fibrosis.

1974 • 65 citations

Elevated serum angiotensin I converting enzyme in sarcoidosis.

1976 • 65 citations

Polymorphonuclear leukocyte and monocyte chemoattractants produced by human fibroblasts.

1979 • 63 citations

Immune Complexes in Sarcoidosis

1978 • 62 citations

Macrophage-lymphocyte interaction and antigen recognition.

1975 • 61 citations

GALLIUM 67 CITRATE SCANNING IN PATIENTS WITH PULMONARY SARCOIDOSIS

1974 • 61 citations

Fine structure and histochemistry of epithelioid cells in sarcoidosis

1974 • 59 citations

Pulmonary Sarcoidosis: A Prospective Evaluation of Glucocorticoid Therapy

1970 • 58 citations

Lymphocyte subpopulations in sarcoidosis.

1974 • 57 citations

EVIDENCE FOR CIRCULATING IMMUNE COMPLEXES IN ERYTHEMA NODOSUM AND EARLY SARCOIDOSIS

1976 • 57 citations

67Gallium Citrate Lung Scans in Interstitial Lung Disease

1976 • 54 citations

Pulmonary function in sarcoidosis

1953 • 54 citations

Diagnosis and Treatment of Sarcoidosis

1956 • 54 citations

Elastase-Like, Esteroprotease Activity in Human and Rabbit Alveolar Macrophage Granules

1971 • 52 citations

The definitive evaluation of sarcoidosis.

1970 • 51 citations

Serum angiotensin converting enzyme activity in sarcoidosis as measured by a simple radiochemical assay.

1979 • 51 citations

Modulation of the inflammatory response by products released from human polymorphonuclear leukocytes during phagocytosis

1975 • 51 citations

Elevation of Granulomatous Lymph-node and Serum Lysozyme in Sarcoidosis and Correlation with Angiotensin-converting Enzyme

1977 • 51 citations

The role of the Fc receptor (FcR) of thymus‐derived lymphocytes II. Presence of FcR on suppressor cells and direct involvement in suppression

1977 • 50 citations

Corticosteroids and circulating lymphocytes.

1975 • 50 citations

Morphogenesis in blood lymphocytes stimulated with phytohaemagglutinin (PHA). A light and electron microscopic study.

1971 • 49 citations

Chapter 6 The Human Alveolar Macrophage

1980 • 48 citations

Gallium Scanning As a Screening Test for Inflammatory Lesions

1975 • 46 citations

A ten-year study of corticosteroid treatment of pulmonary sarcoidosis.

1974 • 45 citations

ANTIBODIES TO T CELLS IN SARCOIDOSIS*

1976 • 45 citations

CORTISONE TREATMENT OF SARCOIDOSIS

1954 • 44 citations

Sarcoidosis: relationship between changes in lung structure and function.

1967 • 44 citations

Gallium Citrate Ga 67 Imaging in Patients With Suspected Inflammatory Processes

1975 • 42 citations

The effect of plasma upon lymphocyte response in vitro. Demonstration of a humoral inhibitor in patients with sarcoidosis.

1974 • 40 citations

Sarcoidosis and mononuclear phagocytes

1978 • 38 citations

Alteration of T-lymphocyte subpopulations in sarcoidosis

1978 • 38 citations

Tumor Detection with 67Ga-Citrate: A Literature Survey (1970-1978)

1978 • 38 citations

The importance of lymphocytes in pulmonary health and disease

1978 • 38 citations

Uncommon Roentgen Patterns of Pulmonary Sarcoidosis

1958 • 38 citations

THE USUAL UNUSUAL MANIFESTATIONS OF SARCOIDOSIS AND THE "HILAR HAZE"— A NEW DIAGNOSTIC AID

1974 • 37 citations

Occurrence of lung granulomas in patients with stage I sarcoidosis

1977 • 37 citations

The late stages of pulmonary sarcoidosis

1970 • 36 citations

Gallium-67 scintigraphy in lung diseases

1972 • 36 citations

Hydroxyl radical formation in phagocytic cells of the rat

1979 • 36 citations

LASMA AND CELL‐DERIVED INHIBITORS OF HUMAN NEUTROPHIL CHEMOTAXIS

1975 • 35 citations

Morphogenesis and Development of Sarcoid Lesions. Similarities to the Group of Collagenoses.

1964 • 33 citations

Serum-migration inhibitory activity in patients with sarcoidosis

1979 • 33 citations

Correlation of tuberculin-induced lymphocyte transformation with skin test reactivity and with clinical manifestations of sarcoidosis

1974 • 33 citations

PULMONARY FUNCTION IN STAGE I AND II PULMONARY SARCOIDOSIS*

1976 • 32 citations

Airway obstruction in pulmonary sarcoidosis.

1977 • 31 citations

Pulmonary and extrapulmonary sarcoidosis in relation to circulating immune complexes: a quantification of immune complexes by two radioimmunoassays.

1977 • 31 citations

Asteroid bodies: derivatives of the cytosphere. An electron microscopic contribution to the pathology of the cytocentre.

1977 • 29 citations

The effect of hydrocortisone on lymphocyte-mediated cytolysis

1973 • 29 citations

IMMUNOLOGICAL STUDIES IN SARCOIDOSIS: A COMPARISON OF DISEASE ACTIVITY AND VARIOUS IMMUNOLOGICAL PARAMETERS

1976 • 29 citations

The Course of Pulmonary Function in Sarcoidosis

1965 • 29 citations

Serum lysozyme in sarcoidosis. Evaluation of its usefulness in determination of disease activity.

1977 • 28 citations

Human monocyte spreading in vitro—Inducers and effects on Fc and C3 receptors

1976 • 28 citations

Sarcoidosis: Course and Treatment

1977 • 28 citations

Sarcoidosis: a correlation of dyspnea with roentgenographic stage and pulmonary function changes.

1974 • 27 citations

Changes in the Components of the Diffusing Capacity in Pulmonary Sarcoidosis

1963 • 27 citations

Sarcoidosis. A clinical review of 111 cases.

1961 • 27 citations

Sarcoid lymphocytes: spontaneous transformation and release of macrophage migration inhibition activity.

1976 • 27 citations

The Effect of Corticosteroid Treatment on Pulmonary Function in Sarcoidosis

1961 • 26 citations

The fine structure of human macrophage granules in sarcoidosis

1977 • 26 citations

Prognosis of Sarcoidosis

1970 • 26 citations

PULMONARY FUNCTION FOLLOW‐UP OF 120 PATIENTS WITH SARCOIDOSIS¹

1976 • 25 citations

Comparison of the Alveolitis of Sarcoidosis and Idiopathic Pulmonary Fibrosis

1979 • 24 citations

KINETICS OF MONOCYTE RECEPTOR ACTIVITY FOR IMMUNOPROTEINS IN PATIENTS WITH SARCOIDOSIS¹

1976 • 24 citations

Occurrence and significance of lymphopenia in sarcoidosis.

1968 • 23 citations

IMMUNOHISTOCHEMICAL DEMONSTRATION OF LYSOZYME IN THE LYMPH NODES AND KVEIM REACTION PAPULES IN SARCOIDOSIS

1977 • 22 citations

The pulmonary gas exchange during exercise in patients with pulmonary fibrosis.

1967 • 22 citations

Pulmonary Function in Diffuse Sarcoidosis

1974 • 20 citations

Cell-mediated immune responses in sarcoidosis.

1978 • 20 citations

ESTIMATION OF T‐ AND K‐CELL ACTIVITY IN THE PERIPHERAL BLOOD OF SARCOIDOSIS PATIENTS

1976 • 18 citations

Peripheral blood lymphocyte subpopulations in sarcoidosis

1975 • 18 citations

Sarcoidosis in Washington, DC

1970 • 18 citations

THE EFFECTS OF SARCOIDOSIS ON PULMONARY FUNCTION, WITH PARTICULAR REFERENCE TO CHANGES IN PULMONARY COMPLIANCE.

1965 • 17 citations

Pulmonary Fibrosis and Cor Pulmonale in Sarcoidosis

1954 • 16 citations

Sarcoidosis: correlation of delayed hypersensitivity, MLC reactivity and lymphocytotoxicity with disease activity.

1973 • 16 citations

MEMBRANE DIFFUSING CAPACITY AND PULMONARY CAPILLARY BLOOD VOLUME IN PULMONARY SARCOIDOSIS

1976 • 16 citations

Defective monocyte leukotaxis in sarcoidosis: possible relationship to a plasma factor.

1977 • 15 citations

The Formation of Stable E-Rosettes by Human T Lymphocytes Activated by Phytohemagglutinin

1977 • 15 citations

HISTOPATHOLOGY OF SARCOIDOSIS AND ITS IMMUNOLOGICAL BASES

1970 • 15 citations

The dynamics of granulomas and the significance of epithelioid cells.

1975 • 14 citations

Serum angiotensin-converting enzyme in sarcoidosis.

1980 • 12 citations

THE MECHANICS OF VENTILATION IN SARCOIDOSIS.

1964 • 11 citations

Serum and Urine Lysozyme in Sarcoidosis

1974 • 9 citations

Influence of steroid treatment on lymphocyte response in sarcoidosis

1975 • 9 citations

Increased proportion of active sheep erythrocyte rosette-forming lymphocytes and plasma rosette enhancement in sarcoidosis.

1979 • 8 citations

Changes in connective tissue in sarcoid granuloma: Hyalin, Paraamyloid and Fibrinoid. Electron Microscopic Study of 11 Cases

1969 • 8 citations

Intermittent neutrophil-monocyte bactericidal defects in a patient with sarcoidosis.

1975 • 8 citations

Early Onset Sarcoidosis with Pulmonary Function Abnormalities

1974 • 7 citations

Oxygen cost of breathing. II. Studies in patients with sarcoidosis.

1968 • 7 citations

Evaluation of the clinical and histological features of paratracheal and hilar gland enlargement

1970 • 6 citations

Pulmonary Function in Sarcoidosis

1968 • 5 citations

Gallium Detection of Inflammation

1974 • 4 citations

Obstructive Lung Disease in Pulmonary Sarcoidosis

1964 • 4 citations

Epithelioid cell and sarcoid-like granuloma. A review of human and experimental material.

1977 • 4 citations

[Gallium 67 citrate scintigraphy. II. Clinical aspects].

1977 • 4 citations

Anatomic correlations in radiogallium imaging of the peritoneum and retroperitoneum

1979 • 2 citations