Regulation of microglial function by interferons

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Production of superoxide anions by a CNS macrophage, the microglia

1987 • 619 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain

1989 • 504 citations

Laboratory Manual of Neutrophil Function

1986 • 443 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin

1988 • 390 citations

MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon

1987 • 346 citations

Molecular Transductional Mechanisms by which IFNγ and Other Signals Regulate Macrophage Development

1987 • 266 citations

Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro

1989 • 225 citations

Interferons as macrophage-activating factors. III. Preferential effects of interferon-gamma on the interleukin 1 secretory potential of fresh or aged human monocytes.

1985 • 217 citations

Chemotaxis by a CNS macrophage, the microglia

1990 • 215 citations

IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma.

1988 • 155 citations

Astrocytes produce interferon that enhances the expression of H-2 antigens on a subpopulation of brain cells.

1986 • 141 citations

Interferon enhances the excitability of cultured neurones

1979 • 128 citations

Regulation of interleukin 1 production by mouse peritoneal macrophages. Effects of arachidonic acid metabolites, cyclic nucleotides, and interferons.

1986 • 127 citations

Interferon-β impairs induction of HLA-DR antigen expression in cultured adult human astrocytes

1989 • 98 citations

Differential effects of interferon-alpha and interferon-gamma on interleukin 1 secretion by monocytes.

1987 • 95 citations

Potent activation of mouse macrophages by recombinant interferon-gamma.

1984 • 89 citations

Interferon Suppresses Sympathetic Neuronal Cell Death Caused by Nerve Growth Factor Deprivation

1990 • 84 citations

Interferon‐gamma‐like immunoreactivity in certain neurons of the central and peripheral nervous system

1989 • 83 citations

Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta.

1988 • 77 citations

Fc receptor density, MHC antigen expression and superoxide production are increased in interferon-gamma-treated microglia isolated from adult rat brain.

1989 • 69 citations

Astrocytes as antigen-presenting cells. Part II: Unlike H-2K-dependent cytotoxic T cells, H-2Ia-restricted T cells are only stimulated in the presence of interferon-γ

1986 • 65 citations

Immunobiology of Microglial Cellsa

1988 • 64 citations

Interferon induces astrocyte maturation causing an increase in cholinergic properties of cultured human spinal cord cells

1989 • 60 citations

MIF-like activity of natural and recombinant human interferon-gamma and their neutralization by monoclonal antibody.

1985 • 59 citations

Comparison and quantitation of Ia antigen expression on cultured macroglia and ameboid microglia from Lewis rat cerebral cortex: analyses and implications

1989 • 56 citations

Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization.

1984 • 52 citations

Demonstration of α, β, and γ Interferon in Active Chronic Multiple Sclerosis Lesionsa

1988 • 39 citations

Immunological functions of macrophages and their regulation by interferons.

1985 • 39 citations

Interferon in Biopsy and Autopsy Specimens of Brain

1980 • 31 citations

The effects of interferons on macrophages and their precursors

1987 • 27 citations

Regulation of Interleukin 1 Production by Alpha and Beta Interferons: Evidence for Both Direct and Indirect Enhancement

1985 • 24 citations

Interferon gamma-treated human macrophages display enhanced cytolysis and generation of reactive oxygen metabolites but reduced ingestion upon Fc receptor triggering

1989 • 19 citations

Interferons Affect Oxygen Metabolism in Human Neutrophil Granulocytes

1988 • 17 citations

Pleiotropic activities of human interferons are mediated by multiple response pathways.

1984 • 15 citations

Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis.

1989 • 14 citations

Interferon-γ Reduces Actin Filaments and Inhibits Thyroid-Stimulating Hormone-Induced Formation of Microvilli and Pseudopods in Mouse Monolayer Thyrocytes

1990 • 12 citations

Interferon-γ Enhances Superoxide Production by HL-60 Cells Stimulated with Multiple Agonists

1991 • 12 citations

Nitroblue tetrazolium reduction in monocytes and monocyte‐derived macrophages

1989 • 11 citations