Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

2005 • 2,046 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

2001 • 1,779 citations

A germline-specific class of small RNAs binds mammalian Piwi proteins

2006 • 1,629 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

A novel class of small RNAs bind to MILI protein in mouse testes

2006 • 1,439 citations

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

2004 • 1,406 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing

2001 • 1,282 citations

Ribo-gnome: The Big World of Small RNAs

2005 • 1,276 citations

A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal

1998 • 955 citations

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

2002 • 874 citations

miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis

2002 • 840 citations

Systemic RNAi in C. elegans Requires the Putative Transmembrane Protein SID-1

2002 • 833 citations

Mili, a mammalian member ofpiwifamily gene, is essential for spermatogenesis

2004 • 745 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

2003 • 690 citations

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

1997 • 663 citations

Sequence-Specific Inhibition of Small RNA Function

2004 • 577 citations

Transport of dsRNA into Cells by the Transmembrane Protein SID-1

2003 • 570 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

2002 • 538 citations

RNAi: The Nuts and Bolts of the RISC Machine

2005 • 474 citations

A Dicer-2-Dependent 80S Complex Cleaves Targeted mRNAs during RNAi in Drosophila

2004 • 417 citations

Functional Anatomy of a dsRNA Trigger

2000 • 397 citations

RNase III enzymes and the initiation of gene silencing

2004 • 387 citations

Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways

2006 • 378 citations

RISC Assembly Defects in the Drosophila RNAi Mutant armitage

2004 • 377 citations

Transformation and microinjection

2006 • 293 citations

Highly efficient chemical synthesis of 2′-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleases

1989 • 268 citations

A New Marker for Mosaic Analysis in Caenorhabditis elegans Indicates a Fusion Between hyp6 and hyp7, Two Major Components of the Hypodermis

1998 • 217 citations

The Role of the RNAi Machinery in Heterochromatin Formation

2005 • 208 citations

Regulation of heterochromatin by histone methylation and small RNAs

2004 • 207 citations

Characterization of Mutations Induced by Ethyl Methanesulfonate, UV, and Trimethylpsoralen in the Nematode Caenorhabditis elegans

2000 • 206 citations

Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans

2006 • 203 citations

Cellular RNA-Dependent RNA Polymerase Involved in Posttranscriptional Gene Silencing Has Two Distinct Activity Modes

2002 • 191 citations

PPW-1, a PAZ/PIWI Protein Required for Efficient Germline RNAi, Is Defective in a Natural Isolate of C. elegans

2002 • 179 citations

Transcriptional silencing of a transgene by RNAi in the soma ofC. elegans

2005 • 174 citations

Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences

2005 • 140 citations

A Member of the Polymerase β Nucleotidyltransferase Superfamily Is Required for RNA Interference in C. elegans

2005 • 123 citations

Argonaute and RNA — getting into the groove

2006 • 80 citations

Poster: RNA Silencing

2005 • 5 citations