Mucosal Immunity: Implications for Vaccine Development

The route of re-circulation of lymphocytes in the rat

1964 • 1,449 citations

A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells

1983 • 1,054 citations

The common mucosal immune system and current strategies for induction of immune responses in external secretions

1987 • 810 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR I<scp>G</scp>A-PRODUCING IMMUNOCYTES IN THE RABBIT

1971 • 756 citations

Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues.

1979 • 732 citations

A tissue-specific endothelial cell molecule involved in lymphocyte homing

1988 • 725 citations

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells

1983 • 561 citations

Actions of cholera toxin and the prevention and treatment of cholera

1981 • 532 citations

Tissue Receptor for Cholera Exotoxin: Postulated Structure from Studies with G _M1 Ganglioside and Related Glycolipids

1973 • 461 citations

Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens.

1986 • 428 citations

Evidence for a Common Mucosal Immunologic System

1979 • 410 citations

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

1989 • 394 citations

FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

1986 • 353 citations

Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. I. T cells derived from Peyer's patches that switch sIgM B Cells to sIgA B cells in vitro

1983 • 287 citations

IgA subclasses in various secretions and in serum.

1982 • 285 citations

The Regulation of Lymphocyte Traffic

1986 • 285 citations

T-cell regulation of murine IgA synthesis.

1979 • 279 citations

Regulation of IgA synthesis and immune response by T cells and interleukins

1989 • 278 citations

Overview of the Mucosal Immune System

1989 • 272 citations

IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans.

1987 • 264 citations

Organ and Isotype Distribution of Plasma Cells Producing Specific Antibody after Oral Immunization: Evidence for A Generalized Secretory Immune System

1979 • 254 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Mucosal Antitoxic and Antibacterial Immunity after Cholera Disease and after Immunization with a Combined B Subunit-Whole Cell Vaccine

1984 • 235 citations

Interferon-gamma enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins.

1987 • 235 citations

Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins.

1989 • 235 citations

Distribution of IgA1-, IgA2-, and J chain-containing cells in human tissues.

1984 • 232 citations

Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memory.

1991 • 226 citations

Topics in Pharmaceutical Sciences

1983 • 226 citations

Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

1991 • 192 citations

DETECTION OF FORMIMINOGLUTAMIC ACID IN URINE WITHOUT HISTIDINE LOADING

1962 • 191 citations

Combined oral/nasal immunization protects mice from Sendai virus infection.

1987 • 177 citations

Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease

1986 • 171 citations

A novel two colour ELISPOT assay

1988 • 166 citations

Protective efficacy in humans of killed whole-vibrio oral cholera vaccine with and without the B subunit of cholera toxin

1987 • 164 citations

Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.

1989 • 161 citations

Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans

1991 • 142 citations

Oral administration of cholera toxin-Sendai virus conjugate potentiates gut and respiratory immunity against Sendai virus.

1988 • 133 citations

Specific Immunoglobulin-Secreting Human Blood Cells After Peroral Vaccination Against Salmonella typhi

1986 • 124 citations

IDENTIFICATION OF AN INTESTINAL IMMUNE RESPONSE USING PERIPHERAL BLOOD LYMPHOCYTES

1988 • 122 citations

Determinants of the localization, magnitude, and duration of a specific mucosal IgA plasma cell response in enterically immunized rats.

1982 • 117 citations

Development of improved cholera vaccine based on subunit toxoid

1977 • 109 citations

ORAL IMMUNISATION WITH KILLED HAEMOPHILUS INFLUENZAE FOR PROTECTION AGAINST ACUTE BRONCHITIS IN CHRONIC OBSTRUCTIVE LUNG DISEASE

1985 • 107 citations

Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo.

1989 • 100 citations

Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogens.

1980 • 98 citations

Cholera Toxin as a Mucosal Adjuvant

1996 • 91 citations

Protection against Cholera Toxin after Oral Immunization is Thymus‐Dependent and Associated with Intestinal Production of Neutralizing IgA Antitoxin

1987 • 89 citations

Boosting of Secretory IgA Antibody Responses in Man by Parenteral Cholera Vaccination

1977 • 85 citations

INTESTINAL ANTIBODY RESPONSES AFTER IMMUNISATION WITH CHOLERA B SUBUNIT

1982 • 81 citations

Development of an Oral Vaccine Against Enterotoxigenic Escherichia coli Diarrhea

1991 • 80 citations

Gamma‐Interferon‐Mediated Down‐Regulation of Electrolyte Secretion by Intestinal Epithelial Cells: A Local Immune Mechanism?

1989 • 69 citations

Local and Systemic Antibody Responses to Naturally Acquired Enterotoxigenic Escherichia coli Diarrhea in an Endemic Area

1986 • 69 citations

Cholera antibody production in vitro by peripheral blood lymphocytes following oral immunization of humans and mice.

1985 • 62 citations

Detection of Coproantibody and its Formation after Parenteral and Oral Immunization of Human Volunteers*

1962 • 59 citations

Bacterial infections of respiratory and gastrointestinal mucosae

1988 • 59 citations

Recombinant cholera toxin B subunit and gene fusion proteins for oral vaccination

1990 • 50 citations

Antitoxic Cholera Immunity in Mice: Influence of Antigen Deposition on Antitoxin-Containing Cells and Protective Immunity in Different Parts of the Intestine

1980 • 42 citations

THE MUCOSAL IMMUNOLOGICAL NETWORK: COMPARTMENTALIZATION OF LYMPHOCYTES, NATURAL KILLER CELLS, AND MAST CELLS*

1983 • 42 citations

Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin

1989 • 35 citations

New Strategies for Oral Immunization

1989 • 28 citations

Immunoprophylaxis of Chlamydia trachomatis lymphogranuloma venereum pneumonitis in mice by oral immunization

1989 • 19 citations

Enterotoxigenic Escherichia coli diarrhea in an endemic area prepares the intestine for an anamnestic immunoglobulin A antitoxin response to oral cholera B subunit vaccination

1988 • 13 citations

Thermolysin treatment; an improved dispersion technique for isolating functional lymphoid cells from intestinal tissues

1990 • 7 citations

Lymphoid cell populations dynamics and the mucosal immune response in humans

1990 • 6 citations