The cerebellum in Parkinson’s disease

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THE BASAL GANGLIA: FOCUSED SELECTION AND INHIBITION OF COMPETING MOTOR PROGRAMS

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Five-Year Follow-up of Bilateral Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease

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Mitochondrial Complex I Deficiency in Parkinson's Disease

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Basal ganglia and cerebellar loops: motor and cognitive circuits

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Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus

1991 • 1,712 citations

Cerebellum and Nonmotor Function

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A Five-Year Study of the Incidence of Dyskinesia in Patients with Early Parkinson's Disease Who Were Treated with Ropinirole or Levodopa

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Looking into the functional architecture of the brain with diffusion MRI

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The Thalamus

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The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography

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Cerebellar Projections to the Prefrontal Cortex of the Primate

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Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

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Discussion

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Functional anatomy of the basal ganglia

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1991 • 900 citations

Functional reorganization of the brain in recovery from striatocapsular infarction in man

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The cerebellum communicates with the basal ganglia

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Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease

2007 • 777 citations

Self-initiated versus externally triggered movements

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The basal ganglia communicate with the cerebellum

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Impaired mesial frontal and putamen activation in Parkinson's disease: A positron emission tomography study

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Dynamic functional reorganization of the motor execution network after stroke

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Cortical motor reorganization in akinetic patients with Parkinson's disease

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Parkinson's disease symptoms: The patient's perspective

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The Neuropathologic Basis of Different Clinical Subgroups of Parkinson's Disease

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The cerebral oscillatory network of parkinsonian resting tremor

2002 • 532 citations

Pallidal vs Subthalamic Nucleus Deep Brain Stimulation in Parkinson Disease

2005 • 504 citations

Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies

2001 • 482 citations

Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa

2001 • 480 citations

A functional MRI study of automatic movements in patients with Parkinson's disease

2005 • 464 citations

In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease

2000 • 441 citations

Comorbidity of the nonmotor symptoms of Parkinson's disease

2001 • 409 citations

Role of hyperactive cerebellum and motor cortex in Parkinson's disease

2007 • 389 citations

Changes in network activity with the progression of Parkinson's disease

2007 • 383 citations

Regional homogeneity changes in patients with Parkinson's disease

2008 • 382 citations

Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor

2011 • 381 citations

Prevalence of smell loss in Parkinson's disease – A multicenter study

2009 • 376 citations

Metabolic brain networks in neurodegenerative disorders: a functional imaging approach

2009 • 373 citations

Changes of functional connectivity of the motor network in the resting state in Parkinson's disease

2009 • 361 citations

Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data

1990 • 343 citations

Network modulation in the treatment of Parkinson's disease

2006 • 343 citations

Cognitive Impairment and the Brain Dopaminergic System in Parkinson Disease

2000 • 336 citations

Metabolic brain networks associated with cognitive function in Parkinson's disease

2006 • 334 citations

Pharmacologically modulated fMRI---cortical responsiveness to levodopa in drug‐naive hemiparkinsonian patients

2003 • 309 citations

Mechanisms underlying gait disturbance in Parkinson's disease

1999 • 290 citations

Abnormal Metabolic Network Activity in Parkinson'S Disease: Test—Retest Reproducibility

2006 • 288 citations

Nonlinear Progression of Parkinson Disease as Determined by Serial Positron Emission Tomographic Imaging of Striatal Fluorodopa F 18 Activity

2005 • 283 citations

Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke

2002 • 267 citations

Ad hoc reviewers

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Genetic variability in the SNCA gene influences α‐synuclein levels in the blood and brain

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The pathophysiology of parkinsonian tremor: a review

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Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects

2010 • 239 citations

Vicarious function within the human primary motor cortex?

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Behavioral planning in the prefrontal cortex

2001 • 228 citations

The primate motor thalamus

1996 • 223 citations

Neural correlates of dual task performance in patients with Parkinson's disease

2007 • 219 citations

Thalamic Deep Brain Stimulation for Essential Tremor: Relation of Lead Location to Outcome

2004 • 219 citations

Abnormalities in the stride length‐cadence relation in parkinsonian gait

1998 • 214 citations

Cortical dysfunction in non-demented Parkinson's disease patients: A combined 31P-MRS and 18FDG-PET study

2000 • 214 citations

Subthalamic Nucleus Stimulation Restores Glucose Metabolism in Associative and Limbic Cortices and in Cerebellum: Evidence from a FDG-PET Study in Advanced Parkinson's Disease

2003 • 212 citations

A PET study of sequential finger movements of varying length in patients with Parkinson's disease

1999 • 211 citations

Basal ganglia oscillations and pathophysiology of movement disorders

2006 • 210 citations

The discovery of dopamine deficiency in the parkinsonian brain

2006 • 207 citations

Effective connectivity of brain networks during self-initiated movement in Parkinson's disease

2010 • 205 citations

The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients

1997 • 203 citations

Thalamic stimulation and suppression of parkinsonian tremor

1993 • 201 citations

Dopaminergic and non-dopaminergic neurons in the ventral tegmental area of the rat project, respectively, to the cerebellar cortex and deep cerebellar nuclei

1992 • 198 citations

Expression of ?-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's disease

2000 • 195 citations

Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease

2009 • 195 citations

Abnormalities in Metabolic Network Activity Precede the Onset of Motor Symptoms in Parkinson's Disease

2010 • 192 citations

Dopaminergic modulation of striato-frontal connectivity during motor timing in Parkinson's disease

2010 • 171 citations

Striatal and extrastriatal dysfunction in Parkinson’s disease with dementia: a 6‐[18F]fluoro‐l‐dopa PET study

2002 • 166 citations

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease

2008 • 162 citations

Neural correlates of bimanual anti-phase and in-phase movements in Parkinson's disease

2010 • 162 citations

Nonmotor complications in Parkinson's disease

2005 • 161 citations

Functional Mapping of Human Brain in Olfactory Processing: A PET Study

2000 • 155 citations

The roles of the cerebellum and basal ganglia in timing and error prediction

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Assessment of the progression of Parkinson's disease: a metabolic network approach

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Levels of alpha‐synuclein mRNA in sporadic Parkinson disease patients

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Neuronal recordings in Parkinson's disease patients with dyskinesias induced by apomorphine.

2000 • 146 citations

Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes

2010 • 145 citations

Normalizing motor-related brain activity

2006 • 145 citations

Akineto-rigid vs. tremor syndromes in Parkinsonism

2009 • 144 citations

Tyrosine Hydroxylase- and Dopamine Transporter-Immunoreactive Axons in the Primate Cerebellum Evidence for a Lobular- and Laminar-Specific Dopamine Innervation

2000 • 143 citations

A di-synaptic projection from the lateral cerebellar nucleus to the laterodorsal part of the striatum via the central lateral nucleus of the thalamus in the rat

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Relationships Among the Metabolic Patterns That Correlate With Mnemonic, Visuospatial, and Mood Symptoms in Parkinson’s Disease

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Nonmotor fluctuations in patients with Parkinson's disease

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Involvement of the cerebellothalamocortical pathway in Parkinson disease

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The Basal Ganglia Ii: Structure And Function-Current Concepts

2012 • 133 citations

Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

2011 • 133 citations

Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease

2005 • 131 citations

Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease

2006 • 131 citations

Morphological differences in Parkinson’s disease with and without rest tremor

2009 • 127 citations

The functional anatomy of parkinsonian bradykinesia

2003 • 126 citations

Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor

1995 • 123 citations

Pathology of Parkinson's disease

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Human Cerebellum Plays an Important Role in Memory-Timed Finger Movement: An fMRI Study

2000 • 119 citations

Subthalamic Nucleus Stimulation Reduces Abnormal Motor Cortical Overactivity in Parkinson Disease

2004 • 116 citations

Voxel-based analysis of diffusion tensor indices in the brain in patients with Parkinson's disease

2009 • 111 citations

MUSCLE TONE IN PARKINSONIAN STATES

1930 • 111 citations

Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: A [¹⁵O] H₂O PET study

2009 • 106 citations

Effective connectivity of neural networks in automatic movements in Parkinson's disease

2009 • 105 citations

Connectivity of the pedunculopontine nucleus in parkinsonian freezing of gait

2010 • 100 citations

?-Synuclein expression in substantia nigra and cortex in Parkinson's disease

1999 • 98 citations

The cerebellum and olfaction in the aging brain: a functional magnetic resonance imaging study

2003 • 97 citations

Dynamic changes in cerebello-thalamo-cortical motor circuitry during progression of Parkinson's disease

2009 • 96 citations

Dopaminergic innervation and binding in the rat cerebellum

1991 • 95 citations

Alteration in α‐synuclein mRNA expression in Parkinson's disease

2003 • 95 citations

Voxel-based morphometry reveals extra-nigral atrophy patterns associated with dopamine refractory cognitive and motor impairment in parkinsonism

2008 • 92 citations

Dissociation between contingent negative variation and Bereitschaftspotential in a patient with cerebellar efferent lesion

1994 • 91 citations

A deformation‐based morphometry study of patients with early‐stage Parkinson’s disease

2009 • 89 citations

Joint amplitude and connectivity compensatory mechanisms in Parkinson's disease

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Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies

2004 • 87 citations

Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT‐PCR

2003 • 85 citations

Thalamic stimulation for parkinsonian tremor: correlation between regional cerebral blood flow and physiological tremor characteristics

2003 • 84 citations

Progression of Parkinson Disease

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Enhancement of brain activation during trial-and-error sequence learning in early PD

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Increased Dependence of Action Selection on Recent Motor History in Parkinson's Disease

2009 • 81 citations

Tremor‐related activity of neurons in the ‘motor’ thalamus: changes in firing rate and pattern in the MPTP vervet model of parkinsonism

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The Subthalamic Nucleus in Primary Dystonia: Single-Unit Discharge Characteristics

2009 • 73 citations

Immunohistochemical localization of glutamate, glutaminase and aspartate aminotransferase in neurons of the pontine nuclei of the rat

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STN‐stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection

2007 • 73 citations

Metabolic activity of cerebellar and basal ganglia-thalamic neurons is reduced in parkinsonism

2006 • 72 citations

Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans

2007 • 71 citations

Structural brain correlates of verbal fluency in Parkinson's disease

2009 • 71 citations

Why Patients With Parkinson's Disease Fall

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Levodopa-sensitive, dynamic changes in effective connectivity during simultaneous movements in Parkinson's disease

2008 • 69 citations

Compensatory cortical mechanisms in Parkinson's disease evidenced with fMRI during the performance of pre-learned sequential movements

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Low-frequency repetitive transcranial magnetic stimulation for treatment of levodopa-induced dyskinesias

2007 • 68 citations

Corticolimbic gray matter loss in Parkinson’s disease without dementia

2010 • 67 citations

Olfactory Impairments in Patients with Unilateral Cerebellar Lesions Are Selective to Inputs from the Contralesional Nostril

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Rule learning in a serial reaction time task: An fMRI study on patients with early Parkinson’s disease

2003 • 66 citations

Influences of cerebellar hemispherectomy on slow potentials in the motor cortex preceding self-paced hand movements in the monkey

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Olfactory dysfunction in degenerative ataxias

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Metabolic changes induced by theta burst stimulation of the cerebellum in dyskinetic Parkinson’s disease patients

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Levodopa affects functional brain networks in parkinsonian resting tremor

2008 • 57 citations

α-Synuclein pathology affecting Bergmann glia of the cerebellum in patients with α-synucleinopathies

2002 • 55 citations

Alpha‐synuclein mRNA expression in sporadic Parkinson's disease

2005 • 52 citations

Clinical and cerebral activity changes induced by subthalamic nucleus stimulation in advanced Parkinson's disease: A prospective case-control study

2008 • 48 citations

Reward Processing in Health and Parkinson's Disease: Neural Organization and Reorganization

2003 • 47 citations

The Metabolic Substrates of Bradykinesia and Tremor in Uncomplicated Parkinson's Disease

2002 • 47 citations

On a basal ganglia role in learning and rehearsing visual–motor associations

2009 • 45 citations

Dopamine transporters in the cerebellum of mutant mice

2005 • 44 citations

Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats

2007 • 41 citations

Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys.

2012 • 41 citations

Altered Brain Activation and Connectivity in Early Parkinson Disease Tactile Perception

2011 • 40 citations

MPTP neurotoxicity to cerebellar Purkinje cells in mice

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Network biomarkers for the diagnosis and treatment of movement disorders

2008 • 37 citations

Cerebellar αsynuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material

2008 • 36 citations

Cerebellar nuclei are activated by high-frequency stimulation of the subthalamic nucleus

2011 • 35 citations

Pathological oscillatory coupling within the human motor system in different tremor syndromes as revealed by magnetoencephalography.

2004 • 35 citations

Olfactory impairment in familial ataxias

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Motor urgency is mediated by the contralateral cerebellum in Parkinson's disease

2008 • 33 citations

Studies of sensory and motor cortex physiology: with observations on akinesia in Parkinson's disease.

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The role of σ-receptors in levodopa-induced dyskinesia in patients with advanced Parkinson disease: a positron emission tomography study

2004 • 23 citations

Contrasting Changes in Cortical Activation Induced by Acute High-Frequency Stimulation within the Globus Pallidus in Parkinson's Disease

2008 • 20 citations

THALAMIC DEEP BRAIN STIMULATION FOR ESSENTIAL TREMOR

2008 • 20 citations

Changes in Glucose Metabolism in Cerebral Cortex and Cerebellum Correlate With Tremor and Rigidity Control by Subthalamic Nucleus Stimulation in Parkinson’s Disease: A Positron Emission Tomography Study

2007 • 17 citations

Cortical field potentials preceding self-paced forelimb movements and influences of cerebellectomy upon them in rats

2003 • 8 citations

Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

2011 • 2 citations