Highly efficient chemical synthesis of 2′-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleases

Polymer support oligonucleotide synthesis XVIII^1.2): use ofβ-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

1984 • 840 citations

Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides

1987 • 356 citations

Base pairing involving deoxyinosine: implications for probe design

1985 • 330 citations

Sequence‐dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

1987 • 261 citations

Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine.

1985 • 237 citations

Isolation and Characterization of an Endonuclease from Escherichia coli Specific for Ribonucleic Acid in Ribonucleic Acid·Deoxyribonucleic Acid Hybrid Structures

1973 • 223 citations

Site-directed cleavage of RNA

1987 • 124 citations

The synthesis of oligonucleotides containing a primary amino group at the 5'-terminus

1987 • 109 citations

Synthesis of O2'-Methyluridine, O2'-Methylcytidine, N4,O2'-Dimethylcytidine and N4,N4,O2'-Trimethylcytidine from a Common Intermediate.

1986 • 31 citations

A new linkage for solid phase synthesis of oligodeoxyribonucleotides

1985 • 31 citations

A new condensing reagent, 1-(2,4,6-triisopropylbenzenesulfonyl)-5-(pyridin-2-yl)tetrazolide and its use in the synthesis of λ cro binding heptadecanucleotide on a polymer support

1982 • 16 citations

Sequence-specific cleavage of RNA using chimeric DNA splints and RNase H.

1988 • 13 citations

Synthesis and properties of novel nucleic acid probes.

1985 • 10 citations

A new method for the unidirectional deletion of DNA with Bal 31 nuclease using 2'-O-MeRNA-DNA chimeric adaptors.

1988 • 4 citations