Deficiency in integrin-mediated transmembrane signaling and microfilament stress fiber formation by aging dermal fibroblasts from normal and down's syndrome patients

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Cell Surface Receptors for Extracellular Matrix Molecules

1987 • 793 citations

Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits.

1987 • 727 citations

The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells.

1990 • 629 citations

Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells

1991 • 379 citations

The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin.

1990 • 288 citations

Human Skin Fibroblasts Derived from Papillary and Reticular Dermis: Differences in Growth Potential in Vitro

1979 • 276 citations

Connective Tissue Biochemistry of the Aging Dermis

1986 • 264 citations

The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.

1988 • 258 citations

Extracellular Matrix Assembly

1988 • 250 citations

Endocytosis and recycling of the fibronectin receptor in CHO cells.

1989 • 231 citations

Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation.

1988 • 228 citations

Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness

1989 • 216 citations

Membrane receptors for extracellular matrix macromolecules: relationship to cell adhesion and tumor metastasis

1987 • 184 citations

The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors

1991 • 151 citations

Tissue-specific splicing pattern of fibronectin messenger RNA precursor during development and aging in rat.

1991 • 145 citations

In vivo analyses of integrin beta 1 subunit function in fibronectin matrix assembly.

1990 • 127 citations

Collagen processing, crosslinking, and fibril bundle assembly in matrix produced by fibroblasts in long-term cultures supplemented with ascorbic acid

1989 • 116 citations

Skin and Aging Processes

1984 • 106 citations

A hypothetical explanation for the aging of skin. Chronologic alteration of the three-dimensional arrangement of collagen and elastic fibers in connective tissue.

1989 • 105 citations

Dynamic cytoskeleton-integrin associations induced by cell binding to immobilized fibronectin.

1989 • 101 citations

Fixation of mammalian cells for flow cytometric evaluation of DNA content and nuclear immunofluorescence

1992 • 88 citations

Cell-type-specific expression of alternatively spliced human fibronectin IIICS mRNAs.

1990 • 65 citations

Collagen can modulate cell interactions with fibronectin.

1985 • 63 citations

The interaction of human papillary and reticular fibroblasts and human keratinocytes in the contraction of three-dimensional floating collagen lattices

1989 • 60 citations

Internalization of the fibronectin receptor is a constitutive process

1990 • 55 citations

Multiple ligand binding functions for VLA-2 α2β1 and VLA-3 (α3β1) in the integrin family

1990 • 53 citations

Complementary adhesive responses of human skin fibroblasts to the cell-binding domain of fibronectin and the heparan sulfate-binding protein, platelet factor-4

1984 • 48 citations

Skin and aging processes

1985 • 30 citations

Differential extracellular matrix gene expression by fibroblasts during their proliferative life span in vitro and at senescence

1992 • 29 citations

Adhesion of human dermal reticular fibroblasts on complementary fragments of fibronectin: Aging in vivo or in vitro

1988 • 28 citations

Association between fibronectin receptor and the substratum: Spare receptors for cell adhesion

1987 • 25 citations

Glycosaminoglycan distribution in substratum adhesion sites of aging human skin fibroblasts, including papillary and reticular subpopulations

1985 • 22 citations

Proteoglycans in the substratum adhesion sites of human papillary or reticular dermal fibroblasts. Aging in vivo or in vitro

1986 • 20 citations

Neurite outgrowth in dorsal root neuronal hybrid clones modulated by ganglioside GM1 and disintegrins

1991 • 18 citations

Changes in fibronectin mRNA splicing with in vitro passage

1991 • 15 citations

Aging-related changes and topology of adhesion responses sensitive to cycloheximide on collagen substrata by human dermal fibroblasts

1990 • 11 citations

Dermal fibroblasts from Down's syndrome patients share a cycloheximide-induced deficiency in collagen adhesion responses with normal aging cells

1990 • 11 citations