Parkinson's disease: clinical features and diagnosis

Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Process, format, and clinimetric testing plan

2006 • 1,240 citations

What features improve the accuracy of clinical diagnosis in Parkinson's disease

1992 • 1,232 citations

Falls and freezing of gait in Parkinson's disease: A review of two interconnected, episodic phenomena

2004 • 1,198 citations

An Essay on the Shaking Palsy

2002 • 1,151 citations

Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder

1996 • 1,063 citations

Sydney multicenter study of Parkinson's disease: Non‐<scp>L</scp>‐dopa–responsive problems dominate at 15 years

2004 • 1,013 citations

A Clinicopathologic Study of 100 Cases of Parkinson's Disease

1993 • 950 citations

Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease

2007 • 906 citations

Pathophysiology of bradykinesia in Parkinson's disease

2001 • 856 citations

Parkinson’s Disease and Movement Disorders

2005 • 811 citations

Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease

2001 • 795 citations

The diagnosis of Parkinson's disease

2005 • 794 citations

Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease

2007 • 777 citations

Idiopathic hyposmia as a preclinical sign of Parkinson's disease

2004 • 716 citations

Risk of dementia in Parkinson’s disease

2001 • 682 citations

Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's disease

2003 • 663 citations

Association of Dopamine Agonist Use With Impulse Control Disorders in Parkinson Disease

2006 • 654 citations

A PHYSIOLOGICAL MECHANISM OF BRADYKINESIA

1980 • 648 citations

Depression rating scales in Parkinson's disease: Critique and recommendations

2007 • 639 citations

Systematic evaluation of rating scales for impairment and disability in Parkinson's disease

2002 • 626 citations

Accuracy of Clinical Diagnosis in Parkinsonism — A Prospective Study

1991 • 594 citations

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

2008 • 538 citations

Hypocretin (orexin) cell loss in Parkinson's disease

2007 • 524 citations

Freezing of gait in PD: Prospective assessment in the DATATOP cohort

2001 • 522 citations

[The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia].

1961 • 515 citations

Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress

2006 • 498 citations

Is dopamine a physiologically relevant mediator of feeding behavior?

2007 • 439 citations

Hypocretin (orexin) loss in Parkinson's disease

2007 • 433 citations

Clinical correlates of selective pathology in the amygdala of patients with Parkinson’s disease

2002 • 421 citations

REM sleep behavior disorders in multiple system atrophy

1997 • 421 citations

Functional Decline in Parkinson Disease

2001 • 411 citations

Striatal D₂ receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with ¹¹C‐raclopride and positron emission tomography

1992 • 395 citations

Daytime sleepiness and other sleep disorders in Parkinson’s disease

2001 • 387 citations

Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases

2006 • 373 citations

Fear of falling and postural control in Parkinson's disease

2003 • 370 citations

Principles and Practice of Movement Disorders

2007 • 366 citations

[sup 123 I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease

1996 • 363 citations

Effects of Intensive Voice Treatment (the Lee Silverman Voice Treatment [LSVT]) on Vowel Articulation in Dysarthric Individuals With Idiopathic Parkinson Disease: Acoustic and Perceptual Findings

2007 • 357 citations

Which clinical sign of Parkinson's disease best reflects the nigrostriatal lesion?

1997 • 355 citations

Prevalence of orthostatic hypotension in Parkinson's disease

1997 • 351 citations

Falls and Parkinsonʼs Disease

1989 • 345 citations

Camptocormia

2005 • 333 citations

Fatigue in Parkinson's disease: A review

2006 • 328 citations

Predictors of freezing in Parkinson's disease: A survey of 6,620 patients

2007 • 299 citations

The impact of depressive symptoms in early Parkinson disease

2007 • 294 citations

Re-emergent tremor of Parkinson's disease

1999 • 287 citations

Quantitative measurement of pain sensation in patients with Parkinson disease

2004 • 278 citations

Handbook of Parkinson's Disease

2013 • 277 citations

Accuracy of diagnosis in patients with presumed Parkinson's disease

1999 • 270 citations

Parkinson's Disease and Movement Disorders

2003 • 252 citations

Apraxia in movement disorders

2005 • 250 citations

Parkinsonian signs and substantia nigra neuron density in decendents elders without PD

2004 • 248 citations

Freezing phenomenon in patients with parkinsonian syndromes

1997 • 231 citations

Camptocormia (bent spine) in patients with Parkinson's disease?Characterization and possible pathogenesis of an unusual phenomenon

1999 • 230 citations

Brain parenchyma sonography discriminates Parkinson's disease and atypical parkinsonian syndromes

2003 • 226 citations

Swallowing disorders in Parkinson's disease

2003 • 224 citations

Pain and motor complications in Parkinson's disease

2006 • 222 citations

The Evolution of Diagnosis in Early Parkinson Disease

2000 • 221 citations

Joint and skeletal deformities in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy

2006 • 218 citations

Exploring the relationship between essential tremor and Parkinson's disease

2006 • 211 citations

Insomnia in Parkinson's disease: frequency and progression over time

2006 • 209 citations

A population perspective on diagnostic criteria for Parkinson's disease

1997 • 207 citations

The discovery of dopamine deficiency in the parkinsonian brain

2006 • 207 citations

Effects of rhythmic sensory stimulation (auditory, visual) on gait in Parkinson’s disease patients

2008 • 206 citations

Medical Management of Levodopa-Associated Motor Complications in Patients with Parkinson???s Disease

2007 • 205 citations

ABNORMAL OCULAR MOVEMENTS IN PARKINSON'S DISEASE

1989 • 204 citations

Prognostic factors for the progression of Parkinson's disease: A systematic review

2007 • 199 citations

Postural instability in idiopathic Parkinson's disease: the role of medication and unilateral pallidotomy

2002 • 192 citations

Predictors of falls and fractures in bradykinetic rigid syndromes: a retrospective study

2006 • 189 citations

Excessive daytime sleepiness in Parkinson disease

2006 • 185 citations

Effect of chronic bilateral subthalamic nucleus (STN) stimulation on postural control in Parkinson's disease

2003 • 185 citations

“Tip‐of‐the‐tongue” phenomenon in Parkinson disease

1982 • 179 citations

Essential tremor: A heterogenous disorder

2002 • 176 citations

Frozen shoulder and other shoulder disturbances in Parkinson's disease.

1989 • 174 citations

The role of sensory cues in the rehabilitation of parkinsonian patients: A comparison of two physical therapy protocols

2000 • 170 citations

Rate of clinical progression in Parkinson's disease. A prospective study

2007 • 160 citations

Sweating dysfunction in Parkinson's disease

2003 • 159 citations

Slowed central processing in simple and go/no-go reaction time tasks in Parkinson's disease

1994 • 157 citations

Olfactory function in Parkinson's disease subtypes

1994 • 155 citations

Estimated life expectancy of Parkinson's patients compared with the UK population

2007 • 155 citations

Progression of falls in postmortem-confirmed Parkinsonian disorders

1999 • 154 citations

Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease

2004 • 152 citations

Parkinson's disease with camptocormia

2006 • 151 citations

Speech disorders of Parkinsonism: a review.

1981 • 150 citations

A study of salivary secretion in Parkinson's disease.

1999 • 148 citations

Parkinson's disease

1973 • 139 citations

Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's disease

2006 • 138 citations

Predictors of mortality among nursing home residents with a diagnosis of Parkinson's disease.

2002 • 137 citations

Punding prevalence in Parkinson's disease

2007 • 132 citations

Postural instability in Parkinson's disease

1992 • 128 citations

Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease

1996 • 128 citations

The functional anatomy of parkinsonian bradykinesia

2003 • 126 citations

Cholinergic–Dopaminergic Imbalance in Pisa Syndrome

2003 • 126 citations

Tip of the Tongue

2009 • 124 citations

Are Parkinson disease patients protected from some but not all cancers?

2007 • 122 citations

Does This Patient Have Parkinson Disease?

2003 • 117 citations

Striatal deformities of the hand and foot in Parkinson's disease

2005 • 116 citations

Oral and genital pain syndromes in Parkinson's disease

1996 • 113 citations

The effect of l-3,4-dihydroxyphenylalanine (=DOPA) on akinesia in parkinsonism

1998 • 112 citations

Apraxia of lid opening

1997 • 111 citations

Midbrain sonography in patients with essential tremor

2007 • 111 citations

Interhemispheric and ipsilateral connections in Parkinson's disease: Relation to mirror movements

2007 • 108 citations

The progression of Parkinson disease

2007 • 105 citations

Evaluation of a modified inverted walking stick as a treatment for Parkinsonian freezing episodes

1990 • 104 citations

Bradykinesia akinesia inco-ordination test (BRAIN TEST): an objective computerised assessment of upper limb motor function

1999 • 103 citations

Scales in Parkinson’s disease

2006 • 93 citations

Diabetes mellitus and progression of rigidity and gait disturbance in older persons

2004 • 93 citations

Bradykinesia Induced by Dopamine D2 Receptor Blockade Is Associated with Reduced Motor Cortex Activity in the Rat

2005 • 91 citations

Parkinsonism and Neck Extensor Myopathy

2001 • 91 citations

The relationship between parkinsonian rigidity and hypokinesia in the orofacial system

1982 • 91 citations

Parkinson's disease and driving ability

2006 • 91 citations

Systematic review of acute levodopa and apomorphine challenge tests in the diagnosis of idiopathic Parkinson's disease

2000 • 83 citations

Correlation between cardiac ¹²³I‐MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy

2006 • 82 citations

Phenomenology of dreams in Parkinson's disease

2006 • 80 citations

The Transition from Adolescence to Adult Life: Physiology of the ‘Transition’ Phase and Its Evolutionary Basis

2003 • 80 citations

Subjective Complaints Precede Parkinson Disease

2006 • 79 citations

Response to L-DOPA in Multiple System Atrophy

1993 • 75 citations

Smell identification ability in twin pairs discordant for Parkinson's disease

2005 • 72 citations

A new look at James Parkinson's Essay on the Shaking Palsy

2007 • 69 citations

Akathisia in Parkinson's disease

1994 • 65 citations

Modification of Parkinsonism???Chronic Treatment with L-Dopa

1969 • 65 citations

Contribution of Jules Froment to the study of Parkinsonian rigidity

2007 • 64 citations

Nonmotor symptoms of Parkinson’s disease

2006 • 64 citations

Sweating in Parkinsonian patients with wearing‐off

2007 • 64 citations

Botulinum toxin in the treatment of tremors, dystonias, sialorrhea and other symptoms associated with Parkinson’s disease

2007 • 60 citations

Respiratory function in Parkinson's disease.

1998 • 60 citations

Non-motor Symptoms of Parkinson's Disease

2007 • 58 citations

Internal tremor in patients with Parkinson's disease

1996 • 56 citations

Glabellar and palmomental reflexes in parkinsonian disorders

2004 • 51 citations

The Metabolic Substrates of Bradykinesia and Tremor in Uncomplicated Parkinson's Disease

2002 • 47 citations

Cognitive slowing in Parkinson disease is accompanied by hypofunctioning of the striatum

2007 • 45 citations

Postural control in Parkinson's disease after unilateral posteroventral pallidotomy

2000 • 42 citations

Primitive reflexes in healthy, adult volunteers and neurological patients: methodological issues

1993 • 41 citations

New developments of brain imaging for Parkinson's disease and related disorders

2006 • 40 citations

Blinking and the Release Reflexes: Are They Clinically Useful?

1994 • 35 citations

Smooth pursuit during dose‐related on‐off fluctuations in Parkinson's disease

1987 • 30 citations

Levodopa‐induced ocular dyskinesias in Parkinson's disease

2002 • 28 citations

The frequency and significance of ‘striatal toe’ in parkinsonism

2002 • 23 citations

Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy

2007 • 21 citations

Long-Term Follow-Up of Spontaneous Development in a Boy with Familial Male Precocious Puberty

2004 • 20 citations

The Metabolic Substrates of Bradykinesia and Tremor in Uncomplicated Parkinson's Disease

2002 • 9 citations

R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation

2006 • 8 citations

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