Should Clozapine Be a First-line Treatment for Schizophrenia? The Rationale for a Double-Blind Clinical Trial in First-Episode Patients

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

1990 • 2,630 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

Neuroleptics and the Natural Course of Schizophrenia

1991 • 777 citations

Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

1989 • 600 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine

1993 • 403 citations

Clinical and Biologic Response to Clozapine in Patients With Schizophrenia

1992 • 356 citations

D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics

1989 • 322 citations

Neuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristics

1980 • 300 citations

Dimensions of Outcome with Clozapine

1992 • 256 citations

Mechanisms of action of atypical antipsychotic drugs

1991 • 254 citations

Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro

1984 • 224 citations

Plasma Homovanillic Acid as a Predictor of Response to Neuroleptics

1988 • 205 citations

CLOZAPINE AND HALOPERIDOL IN A SINGLE‐BLIND CROSS‐OVER TRIAL: THERAPEUTIC AND BIOCHEMICAL ASPECTS IN THE TREATMENT OF SCHIZOPHRENIA

1974 • 198 citations

Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons

1985 • 196 citations

The Natural Course of Schizophrenia: A Review of First-admission Studies

1992 • 193 citations

Clinical Management of Clozapine Patients in Relation to Efficacy and Side-Effects

1992 • 181 citations

Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites

1990 • 173 citations

A Comparison of Plasma Homovanillic Acid Concentrations in Schizophrenic Patients and Normal Controls

1988 • 153 citations

Subtype Progression and Pathophysiologic Deterioration in Early Schizophrenia

1993 • 152 citations

Plasma catecholamine metabolites and early response to haloperidol.

1984 • 146 citations

Clozapine, Chlorpromazine, and Placebo in Newly Hospitalized, Acutely Schizophrenic Patients

1979 • 146 citations

Clinical Services Research

1992 • 136 citations

Dopamine and the pharmacology of schizophrenia: The state of the evidence

1974 • 99 citations

Who Should Receive Clozapine?

1988 • 91 citations

Perspectives on a Time-dependent Model of Neuroleptic Action

1988 • 84 citations

Clozapine: Plasma levels and prolactin response

1981 • 83 citations

Clozapine response and plasma catecholamines and their metabolites

1993 • 78 citations

Haloperidol given chronically decreases basal dopamine in the prefrontal cortex more than the striatum or nucleus accumbens as simultaneously measured by microdialysis

1989 • 74 citations

Clozapine versus chlorpromazine for the treatment of schizophrenia: preliminary results from a double-blind study.

1979 • 72 citations

Clozapine (Leponex) compared with chlorpromazine: a double-blind evaluation of pharmacological and clinical properties.

1974 • 71 citations

Plasma catecholamine metabolites in Schizophrenics: Evidence for the two-subtype concept

1990 • 70 citations

Differential effects of repeated treatment with haloperidol and clozapine on dopamine release and metabolism in the striatum and the nucleus accumbens.

1991 • 69 citations

Low serum prolactin and early relapse following neuroleptic withdrawal

1981 • 65 citations

Long-term neuroleptic treatment of chronic schizophrenic patients: Clinical and biochemical effects of withdrawal

1981 • 61 citations

The effects of clozapine and fluperlapine on the in vivo release and metabolism of dopamine in the striatum and in the prefrontal cortex of freely moving rats.

1989 • 59 citations

Enhanced prolactin inhibition following chronic treatment with haloperidol and morphine

1977 • 58 citations

Tolerance to the prolactin-elevating effect of neuroleptics

1981 • 51 citations

Plasma Norepinephrine and Dopamine-β-Hydroxylase Activity in Schizophrenia

1982 • 48 citations

In VitroSupersensitivity of the Anterior Pituitary to Dopamine Inhibition of Prolactin Secretion*

1978 • 43 citations

The Concept of Supersensitivity Psychosis

1992 • 40 citations

Haloperidol response and plasma catecholamines and their metabolites

1993 • 36 citations

Clozapine in the Treatment of Newly Admitted Schizophrenic Patients A Pilot Study

1976 • 36 citations

Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat

1987 • 36 citations

Clozapine in the treatment of schizophrenic patients: an international multicenter trial.

1987 • 33 citations

Enhancement of dopamine metabolism in rat brain frontal cortex: a common effect of chronically administered antipsychotic drugs

1988 • 28 citations

Neuroleptic discontinuation in the very stable schizophrenic patient: Relapse rates and serum neuroleptic levels

1992 • 28 citations

Prolactin and Neuroleptic Drugs

1988 • 27 citations

Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements during maintenance haloperidol treatment in male patients with schizophrenia

1992 • 26 citations

Induction of dopaminergic mesolimbic receptor supersensitivity by haloperidol

1978 • 26 citations

Possible associations among plasma prolactin levels, tardive dyskinesia, and paranoia in treated male schizophrenics

1986 • 25 citations

Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs

1990 • 25 citations

Plasma HVA in psychiatric patients: longitudinal studies.

1990 • 24 citations

Effects of acute and chronic clozapine on dopaminergic function in medial prefrontal cortex of awake, freely moving rats

1992 • 23 citations

Serum neuroleptic levels, prolactin levels, and relapse: a two-year study of schizophrenic outpatients.

1987 • 23 citations

Prolactin shifts after neuroleptic withdrawal

1990 • 22 citations

Time course and clinical predictors of treatment response in schizophrenia

1991 • 21 citations

Clozapine induced increase of human plasma norepinephrine

1979 • 21 citations

Neuroleptic-induced supersensitivity psychosis: retrospective study of schizophrenic inpatients.

1988 • 21 citations

Drug Withdrawal in Chronic Schizophrenic Patients

1981 • 19 citations

Timing of Acute Clinical Response to Fluphenazine

1992 • 17 citations

Clozapine: Benefits and Risks

1990 • 15 citations

Evidence for sensitization in the early stage of schizophrenia

1996 • 8 citations

Patterns of Neuroleptic Usage in Continuously Hospitalized Chronic Schizophrenic Patients: Evidence for Development of Drug Tolerance

1990 • 8 citations

Basal and stimulated levels of prolactin, TSH, and LH in serum of chronic schizophrenic patients long-term treated with neuroleptics: relations to psychopathology.

1980 • 8 citations

Deleted Work

1955 • 0 citations