Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1

A new force field for molecular mechanical simulation of nucleic acids and proteins

1984 • 4,553 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

THIOREDOXIN

1985 • 1,885 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

1988 • 638 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.

1992 • 463 citations

Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds.

1988 • 445 citations

An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

1992 • 353 citations

Inhibition of human immunodeficiency virus infection by agents that interfere with thiol-disulfide interchange upon virus-receptor interaction.

1994 • 279 citations

HIV-induced cysteine deficiency and T-cell dysfunction — a rationale for treatment with N-acetylcysteine

1992 • 254 citations

The Chemistry of Organic Arsenic, Antimony and Bismuth Compounds

1994 • 252 citations

Elevation of plasma thioredoxin levels in HIV-infected individuals

1996 • 209 citations

The crystallographically determined structures of atypical strained disulfides engineered into subtilisin.

1986 • 182 citations

Redox Control of Exofacial Protein Thiols/Disulfides by Protein Disulfide Isomerase

1999 • 178 citations

Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma.

2000 • 176 citations

N-Acetylcysteine: A New Approach to Anti-HIV Therapy

1992 • 157 citations

Chronic elevation of plasma thioredoxin: Inhibition of chemotaxis and curtailment of life expectancy in AIDS

2001 • 146 citations

Crystal Structure of Domains 3 and 4 of Rat CD4: Relation to the NH₂-Terminal Domains

1993 • 142 citations

A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells

1992 • 132 citations

Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion.

1992 • 128 citations

Determinants of CD4 Independence for a Human Immunodeficiency Virus Type 1 Variant Map outside Regions Required for Coreceptor Specificity

1999 • 122 citations

Presence of closely spaced protein thiols on the surface of mammalian cells

2000 • 119 citations

Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals.

1994 • 112 citations

Structural Diversity in Domains of the Immunoglobulin Superfamily

1989 • 102 citations

Current Evidence and Future Directions for Targeting HIV Entry

2000 • 95 citations

HIV-1 Entry Inhibitors in the Side Pocket

1999 • 85 citations

Interactions between MHC molecules and co-receptors of the TCR

2002 • 84 citations

Human Plasma Lecithin-Cholesterol Acyltransferase

1989 • 81 citations

Human plasma lecithin-cholesterol acyltransferase. The vicinal nature of cysteine 31 and cysteine 184 in the catalytic site.

1988 • 68 citations

Cyclic cystine peptides. Antiparallel .beta.-sheet conformation for the 20-membered ring in Boc-Cys-Val-Aib-Ala-Leu-Cys-NHMe

1988 • 58 citations

Junctional plasma membrane domains isolated from aggregating Dictyostelium discoideum amebae.

1986 • 54 citations

Direct evidence for native CD4 oligomers in lymphoid and monocytoid cells

1999 • 52 citations

Identification of a thioredoxin — related protein associated with plasma membranes

1991 • 50 citations

Synthesis of Human Immunodeficiency Virus DNA In a Cell-to-Cell Transmission Model

1992 • 49 citations

Specific Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Integration in Cell Culture: Putative Inhibitors of HIV-1 Integrase

2001 • 43 citations

Characterization of a soluble form of human CD4

1990 • 40 citations

Cystamine potently suppresses in vitro HIV replication in acutely and chronically infected human cells.

1994 • 37 citations

Detection of Membrane Associated Thioredoxin on Human Cell Lines

1997 • 33 citations

Normal-mode analysis suggests important flexibility between the two N-terminal domains of CD4 and supports the hypothesis of a conformational change in CD4 upon HIV binding

1996 • 29 citations

Site-directed mutagenesis of human thioredoxin. Identification of cysteine 74 as critical to its function in the “early pregnancy factor” system.

1993 • 29 citations

Selective inhibition of replication of the AIDS-associated virus HTLV-III/LAV by synthetic D-penicillamine.

1986 • 26 citations

Cystamine Inhibits HIV Type 1 Replication in Cells of Monocyte/Macrophage and T Cell Lineages

1995 • 24 citations

In Vitro Inhibition of the Replication of Human Immunodeficiency Virus Type 1 by -Mercaptoethylamine (Cysteamine)

1996 • 23 citations

The alpha-chain of murine CD8 lacks an invariant Ig-like disulfide bond but contains a unique intrachain loop instead.

1989 • 22 citations

A human recombinant Fab identifies a human immunodeficiency virus type 1-induced conformational change in cell surface-expressed CD4

1995 • 22 citations

Cystine peptides Antiparallel β-sheet conformation of the cyclic biscystine pep tide [Boc-Cys-Ala-Cys-NHCH3]2

2009 • 19 citations

Treatment of HTLV-III/LAV-infected patients with D-penicillamine.

1986 • 17 citations

Structural Chemistry of Organic Compounds Containing Arsenic, Antimony and Bismuth

2004 • 10 citations