Evidence for a Direct Interaction between Insulin Receptor Substrate-1 and Shc

Experiments in molecular genetics

1972 • 28,260 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein

1996 • 480 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

Cellular interactions in development : a practical approach

1993 • 373 citations

Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

1995 • 368 citations

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1995 • 361 citations

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

1994 • 334 citations

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

1996 • 314 citations

Not all Shc's roads lead to Ras

1996 • 239 citations

Insulin Receptor Substrate-2 Binds to the Insulin Receptor through Its Phosphotyrosine-binding Domain and through a Newly Identified Domain Comprising Amino Acids 591–786

1996 • 194 citations

The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif

1995 • 175 citations

SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides.

1994 • 134 citations

Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 133 citations

A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.

1996 • 130 citations

The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation

1996 • 127 citations

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.

1994 • 126 citations

Evidence for a Differential Interaction of SHC and the Insulin Receptor Substrate-1 (IRS-1) with the Insulin-like Growth Factor-I (IGF-I) Receptor in the Yeast Two-hybrid System

1995 • 117 citations

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

1994 • 116 citations

Interaction of Shc with Adaptor Protein Adaptins

1996 • 114 citations

Involvement of Src‐homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin‐like‐growth‐factor‐I‐receptor

1994 • 112 citations

Use of the two hybrid system to detect the association of the protein-tyrosine-phosphatase, SHPTP2, with another SH2-containing protein, Grb7.

1996 • 98 citations

YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation Sites

1996 • 91 citations

Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

1994 • 88 citations

Phosphotyrosine-independent Binding of SHC to the NPLH Sequence of Murine Protein-tyrosine Phosphatase-PEST

1996 • 78 citations

Shc Proteins Are Localized on Endoplasmic Reticulum Membranes and Are Redistributed after Tyrosine Kinase Receptor Activation

1996 • 74 citations

Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction

1995 • 73 citations

Insulin and Epidermal Growth Factor Receptors Regulate Distinct Pools of Grb2-SOS in the Control of Ras Activation

1996 • 68 citations

Affinity, Specificity, and Kinetics of the Interaction of the SHC Phosphotyrosine Binding Domain with Asparagine-X-X-Phosphotyrosine Motifs of Growth Factor Receptors

1996 • 68 citations

In Vivo Association of v-Abl with Shc Mediated by a Non-phosphotyrosine-dependent SH2 Interaction

1996 • 65 citations

Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave

1996 • 64 citations

Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase.

1994 • 62 citations

New frontiers in insulin receptor substrate signaling

1995 • 60 citations