Antipsychotic Drugs for First-Episode Schizophrenia

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

2005 • 5,799 citations

Neurocognitive Deficits and Functional Outcome in Schizophrenia: Are We Measuring the "Right Stuff"?

2000 • 2,955 citations

A review of MRI findings in schizophrenia

2001 • 2,310 citations

Meta-Analysis of Regional Brain Volumes in Schizophrenia

2000 • 1,657 citations

Association Between Duration of Untreated Psychosis and Outcome in Cohorts of First-Episode Patients

2005 • 1,480 citations

Discovering the Neural Basis of Human Social Anxiety: A Diagnostic and Therapeutic Imperative

2004 • 1,429 citations

Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison

2003 • 1,308 citations

Deficit and nondeficit forms of schizophrenia: the concept

1988 • 1,307 citations

Relationship Between Duration of Untreated Psychosis and Outcome in First-Episode Schizophrenia: A Critical Review and Meta-Analysis

2005 • 1,283 citations

The NIMH-MATRICS Consensus Statement on Negative Symptoms

2006 • 1,180 citations

Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial

2008 • 1,049 citations

Neurocognitive Effects of Antipsychotic Medications in Patients With Chronic Schizophrenia in the CATIE Trial

2007 • 1,036 citations

Neuropsychology of First-Episode Schizophrenia: Initial Characterization and Clinical Correlates

2000 • 922 citations

Predictive Values of Neurocognition and Negative Symptoms on Functional Outcome in Schizophrenia: A Longitudinal First-Episode Study With 7-Year Follow-Up

2005 • 898 citations

Antipsychotic Drug Effects on Brain Morphology in First-Episode Psychosis

2005 • 780 citations

Neuroleptics and the Natural Course of Schizophrenia

1991 • 777 citations

Hippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging

1998 • 753 citations

The Effects of Atypical Antipsychotic Drugs on Neurocognitive Impairment in Schizophrenia: A Review and Meta-analysis

1999 • 698 citations

Lower Risk for Tardive Dyskinesia Associated With Second-Generation Antipsychotics: A Systematic Review of 1-Year Studies

2004 • 691 citations

The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Project: Schizophrenia Trial Design and Protocol Development

2003 • 634 citations

Studies of Cognitive Change in Patients With Schizophrenia Following Novel Antipsychotic Treatment

2001 • 622 citations

Symptomatic and Functional Recovery From a First Episode of Schizophrenia or Schizoaffective Disorder

2004 • 588 citations

A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia

2005 • 586 citations

Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs

1994 • 572 citations

Longitudinal study of brain morphology in first episode schizophrenia

2001 • 558 citations

A Selective Review of Recent North American Long-term Followup Studies of Schizophrenia

1988 • 556 citations

A Follow-up Magnetic Resonance Imaging Study of Schizophrenia

1998 • 542 citations

Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia

1997 • 517 citations

Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11

1994 • 486 citations

Is schizophrenia a neurodegenerative disorder? a clinical and neurobiological perspective

1999 • 476 citations

Why Olanzapine Beats Risperidone, Risperidone Beats Quetiapine, and Quetiapine Beats Olanzapine: An Exploratory Analysis of Head-to-Head Comparison Studies of Second-Generation Antipsychotics

2006 • 453 citations

Subcortical MRI Volumes in Neuroleptic-Naive and Treated Patients With Schizophrenia

1998 • 441 citations

Persistent Negative Symptoms in Schizophrenia: An Overview

2006 • 415 citations

Antipsychotic medications: metabolic and cardiovascular risk.

2007 • 412 citations

Comparative Efficacy and Safety of Atypical and Conventional Antipsychotic Drugs in First-Episode Psychosis: A Randomized, Double-Blind Trial of Olanzapine Versus Haloperidol

2003 • 401 citations

Brain Volume Changes in First-Episode Schizophrenia

2002 • 397 citations

Optimal Dose of Neuroleptic in Acute Schizophrenia

1991 • 384 citations

Cognitive Deficits in Schizophrenia

1993 • 371 citations

Progressive Decrease of Left Superior Temporal Gyrus Gray Matter Volume in Patients With First-Episode Schizophrenia

2002 • 368 citations

Causes and consequences of duration of untreated psychosis in schizophrenia

2000 • 353 citations

Efficacy and Tolerability of Olanzapine, Quetiapine, and Risperidone in the Treatment of Early Psychosis: A Randomized, Double-Blind 52-Week Comparison

2007 • 352 citations

Atypical and Conventional Antipsychotic Drugs in Treatment-Naive First-Episode Schizophrenia: A 52-Week Randomized Trial of Clozapine Vs Chlorpromazine

2003 • 344 citations

Risperidone and Haloperidol in First-Episode Psychosis: A Long-Term Randomized Trial

2005 • 344 citations

Longitudinal Assessment of Premorbid Cognitive Functioning in Patients With Schizophrenia Through Examination of Standardized Scholastic Test Performance

2002 • 335 citations

Neuropsychological Risk Indicators for Schizophrenia: A Review of Family Studies

1994 • 303 citations

Progressive brain structural changes mapped as psychosis develops in ‘at risk’ individuals

2009 • 295 citations

The Texas Medication Algorithm Project Antipsychotic Algorithm for Schizophrenia

2007 • 295 citations

Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorder

2002 • 285 citations

Association of Anticholinergic Load With Impairment of Complex Attention and Memory in Schizophrenia

2004 • 274 citations

Progressive Brain Volume Loss in Schizophrenia Over the Course of the Illness: Evidence of Maturational Abnormalities in Early Adulthood

2007 • 270 citations

Effects of Olanzapine, Quetiapine, and Risperidone on Neurocognitive Function in Early Psychosis: A Randomized, Double-Blind 52-Week Comparison

2007 • 264 citations

Structural abnormalities in deficit and nondeficit schizophrenia

1993 • 260 citations

Change in Basal Ganglia Volume Over 2 Years in Patients With Schizophrenia: Typical Versus Atypical Neuroleptics

1999 • 259 citations

The Texas Medication Algorithm Project Antipsychotic Algorithm for Schizophrenia

2004 • 245 citations

Pharmacological treatment of primary negative symptoms in schizophrenia: A systematic review

2006 • 213 citations

Predictors of Treatment Discontinuation and Medication Nonadherence in Patients Recovering From a First Episode of Schizophrenia, Schizophreniform Disorder, or Schizoaffective Disorder

2008 • 208 citations

Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol

2005 • 199 citations

Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode

2003 • 188 citations

Risperidone in the Treatment of First-Episode Psychotic Patients: A Double-Blind Multicenter Study

1999 • 185 citations

The McLean–Harvard first-episode project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis

2000 • 176 citations

Caudate, putamen, and globus pallidus volume in schizophrenia: A quantitative MRI study

1995 • 173 citations

Early intervention in psychotic disorders: detection and treatment of the first episode and the critical early stages

2007 • 169 citations

Treatment of Cognitive Impairment in Early Psychosis: A Comparison of Risperidone and Haloperidol in a Large Long-Term Trial

2005 • 162 citations

Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode

2006 • 158 citations

Modeling the Early Course of Schizophrenia

2003 • 155 citations

Adverse Effects of Risperidone on Spatial Working Memory in First-Episode Schizophrenia

2006 • 150 citations

Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment

1996 • 141 citations

Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic

2002 • 138 citations

Incidence and Correlates of Tardive Dyskinesia in First Episode of Schizophrenia

1996 • 135 citations

Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

2006 • 134 citations

Atypical Depression: A Valid Subtype?

2007 • 134 citations

The Effect of Clozapine on Caudate Nucleus Volume in Schizophrenic Patients Previously Treated with Typical Antipsychotics

2001 • 124 citations

Olanzapine and haloperidol in first episode psychosis: Two-year data

2006 • 120 citations

Symptoms Versus Neurocognitive Test Performance as Predictors of Psychosocial Status in Schizophrenia: A 1- and 4-Year Prospective Study

2005 • 120 citations

Long-Term Neurocognitive Effects of Olanzapine or Low-Dose Haloperidol in First-Episode Psychosis

2005 • 118 citations

Enduring negative symptoms in first-episode psychosis: comparison of six methods using follow-up data

1999 • 108 citations

Extrapyramidal Signs and Clinical Symptoms in First-Episode Schizophrenia

1997 • 106 citations

Striatal Volume Changes in the Rat Following Long-term Administration of Typical and Atypical Antipsychotic Drugs

2002 • 101 citations

Striatal enlargement in rats chronically treated with neuroleptic

1998 • 100 citations

Randomized Comparison of Olanzapine Versus Risperidone for the Treatment of First-Episode Schizophrenia: 4-Month Outcomes

2006 • 98 citations

The deficit state in first-episode schizophrenia

1994 • 98 citations

Cognitive functioning in first-episode schizophrenia.

2002 • 94 citations

Incidence of Tardive Dyskinesia in First-Episode Psychosis Patients Treated With Low-Dose Haloperidol

2003 • 74 citations

Risperidone, 2 mg/day vs. 4 mg/day, in First-Episode, Acutely Psychotic Patients

2002 • 64 citations

Should Clozapine Be a First-line Treatment for Schizophrenia? The Rationale for a Double-Blind Clinical Trial in First-Episode Patients

1995 • 41 citations

Atypical Depression: A Valid Subtype?

2007 • 35 citations

Preventing Clinical Deterioration in the Course of Schizophrenia: The Potential for Neuroprotection

2006 • 35 citations

Effects of chronic treatment with typical and atypical antipsychotic drugs on the rat striatum

1999 • 28 citations

Effect of chronic olanzapine treatment on striatal synaptic organization

2000 • 23 citations

Are all antipsychotics equal? – Authors' reply

2008 • 3 citations