Why can't cytotoxic T cells handle HIV?

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

1995 • 882 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

1994 • 553 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Roles of alphabeta and gammadelta T Cell Subsets in Viral Immunity

1992 • 350 citations

The Binding and Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 312 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo

1984 • 296 citations

Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV

1993 • 223 citations

Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors.

1995 • 163 citations

Therapeutic Reconstitution of Human Viral Immunity by Adoptive Transfer of Cytotoxic T Lymphocyte Clones

1994 • 47 citations

Cytotoxic Lymphocytes: Two ways to kill target cells

1994 • 40 citations