Interaction of chemical carcinogens with macromolecules

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES

1963 • 801 citations

DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair

1979 • 562 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

An evaluation of 6 short-term tests for detecting organic chemical carcinogens

1978 • 427 citations

Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate

1968 • 378 citations

Some chemical aspects of dose-response relationships in alkylation mutagenesis

1974 • 284 citations

N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

1979 • 276 citations

The properties of in templates for RNA polymerase

1973 • 264 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

1979 • 247 citations

Strategy for detection of cancer hazards to man†

1977 • 236 citations

Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea

1975 • 206 citations

Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

1975 • 193 citations

<italic>Brief Communication:</italic> Carcinogenicity of N-Methyl-N-nitrosourea: Possible Role of Excision Repair of O<sup>6</sup>-Methylguanine From DNA

1974 • 182 citations

Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography

1978 • 177 citations

Specific excision of methylation products from DNA of Escherichia coli treated with N-methyl-N′-nitro-N-nitrosoguanidine

1970 • 173 citations

Quantitation of the adaptive response to alkylating agents

1979 • 145 citations

Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate

1971 • 140 citations

Comparative Studies of the Hepatocarcinogen N,N-Dimethylnitrosamine in vivo: Reaction Sites in Rat Liver DNA and the Significance of their Relative Stabilities

1973 • 135 citations

Screening Tests in Chemical Carcinogenesis

1976 • 122 citations

Reaction of 7-bromomethylbenz[a]anthracene with nucleic acids, polynucleotides, and nucleosides

1971 • 122 citations

Induction of Liver Tumours in Rats by a Single Treatment with Nitroso Compounds given after Partial Hepatectomy

1973 • 111 citations

Formation of O6-methylguanine by alkylation of rat liver, colon, and kidney DNA following administration of 1,2-dimethylhydrazine.

1977 • 103 citations

Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.

1980 • 99 citations

Guanyl O6-arylamination and O6-arylation of DNA by the carcinogen N-hydroxy-1-naphthylamine.

1978 • 98 citations

Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine

1976 • 98 citations

Alkylation of Rat Liver DNA by Dimethylnitrosamine: Effect of Dosage on O 6 -Methylguanine Levels 2

1977 • 93 citations

The metabolic activation of the carcinogen 1'-hydroxysafrole in vivo and in vitro and the electrophilic reactivities of possible ultimate carcinogens.

1976 • 89 citations

1,2-Dimethylhydrazine-induced methylation of DNA bases in various rat organs and the effect of pretreatment with disulfiram.

1979 • 88 citations

Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts

1978 • 83 citations

The stability of methylated purines and of methylphosphotriesters in the DNA of V79 cells after treatment with N-methyl-N-nitrosourea

1979 • 80 citations

Long-term persistence of O6-methylguanine in rat brain DNA

1977 • 71 citations

Chemical Carcinogenesis Essays.

1975 • 65 citations

Alkylation of deoxyribonucleic acid in vivo in various organs of c57bl mice by the carcinogens n-methyl-n-nitrosourea, n-ethyl-n- -nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma.

1978 • 65 citations

Renal Tumours in Rats following Injection of Dimethylnitrosamine at Birth

1964 • 64 citations

The kinetics of the alkaline hydrolysis of phosphotriesters in DNA

1976 • 63 citations

The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17

1974 • 59 citations

Pretreatment with acetylaminofluorene enhances the repair of O6-methylguanine in DNA

1979 • 57 citations

Activation and inactivation of chemical carcinogens and mutagens in the mammal.

1974 • 51 citations

DNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis.

1978 • 46 citations

Excision of O6-methylguanine from DNA of various mouse tissues following a single injection of N-methyl-N-nitrosourea

1977 • 45 citations

Accumulation of O6-methylguanine in non-target-tissue deoxyribonucleic acid during chronic administration of dimethylnitrosamine

1977 • 41 citations

Two specific azodye-carcinogen-binding proteins of the rat liver

1969 • 38 citations

DNA alkylation and neuro-oncogenesis by 3,3-dimethyl-1-phenyltriazene

1978 • 38 citations

Alkylated purines in the DNA of various rat tissues after administration of 1,2-dimethylhydrazine

1977 • 38 citations

DNA phosphotriesters as indicators of cumulative carcinogen-induced damage

1978 • 36 citations

Effect of chronic N,N-diethylnitrosamine on the excision of O6-ethylguanine from rat liver DNA

1979 • 30 citations

The formation of methylated bases in DNA by dimethylnitrosamine and its relation to differences in the formation of tumours in the livers of GR and C3Hf mice

1974 • 29 citations

Current concepts on mechanisms of chemical carcinogenesis.

1978 • 28 citations

Studies on lung tumours. IV. correlation between [3H]thymidine labelling of lung and liver cells and tumour formation in GRS/A and C3Hf/A male mice following administration of dimethylnitrosamine

1979 • 28 citations

The accumulation of O6-methylguanine in the liver and kidney DNA of rats treated with dimethylnitrosamine for a short or a long period

1977 • 27 citations

Partial hepatectomy and toxicity of dimethyl-nitrosamine and carbon tetrachloride, in relation to the carcinogenic action of dimethylnitrosamine

1975 • 24 citations

Selective accumulation of O6-methylguanine in DNA of rat bladder epithelium after intravesical administration of N-methyl-N-nitrosourea

1977 • 23 citations

O6-methylguanine accumulates in DNA of mammary glands after administration of N-methyl-N-nitrosourea to rats

1979 • 23 citations

The effects of a single dose of dimethylnitrosamine in the Chinese hamster and the persistence of DNA alkylation products in selected tissues

1980 • 22 citations

Reactions of the carcinogen N-acetoxy-4-acetamidostilbene with nucleosides

1979 • 19 citations

In vivo alkylation of foetal, maternal and normal rat tissue nucleic acids by 3-methyl-1-phenyltriazene

1979 • 17 citations

Induction of presumptive preneoplastic lesions in rat liver by a single dose of 1,2-dimethylhydrazine

1979 • 16 citations

Methylation of DNAase-digestible DNA and of RNA in chromatin from rats treated with dimethylnitrosamine

1979 • 16 citations

Essays in biochemistry. Vol 26

1992 • 9 citations

Effect of hypophysectomy on persistence of methylated purines in rat liver deoxyribonucleic acid after administration of dimethylnitrosamine

1978 • 9 citations